Chloro-benzimidazol-phenyl-ethyl-triazol-thio-dihydroxyphenyl-ethanone
AChE IC50 20nM the IC50 for fluoro derivative is 140nM
General
Type : Benzimidazole, Triazol, Dihydroxyphenyl, Sulfur Compound
Chemical_Nomenclature : 2-{5-[4-(5-chloro-1H-1,3-benzimidazol-2-yl)phenyl]-4-ethyl-4H-1,2,4-triazol-3-ylthio}-1-(3,4-dihydroxyphenyl)ethan-1-one
Canonical SMILES : N1=C([N](C(=N1)C2=CC=C(C=C2)C3=NC4=C([N]3)C=CC(=C4)Cl)CC)SCC(=O)C5=CC=C(C(=C5)O)O
InChI : InChI=1S\/C25H20ClN5O3S\/c1-2-31-24(29-30-25(31)35-13-22(34)16-7-10-20(32)21(33)11-16)15-5-3-14(4-6-15)23-27-18-9-8-17(26)12-19(18)28-23\/h3-12,32-33H,2,13H2,1H3,(H,27,28)
InChIKey : DTCGIKUBEORJAY-UHFFFAOYSA-N
Other name(s) : Compound 4 || 2-{5-[p-(5-Chloro-1H-1,3-benzimidazol-2-yl)phenyl]-4-ethyl-4H-1,2,4-triazol-3-ylthio}-1-(3,4-dihydroxyphenyl)-1-ethanone
Target
Families : Chloro-benzimidazol-phenyl-ethyl-triazol-thio-dihydroxyphenyl-ethanone ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Synthesis and Pharmacological Evaluation of Novel 1,5-Disubstituted-3-amino-1,2,4-triazoles Designed as Multitarget Directed Ligands for Alzheimer's Disease Targets - Franco_2026_ACS.Omega_11_13184 |
| Author(s) : Franco DP , Caruso L , Grillo DCN , Nadur NF , de Azevedo LL , Pereira TM , da Silva MC , Lacerda RB , Pinheiro PSM , Riger CJ , Kummerle AE |
| Ref : ACS Omega , 11 :13184 , 2026 |
| Abstract : |
| PubMedSearch : Franco_2026_ACS.Omega_11_13184 |
| PubMedID: 41799150 |