Benzothiazole-phenyl-thioacetamide-Cpd30
IC50 MAO-B 0.015 +/- 0.007 microM; AChE 0.114 +/- 0.003 microM; BChE 4.125 +/- 0.143 microM
General
Type : Monoamine-oxidase-inhibitor, Multitarget, Naphthalen, Benzothiazol, Sulfur Compound
Chemical_Nomenclature : N-(3,4-dimethylphenyl)-2-[[6-[(2-hydroxynaphthalen-1-yl)methylideneamino]-1,3-benzothiazol-2-yl]sulfanyl]acetamide
Canonical SMILES : C1=CC=CC2=C1C=CC(=C2C=NC3=CC=C4C(=C3)SC(=N4)SCC(=O)NC5=CC=C(C(=C5)C)C)O
InChI : InChI=1S\/C28H23N3O2S2\/c1-17-7-9-21(13-18(17)2)30-27(33)16-34-28-31-24-11-10-20(14-26(24)35-28)29-15-23-22-6-4-3-5-19(22)8-12-25(23)32\/h3-15,32H,16H2,1-2H3,(H,30,33)
InChIKey : BQMRKUOTSPIZLY-UHFFFAOYSA-N
Other name(s) :
Target
Families : Benzothiazole-phenyl-thioacetamide-Cpd30 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Design, synthesis and evaluation of benzothiazole-derived phenyl thioacetamides as dual inhibitors of monoamine oxidases and cholinesterases - Kumar_2024_Mol.Divers__ |
| Author(s) : Kumar S , Mitra R , Ayyannan SR |
| Ref : Mol Divers , : , 2024 |
| Abstract : |
| PubMedSearch : Kumar_2024_Mol.Divers__ |
| PubMedID: 39520616 |