| Title : Design, Synthesis, and Biological Evaluation of Novel Multitarget 7-Alcoxyamino-3-(1,2,3-triazole)-coumarins as Potent Acetylcholinesterase Inhibitors - Nadur_2025_Pharmaceuticals.(Basel)_18_1398 |
| Author(s) : Nadur NF , Ferreira LAP , Franco DP , de Azevedo LL , Caruso L , Honorio TDS , Furtado PS , Simon A , Cabral LM , Werner T , Stark H , Kummerle AE |
| Ref : Pharmaceuticals (Basel) , 18 :1398 , 2025 |
| Abstract : |
| PubMedSearch : Nadur_2025_Pharmaceuticals.(Basel)_18_1398 |
| PubMedID: 41011265 |
| Title : Design, Synthesis, and Biological Evaluation of Novel Multitarget 7-Alcoxyamino-3-(1,2,3-triazole)-coumarins as Potent Acetylcholinesterase Inhibitors - Nadur_2025_Pharmaceuticals.(Basel)_18_1398 |
| Author(s) : Nadur NF , Ferreira LAP , Franco DP , de Azevedo LL , Caruso L , Honorio TDS , Furtado PS , Simon A , Cabral LM , Werner T , Stark H , Kummerle AE |
| Ref : Pharmaceuticals (Basel) , 18 :1398 , 2025 |
| Abstract : |
| PubMedSearch : Nadur_2025_Pharmaceuticals.(Basel)_18_1398 |
| PubMedID: 41011265 |
| Title : Design, Synthesis, and Biological Evaluation of Novel Multitarget 7-Alcoxyamino-3-(1,2,3-triazole)-coumarins as Potent Acetylcholinesterase Inhibitors - Nadur_2025_Pharmaceuticals.(Basel)_18_1398 |
| Author(s) : Nadur NF , Ferreira LAP , Franco DP , de Azevedo LL , Caruso L , Honorio TDS , Furtado PS , Simon A , Cabral LM , Werner T , Stark H , Kummerle AE |
| Ref : Pharmaceuticals (Basel) , 18 :1398 , 2025 |
| Abstract : |
| PubMedSearch : Nadur_2025_Pharmaceuticals.(Basel)_18_1398 |
| PubMedID: 41011265 |
| Title : Discovery of novel thiosemicarbazone-acridine targeting butyrylcholinesterase with antioxidant, metal complexing and neuroprotector abilities as potential treatment of Alzheimer's disease: In vitro, in vivo, and in silico studies - Silva_2024_Eur.J.Med.Chem_281_117030 |
| Author(s) : Silva Sousa GL , Nadur NF , de Almeida Peixoto Ferreira L , da Silva Honorio T , Simon A , Cabral LM , Mora Santos ML , Andrade B , de Lima EV , Clarke JR , Castro RN , Olimpio de Moura R , Kummerle AE |
| Ref : Eur Journal of Medicinal Chemistry , 281 :117030 , 2024 |
| Abstract : |
| PubMedSearch : Silva_2024_Eur.J.Med.Chem_281_117030 |
| PubMedID: 39531933 |
| Title : Discovery of novel thiosemicarbazone-acridine targeting butyrylcholinesterase with antioxidant, metal complexing and neuroprotector abilities as potential treatment of Alzheimer's disease: In vitro, in vivo, and in silico studies - Silva_2024_Eur.J.Med.Chem_281_117030 |
| Author(s) : Silva Sousa GL , Nadur NF , de Almeida Peixoto Ferreira L , da Silva Honorio T , Simon A , Cabral LM , Mora Santos ML , Andrade B , de Lima EV , Clarke JR , Castro RN , Olimpio de Moura R , Kummerle AE |
| Ref : Eur Journal of Medicinal Chemistry , 281 :117030 , 2024 |
| Abstract : |
| PubMedSearch : Silva_2024_Eur.J.Med.Chem_281_117030 |
| PubMedID: 39531933 |
| Title : Discovery of novel thiosemicarbazone-acridine targeting butyrylcholinesterase with antioxidant, metal complexing and neuroprotector abilities as potential treatment of Alzheimer's disease: In vitro, in vivo, and in silico studies - Silva_2024_Eur.J.Med.Chem_281_117030 |
| Author(s) : Silva Sousa GL , Nadur NF , de Almeida Peixoto Ferreira L , da Silva Honorio T , Simon A , Cabral LM , Mora Santos ML , Andrade B , de Lima EV , Clarke JR , Castro RN , Olimpio de Moura R , Kummerle AE |
| Ref : Eur Journal of Medicinal Chemistry , 281 :117030 , 2024 |
| Abstract : |
| PubMedSearch : Silva_2024_Eur.J.Med.Chem_281_117030 |
| PubMedID: 39531933 |
| Title : Structure-based design of new N-benzyl-piperidine derivatives as multitarget-directed AChE\/BuChE inhibitors for Alzheimer's disease - Conceicao_2023_J.Cell.Biochem__ |
