Difluorophenyl-C3-amino-galantamine-Cpd6l
eqBChE, IC50 0.88 microM
General
Type : Derivative of Galanthamine, Alkaloid, Natural_modified
Chemical_Nomenclature : (12S,14R)-9-(3,5-Difluorophenylamino)-4-methyl-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraen-14-ol
Canonical SMILES : C12=C3CN(CC|C15[C@@H](OC2=C(C=C3)NC4=CC(=CC(=C4)F)F)C[C@H](C=C5)O)C
InChI : InChI=1S\/C22H20F2N2O2\/c1-3-26(2)12-13-4-7-19(25-16-9-14(23)8-15(24)10-16)22-21(13)18-6-5-17(27)11-20(18)28-22\/h4-10,17,20,25,27H,3,11-12H2,2H3\/t17-,20-\/m0\/s1
InChIKey : XSOONDYGFPIVCD-PXNSSMCTSA-N
Other name(s) : Compound 6l
Target
Families : Difluorophenyl-C3-amino-galantamine-Cpd6l ligand of proteins in family
BCHE
Protein :
human-BCHE
References (1)
| Title : Novel C3-Aminated Galantamine Derivatives as Selective Butyrylcholinesterase Inhibitors With Neuroprotective Effects - Tang_2026_ChemMedChem_21_e70431 |
| Author(s) : Tang FL , Huang LJ , Wang YX , Wang SM , Ji WS , Gao F , Sun L , Xu JB |
| Ref : ChemMedChem , 21 :e70431 , 2026 |
| Abstract : |
| PubMedSearch : Tang_2026_ChemMedChem_21_e70431 |
| PubMedID: 42603776 |