Biphenyl-oxo-triazine-piperazine-cpd6g
6g inhibits AChE, IC50; 0.2 +/- 0.01 microM) 6g exhibited significant displacement of propidium iodide from the peripheral anionic site (PAS) of AChE (22.22 +/- 1.11%) showed good CNS permeability in PAMPA-BBB assaysignificant improvement in cognitive dysfunctions against scopolamine-induced amnesia mouse models
General
Type : Piperazine, Multitarget, Triazine
Chemical_Nomenclature : 5,6-diphenyl-3-oxo-2-(3-(4-benzylpiperazin-1-yl)propyl)-1,2,4-triazine
Canonical SMILES : C1=CC=C(C=C1)C2=NN(C(N=C2C3=CC=CC=C3)=O)CCCN4CCN(CC4)CC5=CC=CC=C5
InChI : InChI=1S\/C29H31N5O\/c35-29-30-27(25-13-6-2-7-14-25)28(26-15-8-3-9-16-26)31-34(29)18-10-17-32-19-21-33(22-20-32)23-24-11-4-1-5-12-24\/h1-9,11-16H,10,17-23H2
InChIKey : ITLGUIUYNVYGJX-UHFFFAOYSA-N
Other name(s) : Compound 6g
Target
Families : Biphenyl-oxo-triazine-piperazine-cpd6g ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Biphenyl-3-oxo-1,2,4-triazine linked piperazine derivatives as potential cholinesterase inhibitors with anti-oxidant property to improve the learning and memory - Tripathi_2018_Bioorg.Chem_85_82 |
| Author(s) : Tripathi PN , Srivastava P , Sharma P , Tripathi MK , Seth A , Tripathi A , Rai SN , Singh SP , Shrivastava SK |
| Ref : Bioorg Chem , 85 :82 , 2018 |
| Abstract : |
| PubMedSearch : Tripathi_2018_Bioorg.Chem_85_82 |
| PubMedID: 30605887 |