CGA-134-735
Natural organophosphate inhibitor of Acetylcholinesterase isolated from cultures of Streptomyces antibioticus strain DSM 1951. Compound very close to Cyclophostin described by Kurokawa 1993 J.Antibiot.(Tokyo) 46 1315 and of Cyclopostins inhibitors of HSL. IC50 for AChE of 100 nM
General
Type : Organophosphate, Cyclic OP, Natural
Chemical_Nomenclature : propyl substituted furo-dioxaphosphepin
Canonical SMILES : [P@@]1(OC[C@@H]2C(=C(O1)C(C)C)COC2)(OC)=O
InChI : InChI=1S\/C10H17O5P\/c1-7(2)10-9-6-13-4-8(9)5-14-16(11,12-3)15-10\/h7-8H,4-6H2,1-3H3\/t8-,16-\/m1\/s1
InChIKey : HIMGSUFZVJAGDK-VPTHRUTESA-N
Other name(s) :
Target
Families : CGA-134-735 ligand of proteins in family
ACHE
References (1)
| Title : Insecticidal organophosphates: Nature made them first - Neumann_1987_Experientia_43_1235 |
| Author(s) : Neumann R , Peter HH |
| Ref : Experientia , 43 :1235-1237 , 1987 |
| Abstract : |
| PubMedSearch : Neumann_1987_Experientia_43_1235 |
| PubMedID: |