Dimethoxyphenyl-pyrrolidin-butoxyphenyl-thiazol-acetamide
IC50 ACHE compound 4f 0.66 microM
General
Type : Sulfur Compound, Thiazole, Pyrrolidine, Dimethoxyphenyl
Chemical_Nomenclature : 2-(3,4-dimethoxyphenyl)-N-(4-(4-(4-(pyrrolidin-1-yl)butoxy)phenyl)thiazol-2-yl)acetamide
Canonical SMILES : N4(CCCCOC1=CC=C(C=C1)C2=CSC(=N2)NC(CC3=CC=C(C(=C3)OC)OC)=O)CCCC4
InChI : InChI=1S\/C27H33N3O4S\/c1-32-24-12-7-20(17-25(24)33-2)18-26(31)29-27-28-23(19-35-27)21-8-10-22(11-9-21)34-16-6-5-15-30-13-3-4-14-30\/h7-12,17,19H,3-6,13-16,18H2,1-2H3,(H,28,29,31)
InChIKey : KUILTRQEFGYMOG-UHFFFAOYSA-N
Other name(s) : Compound 4f
Target
Families : Dimethoxyphenyl-pyrrolidin-butoxyphenyl-thiazol-acetamide ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Design, synthesis and evaluation of new 4-arylthiazole-2-amine derivatives as acetylcholinesterase inhibitors - Xu_2020_Bioorg.Med.Chem.Lett_30_126985 |
| Author(s) : Xu Y , Jian MM , Han C , Yang K , Bai LG , Cao F , Ma ZY |
| Ref : Bioorganic & Medicinal Chemistry Lett , 30 :126985 , 2020 |
| Abstract : |
| PubMedSearch : Xu_2020_Bioorg.Med.Chem.Lett_30_126985 |
| PubMedID: 32008906 |