| Author(s) : Conceicao RAD , von Ranke N , Azevedo L , Franco D , Nadur NF , Kummerle AE , Barbosa MLC , Souza AMT |
| Ref : Journal of Cellular Biochemistry , : , 2023 |
| Abstract : |
| PubMedSearch : Conceicao_2023_J.Cell.Biochem__ |
| PubMedID: 37796142 |
| Title : Structure-based design of new N-benzyl-piperidine derivatives as multitarget-directed AChE\/BuChE inhibitors for Alzheimer's disease - Conceicao_2023_J.Cell.Biochem__ |
| Author(s) : Conceicao RAD , von Ranke N , Azevedo L , Franco D , Nadur NF , Kummerle AE , Barbosa MLC , Souza AMT |
| Ref : Journal of Cellular Biochemistry , : , 2023 |
| Abstract : |
| PubMedSearch : Conceicao_2023_J.Cell.Biochem__ |
| PubMedID: 37796142 |
| Title : Structure-based design of new N-benzyl-piperidine derivatives as multitarget-directed AChE\/BuChE inhibitors for Alzheimer's disease - Conceicao_2023_J.Cell.Biochem__ |
| Author(s) : Conceicao RAD , von Ranke N , Azevedo L , Franco D , Nadur NF , Kummerle AE , Barbosa MLC , Souza AMT |
| Ref : Journal of Cellular Biochemistry , : , 2023 |
| Abstract : |
| PubMedSearch : Conceicao_2023_J.Cell.Biochem__ |
| PubMedID: 37796142 |
| Title : Design, synthesis, and biological evaluation of new thalidomide-donepezil hybrids as neuroprotective agents targeting cholinesterases and neuroinflammation - Cristancho_2022_RSC.Med.Chem_13_568 |
| Author(s) : Cristancho Ortiz CJ , de Freitas Silva M , Pruccoli L , Fonseca Nadur N , de Azevedo LL , Kummerle AE , Guedes IA , Dardenne LE , Leomil Coelho LF , Guimaraes MJ , da Silva FMR , Castro N , Gontijo VS , Rojas VCT , de Oliveira MK , Vilela FC , Giusti-Paiva A , Barbosa G , Lima LM , Pinheiro GB , Veras LG , Mortari MR , Tarozzi A , Viegas C, Jr. |
| Ref : RSC Med Chem , 13 :568 , 2022 |
| Abstract : |
| PubMedSearch : Cristancho_2022_RSC.Med.Chem_13_568 |
| PubMedID: 35694691 |
| Title : Design, synthesis, and biological evaluation of new thalidomide-donepezil hybrids as neuroprotective agents targeting cholinesterases and neuroinflammation - Cristancho_2022_RSC.Med.Chem_13_568 |
| Author(s) : Cristancho Ortiz CJ , de Freitas Silva M , Pruccoli L , Fonseca Nadur N , de Azevedo LL , Kummerle AE , Guedes IA , Dardenne LE , Leomil Coelho LF , Guimaraes MJ , da Silva FMR , Castro N , Gontijo VS , Rojas VCT , de Oliveira MK , Vilela FC , Giusti-Paiva A , Barbosa G , Lima LM , Pinheiro GB , Veras LG , Mortari MR , Tarozzi A , Viegas C, Jr. |
| Ref : RSC Med Chem , 13 :568 , 2022 |
| Abstract : |
| PubMedSearch : Cristancho_2022_RSC.Med.Chem_13_568 |
| PubMedID: 35694691 |
| Title : Design, synthesis, and biological evaluation of new thalidomide-donepezil hybrids as neuroprotective agents targeting cholinesterases and neuroinflammation - Cristancho_2022_RSC.Med.Chem_13_568 |
| Author(s) : Cristancho Ortiz CJ , de Freitas Silva M , Pruccoli L , Fonseca Nadur N , de Azevedo LL , Kummerle AE , Guedes IA , Dardenne LE , Leomil Coelho LF , Guimaraes MJ , da Silva FMR , Castro N , Gontijo VS , Rojas VCT , de Oliveira MK , Vilela FC , Giusti-Paiva A , Barbosa G , Lima LM , Pinheiro GB , Veras LG , Mortari MR , Tarozzi A , Viegas C, Jr. |
| Ref : RSC Med Chem , 13 :568 , 2022 |
| Abstract : |
| PubMedSearch : Cristancho_2022_RSC.Med.Chem_13_568 |
| PubMedID: 35694691 |
| Title : Design, Synthesis and Biological Evaluation of Novel Triazole N-acylhydrazone Hybrids for Alzheimer's Disease - de Freitas Silva_2020_Molecules_25_ |
| Author(s) : de Freitas Silva M , Tardelli Lima E , Pruccoli L , Castro NG , Guimares MJR , F MRdS , Fonseca Nadur N , de Azevedo LL , Kummerle AE , Guedes IA , Dardenne LE , Gontijo VS , Tarozzi A , Viegas C |
| Ref : Molecules , 25 : , 2020 |
| Abstract : |
| PubMedSearch : de Freitas Silva_2020_Molecules_25_ |
| PubMedID: 32664425 |
