Baicalein
It has a role as an antioxidant, a hormone antagonist, a prostaglandin antagonist, an EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor, an EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor, a radical scavenger, an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor, an anti-inflammatory agent, a plant metabolite, a ferroptosis inhibitor, an anticoronaviral agent, an EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor, an angiogenesis inhibitor, an antineoplastic agent, an EC 4.1.1.17 (ornithine decarboxylase) inhibitor, an antibacterial agent, an antifungal agent, an apoptosis inducer. Natural product found in Scutellaria baicalensis
General
Chemical_Nomenclature : 5,6,7-trihydroxy-2-phenylchromen-4-one
Canonical SMILES : C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(C(=C3O)O)O
InChI : InChI=1S\/C15H10O5\/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12\/h1-7,17-19H
InChIKey : FXNFHKRTJBSTCS-UHFFFAOYSA-N
Other name(s) : 5,6,7-Trihydroxyflavone, Noroxylin, CHEBI:2979, CHEMBL8260
MW : 270.24
Formula : C15H10O5
CAS_number : 491-67-8
PubChem : 5281605
UniChem : FXNFHKRTJBSTCS-UHFFFAOYSA-N
Target
Families : Baicalein ligand of proteins in family
Carb_B_Chordata
References (7)
| Title : Baicalein 5,6-Dimethyl Ether Prevents Memory Deficits in the Scopolamine Zebrafish Model by Regulating Cholinergic and Antioxidant Systems - Brinza_2021_Plants.(Basel)_10_ |
| Author(s) : Brinza I , Ayoub IM , Eldahshan OA , Hritcu L |
| Ref : Plants (Basel) , 10 : , 2021 |
| PubMedID: 34207381 |
| Title : Baicalein improves behavioral dysfunction induced by Alzheimer's disease in rats - Zhou_2016_Neuropsychiatr.Dis.Treat_12_3145 |
| Author(s) : Zhou L , Tan S , Shan YL , Wang YG , Cai W , Huang XH , Liao XY , Li HY , Zhang L , Zhang BJ , Lu ZQ |
| Ref : Neuropsychiatr Dis Treat , 12 :3145 , 2016 |
| PubMedID: 28003750 |
| Title : Synergistic Action of Flavonoids, Baicalein, and Daidzein in Estrogenic and Neuroprotective Effects: A Development of Potential Health Products and Therapeutic Drugs against Alzheimer's Disease - Choi_2013_Evid.Based.Complement.Alternat.Med_2013_635694 |
| Author(s) : Choi RC , Zhu JT , Yung AW , Lee PS , Xu SL , Guo AJ , Zhu KY , Dong TTX , Tsim KWK |
| Ref : Evid Based Complement Alternat Med , 2013 :635694 , 2013 |
| PubMedID: 24058373 |