Cyanophenyl-quinazolinthioacetamide-Cpd3e
IC50 AChE 9.26 nM
General
Type : Quinazoline, Sulfur Compound, Cyanide
Chemical_Nomenclature : N-(4-cyanophenyl)-2-(4-oxo-3-phenylquinazolin-2-yl)sulfanylacetamide
Canonical SMILES : C1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3N=C2SCC(=O)NC4=CC=C(C=C4)C#N
InChI : InChI=1S\/C23H16N4O2S\/c24-14-16-10-12-17(13-11-16)25-21(28)15-30-23-26-20-9-5-4-8-19(20)22(29)27(23)18-6-2-1-3-7-18\/h1-13H,15H2,(H,25,28)
InChIKey : QOKUUGWHPPXVAM-UHFFFAOYSA-N
Other name(s) : N-(4-Cyanophenyl)-2-[(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)thio]acetamide || Compound 3e
MW : 412.5
Formula : C23H16N4O2S
CAS_number :
PubChem : 2360492
UniChem : QOKUUGWHPPXVAM-UHFFFAOYSA-N
Target
Families : Cyanophenyl-quinazolinthioacetamide-Cpd3e ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Donepezil-based rational design of N-substituted quinazolinthioacetamide candidates as potential acetylcholine esterase inhibitors for the treatment of Alzheimer's disease: in vitro and in vivo studies - Al-Karmalawy_2025_RSC.Med.Chem__ |
| Author(s) : Al-Karmalawy AA , Mohamed AF , Shalaby HN , Elmaaty AA , El-Shiekh RA , Zeidan MA , Alnajjar R , Alzahrani AYA , Al Mughram MH , Shaldam MA , Tawfik HO |
| Ref : RSC Med Chem , : , 2025 |
| Abstract : |
| PubMedSearch : Al-Karmalawy_2025_RSC.Med.Chem__ |
| PubMedID: 40027342 |