Dimethylamino-dimethylpyrazino-pyrrolo-pyrimidin-one
AChE IC50 0.22 +/- 0.02 MicroM, mixed-type inhibition
General
Type : Pyrimidine, Pyrazole
Chemical_Nomenclature : 4-(dimethylamino)-7,8-dimethylpyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin-6(7H)-one
Canonical SMILES : N1=CN=C2C(=C1N(C)C)C=C3[N]2C=C(N(C3=O)C)C
InChI : InChI=1S\/C13H15N5O\/c1-8-6-18-10(13(19)17(8)4)5-9-11(16(2)3)14-7-15-12(9)18\/h5-7H,1-4H3
InChIKey : WTGDYIUIOMNWTF-UHFFFAOYSA-N
Other name(s) : Compound 22
Target
Families : Dimethylamino-dimethylpyrazino-pyrrolo-pyrimidin-one ligand of proteins in family
ACHE
Protein :
human-ACHE
References (3)
| Title : Design, synthesis and evaluation of new pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidines as tacrine-like acetylcholinesterase inhibitors - Muzychka_2026_RSC.Adv_16_2417 |
| Author(s) : Muzychka LV , Muzychka OV , Kobzar OL , Vovk AI , Smolii OB |
| Ref : RSC Adv , 16 :2417 , 2026 |
| Abstract : |
| PubMedSearch : Muzychka_2026_RSC.Adv_16_2417 |
| PubMedID: 41531526 |
| Title : Design, synthesis and evaluation of new pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidines as tacrine-like acetylcholinesterase inhibitors - Muzychka_2026_RSC.Adv_16_2417 |
| Author(s) : Muzychka LV , Muzychka OV , Kobzar OL , Vovk AI , Smolii OB |
| Ref : RSC Adv , 16 :2417 , 2026 |
| Abstract : |
| PubMedSearch : Muzychka_2026_RSC.Adv_16_2417 |
| PubMedID: 41531526 |
| Title : Design, synthesis and evaluation of new pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidines as tacrine-like acetylcholinesterase inhibitors - Muzychka_2026_RSC.Adv_16_2417 |
| Author(s) : Muzychka LV , Muzychka OV , Kobzar OL , Vovk AI , Smolii OB |
| Ref : RSC Adv , 16 :2417 , 2026 |
| Abstract : |
| PubMedSearch : Muzychka_2026_RSC.Adv_16_2417 |
| PubMedID: 41531526 |