| Title : Design, Synthesis and Biological Evaluation of Novel Triazole N-acylhydrazone Hybrids for Alzheimer's Disease - de Freitas Silva_2020_Molecules_25_ |
| Author(s) : de Freitas Silva M , Tardelli Lima E , Pruccoli L , Castro NG , Guimares MJR , F MRdS , Fonseca Nadur N , de Azevedo LL , Kummerle AE , Guedes IA , Dardenne LE , Gontijo VS , Tarozzi A , Viegas C |
| Ref : Molecules , 25 : , 2020 |
| Abstract : |
| PubMedSearch : de Freitas Silva_2020_Molecules_25_ |
| PubMedID: 32664425 |
| Title : Design, Synthesis and Biological Evaluation of Novel Triazole N-acylhydrazone Hybrids for Alzheimer's Disease - de Freitas Silva_2020_Molecules_25_ |
| Author(s) : de Freitas Silva M , Tardelli Lima E , Pruccoli L , Castro NG , Guimares MJR , F MRdS , Fonseca Nadur N , de Azevedo LL , Kummerle AE , Guedes IA , Dardenne LE , Gontijo VS , Tarozzi A , Viegas C |
| Ref : Molecules , 25 : , 2020 |
| Abstract : |
| PubMedSearch : de Freitas Silva_2020_Molecules_25_ |
| PubMedID: 32664425 |
| Title : Discovery of novel dual-active 3-(4-(dimethylamino)phenyl)-7-aminoalcoxy-coumarin as potent and selective acetylcholinesterase inhibitor and antioxidant - de Souza_2019_J.Enzyme.Inhib.Med.Chem_34_631 |
| Author(s) : de Souza GA , da Silva SJ , Del Cistia CN , Pitasse-Santos P , Pires LO , Passos YM , Cordeiro Y , Cardoso CM , Castro RN , Sant'Anna CMR , Kummerle AE |
| Ref : J Enzyme Inhib Med Chem , 34 :631 , 2019 |
| Abstract : |
| PubMedSearch : de Souza_2019_J.Enzyme.Inhib.Med.Chem_34_631 |
| PubMedID: 30727776 |
| Title : Discovery of novel dual-active 3-(4-(dimethylamino)phenyl)-7-aminoalcoxy-coumarin as potent and selective acetylcholinesterase inhibitor and antioxidant - de Souza_2019_J.Enzyme.Inhib.Med.Chem_34_631 |
| Author(s) : de Souza GA , da Silva SJ , Del Cistia CN , Pitasse-Santos P , Pires LO , Passos YM , Cordeiro Y , Cardoso CM , Castro RN , Sant'Anna CMR , Kummerle AE |
| Ref : J Enzyme Inhib Med Chem , 34 :631 , 2019 |
| Abstract : |
| PubMedSearch : de Souza_2019_J.Enzyme.Inhib.Med.Chem_34_631 |
| PubMedID: 30727776 |
| Title : Discovery of novel dual-active 3-(4-(dimethylamino)phenyl)-7-aminoalcoxy-coumarin as potent and selective acetylcholinesterase inhibitor and antioxidant - de Souza_2019_J.Enzyme.Inhib.Med.Chem_34_631 |
| Author(s) : de Souza GA , da Silva SJ , Del Cistia CN , Pitasse-Santos P , Pires LO , Passos YM , Cordeiro Y , Cardoso CM , Castro RN , Sant'Anna CMR , Kummerle AE |
| Ref : J Enzyme Inhib Med Chem , 34 :631 , 2019 |
| Abstract : |
| PubMedSearch : de Souza_2019_J.Enzyme.Inhib.Med.Chem_34_631 |
| PubMedID: 30727776 |
| Title : Structural insights into cholinesterases inhibition by harmane beta-carbolinium derivatives: a kinetics-molecular modeling approach - Torres_2012_Phytochemistry_81_24 |
| Author(s) : Torres JM , Lira AF , Silva DR , Guzzo LM , Sant'Anna CM , Kummerle AE , Rumjanek VM |
| Ref : Phytochemistry , 81 :24 , 2012 |
| Abstract : |
| PubMedSearch : Torres_2012_Phytochemistry_81_24 |
| PubMedID: 22717507 |
| Title : Structural insights into cholinesterases inhibition by harmane beta-carbolinium derivatives: a kinetics-molecular modeling approach - Torres_2012_Phytochemistry_81_24 |
| Author(s) : Torres JM , Lira AF , Silva DR , Guzzo LM , Sant'Anna CM , Kummerle AE , Rumjanek VM |
| Ref : Phytochemistry , 81 :24 , 2012 |
| Abstract : |
| PubMedSearch : Torres_2012_Phytochemistry_81_24 |
| PubMedID: 22717507 |
| Title : Structural insights into cholinesterases inhibition by harmane beta-carbolinium derivatives: a kinetics-molecular modeling approach - Torres_2012_Phytochemistry_81_24 |
| Author(s) : Torres JM , Lira AF , Silva DR , Guzzo LM , Sant'Anna CM , Kummerle AE , Rumjanek VM |
| Ref : Phytochemistry , 81 :24 , 2012 |
| Abstract : |
| PubMedSearch : Torres_2012_Phytochemistry_81_24 |
| PubMedID: 22717507 |