CHEMBL513063
IC50 of 8c was 0.51 microM
General
Type : Sulfur Compound, Thiazole, Pyrrolidine
Chemical_Nomenclature : N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-3-pyrrolidin-1-ylpropanamide
Canonical SMILES : COC1=CC=C(C=C1)C2=CSC(=N2)NC(=O)CCN3CCCC3
InChI : InChI=1S\/C17H21N3O2S\/c1-22-14-6-4-13(5-7-14)15-12-23-17(18-15)19-16(21)8-11-20-9-2-3-10-20\/h4-7,12H,2-3,8-11H2,1H3,(H,18,19,21)
InChIKey : YRVHWRSOZONPGM-UHFFFAOYSA-N
Other name(s) : BDBM50544937 || M-1 || 8c
MW : 331.4
Formula : C17H21N3O2S
CAS_number :
PubChem : 44565722
UniChem : YRVHWRSOZONPGM-UHFFFAOYSA-N
Target
Families : CHEMBL513063 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (2)
| Title : Synthesis, in vitro assays, molecular docking, theoretical ADMET prediction, and evaluation of 4-methoxy-phenylthiazole-2-amine derivatives as acetylcholinesterase inhibitors - Zhan_2019_Med.Chem.Res_28_1683 |
| Author(s) : Zhang XZ , Xu Y , Jian MM , Yang K , Ma ZY |
| Ref : Med Chem Res , 28 :1683 , 2019 |
| Abstract : |
| PubMedSearch : Zhan_2019_Med.Chem.Res_28_1683 |
| PubMedID: |
| Title : [Design, synthesis and evaluation of N-acyl-4-phenylthiazole-2-amines as acetylcholinesterase inhibitors] - Ma_2014_Yao.Xue.Xue.Bao_49_813 |
| Author(s) : Ma ZY , Yang Q , Zhang YG , Li JJ , Yang GL |
| Ref : Yao Xue Xue Bao , 49 :813 , 2014 |
| Abstract : |
| PubMedSearch : Ma_2014_Yao.Xue.Xue.Bao_49_813 |
| PubMedID: 25212025 |