Dichlorophenyl-sulfonyl-hydrazone-dichlorobenzene-sulfonate-ester-Cpd4
hCA I IC50 (nM) 25.56; hCA II IC50 (nM) 139.72; AChE IC50 (nM) 10.68; hCA I Ki (nM) 26.66 +/- 12.11; hCA II Ki (nM) 18.53 +/- 8.5; AChE Ki (nM) 9.58 +/- 2.22
General
Type : Multitarget, Carbonic anhydrase inhibitor, Sulfur Compound
Chemical_Nomenclature : 4-((2-((2,5-Dichlorophenyl)Sulfonyl)Hydrazineylidene)Methyl)Phenyl-2,5-Dichloro Benzenesulfonate
Canonical SMILES : C1=C(C=C(C=C1Cl)[S](NN=CC2=CC=C(C=C2)O[S](C3=CC(=CC(=C3)Cl)Cl)(=O)=O)(=O)=O)Cl
InChI : 1S\/C19H12Cl4N2O5S2\/c20-13-5-14(21)8-18(7-13)31(26,27)25-24-11-12-1-3-17(4-2-12)30-32(28,29)19-9-15(22)6-16(23)10-19\/h1-11,25H
InChIKey : CXIFUPPURJKFLR-UHFFFAOYSA-N
Other name(s) : Compound 4
Target
Families : Dichlorophenyl-sulfonyl-hydrazone-dichlorobenzene-sulfonate-ester-Cpd4 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Novel Sulfonylhydrazones With Sulfonate Ester Framework: Promising Dual Inhibitors of AChE and hCAs - Ozturk_2025_Biotechnol.Appl.Biochem__e2780 |
| Author(s) : Ozturk C , Balci N , Aslan ON , Kalay E |
| Ref : Biotechnol Appl Biochem , :e2780 , 2025 |
| Abstract : |
| PubMedSearch : Ozturk_2025_Biotechnol.Appl.Biochem__e2780 |
| PubMedID: 40320825 |