Disulfiram
A multi-enzyme inhibitor used in alcohol aversion therapy. Has anticancer properties. It has a role as an EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor, an angiogenesis inhibitor, an EC 3.1.1.8 (cholinesterase) inhibitor, an EC 3.1.1.1 (carboxylesterase) inhibitor, an EC 5.99.1.2 (DNA topoisomerase) inhibitor, a fungicide, an apoptosis inducer, a NF-kappaB inhibitor and an organosulfur acaricide.
General
Type : Sulfur Compound
Chemical_Nomenclature : diethylcarbamothioylsulfanyl N,N-diethylcarbamodithioate
Canonical SMILES : CCN(CC)C(=S)SSC(=S)N(CC)CC
InChI : InChI=1S\/C10H20N2S4\/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4\/h5-8H2,1-4H3
InChIKey : AUZONCFQVSMFAP-UHFFFAOYSA-N
Other name(s) : ((C2H5)2NCS)2S2, Tetraethylthiuram disulfide, Antabuse, Bis(diethylthiocarbamoyl) disulfide
MW : 296.5
Formula : C10H20N2S4
CAS_number : 97-77-8
PubChem : 3117
UniChem : AUZONCFQVSMFAP-UHFFFAOYSA-N
Target
Families : Disulfiram ligand of proteins in family
Monoglyceridelipase_lysophospholip
Protein :
human-MGLL
References (2)
| Title : New Disulfiram Derivatives as MAGL-Selective Inhibitors - Omran_2021_Molecules_26_ |
| Author(s) : Omran Z |
| Ref : Molecules , 26 : , 2021 |
| PubMedID: 34070869 |
| Title : Disulfiram is an inhibitor of human purified monoacylglycerol lipase, the enzyme regulating 2-arachidonoylglycerol signaling - Labar_2007_Chembiochem_8_1293 |
| Author(s) : Labar G , Bauvois C , Muccioli GG , Wouters J , Lambert DM |
| Ref : Chembiochem , 8 :1293 , 2007 |
| PubMedID: 17579916 |
| Gene_locus related to this paper: human-MGLL |