ERX-208
ERX 208 induces endoplasmic reticulum stress and suppresses DNA damage repair to enhance chemotherapy sensitivity.
General
Type : Oligobenzamide
Chemical_Nomenclature : 3-(2-hydroxyethoxy)-N-(2-isobutoxy-4-((2-isobutoxy-4-((trans-4-(quinolin-3-ylcarbamoyl)cyclohexyl)carbamoyl)phenyl)carbamoyl)phenyl)-4-nitrobenzamide || 4-[[4-[[3-(2-hydroxyethoxy)-4-nitrobenzoyl]amino]-3-(2-methylpropoxy)benzoyl]amino]-3-(2-methylpropoxy)-N-[4-(quinolin-3-ylcarbamoyl)cyclohexyl]benzamide
Canonical SMILES : CC(C)COC1=C(C=CC(=C1)C(=O)NC2CCC(CC2)C(=O)NC3=CC4=CC=CC=C4N=C3)NC(=O)C5=CC(=C(C=C5)NC(=O)C6=CC(=C(C=C6)[N+](=O)[O-])OCCO)OCC(C)C
InChI : InChI=1S\/C47H52N6O10\/c1-28(2)26-62-41-22-32(45(56)49-35-14-9-30(10-15-35)44(55)50-36-21-31-7-5-6-8-37(31)48-25-36)11-16-38(41)51-46(57)33-12-17-39(42(23-33)63-27-29(3)4)52-47(58)34-13-18-40(53(59)60)43(24-34)61-20-19-54\/h5-8,11-13,16-18,21-25,28-30,35,54H,9-10,14-15,19-20,26-27H2,1-4H3,(H,49,56)(H,50,55)(H,51,57)(H,52,58)
InChIKey : ISYBVHATWDWXFR-UHFFFAOYSA-N
Other name(s) : SCHEMBL24211255 || ERX-208
MW : 860.9
Formula : C47H52N6O10
CAS_number :
PubChem : 153603628
UniChem : ISYBVHATWDWXFR-UHFFFAOYSA-N
Target
Families : ERX-208 ligand of proteins in family
Acidic_Lipase
Protein :
human-LIPA
References (2)
| Title : Therapeutic optimization of LIPA targeting to induce endoplasmic reticulum stress and cell death in ovarian cancer - Viswanadhapalli_2026_Oncogene_45_790 |
| Author(s) : Viswanadhapalli S , Lee TK , Elmore S , Sharma G , Gopalam R , Panneerdoss DM , Liu X , Parra K , Reese T , Hsieh M , Pratap UP , Yang X , Ebrahimi B , Li X , Neal H , Chen CY , Kassees K , Cervantes C , Baker A , Subbarayalu P , Ramirez P , Lyons YA , Lai Z , Chen Y , Boerma JW , LoCoco PM , Clanton NA , Xu Z , Rao M , Rao TR , Kost E , Sareddy GR , Raj GV , Ahn JM , Vadlamudi RK |
| Ref : Oncogene , 45 :790 , 2026 |
| Abstract : |
| PubMedSearch : Viswanadhapalli_2026_Oncogene_45_790 |
| PubMedID: 41651987 |
| Title : ERX 208 induces endoplasmic reticulum stress and suppresses DNA damage repair to enhance chemotherapy sensitivity - Panneerdoss_2026_Cancer.Res.Commun__ |
| Author(s) : Panneerdoss DM , Nassar KM , Subramani B , Arnold WC , Vedagiri Venkata SP , Hernandez J , Ebrahimi B , Chaudhari SR , Sharma G , Lee TK , Elmore S , Neal H , Pratap UP , Sareddy GR , Kost ER , Ahn JM , Raj GV , Vadlamudi RK |
| Ref : Cancer Research Commun , : , 2026 |
| Abstract : |
| PubMedSearch : Panneerdoss_2026_Cancer.Res.Commun__ |
| PubMedID: 42842296 |