Chalcone-piperazine-Cpd4g
IC50: AChE 0.027 +/- 0.001 microM; Monoamine oxidase B (MAO B) 0.114 +/- 0.003 microM
General
Type : Monoamine-oxidase-inhibitor, Multitarget, Piperazine, Dimethoxyphenyl
Chemical_Nomenclature : 2-(4-Acetylpiperazin-1-yl)-N-(4-(3-(3,4-dimethoxyphenyl)-3-oxoprop-1-en-1-yl)phenyl)acetamide
Canonical SMILES : C1=CC(=CC=C1C=CC(C2=CC(=C(C=C2)OC)OC)=O)NC(CN3CCN(CC3)C(C)=O)=O
InChI : InChI=1S\/C25H29N3O5\/c1-18(29)28-14-12-27(13-15-28)17-25(31)26-21-8-4-19(5-9-21)6-10-22(30)20-7-11-23(32-2)24(16-20)33-3\/h4-11,16H,12-15,17H2,1-3H3,(H,26,31)
InChIKey : KAOSNMFKMNTXFM-UHFFFAOYSA-N
Other name(s) : Compound 4g
Target
Families : Chalcone-piperazine-Cpd4g ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Structure-based design, synthesis, and biological activity evaluation of chalcone-piperazine derivatives as dual AChE and MAO B inhibitors - Kurban_2025_RSC.Adv_15_40897 |
| Author(s) : Kurban B , Saglik Ozkan BN , Osmaniye D , Levent S , Ozkay Y , Kaplancikli ZA |
| Ref : RSC Adv , 15 :40897 , 2025 |
| Abstract : |
| PubMedSearch : Kurban_2025_RSC.Adv_15_40897 |
| PubMedID: 41163844 |