Isolated from Lysimachia punctata and Embelia ribes. Antimicrobial, antineoplastic and inhibitory activity towards hepatitis C protease. IC50 AChE 49.61 microg/ml
Type : Multitarget, Not A\/B H target, Natural
Chemical_Nomenclature : 2,5-dihydroxy-3-undecylcyclohexa-2,5-diene-1,4-dione
Canonical SMILES : CCCCCCCCCCCC1=C(C(=O)C=C(C1=O)O)O
InChI : InChI=1S\/C17H26O4\/c1-2-3-4-5-6-7-8-9-10-11-13-16(20)14(18)12-15(19)17(13)21\/h12,18,21H,2-11H2,1H3
InChIKey : IRSFLDGTOHBADP-UHFFFAOYSA-N
Other name(s) : Embelic acid || 2,5-dihydroxy-3-undecylcyclohexa-2,5-diene-1,4-dione || 2,5-dihydroxy-3-undecyl-1,4-benzoquinone || Emberine
MW : 294.4
Formula : C17H26O4
CAS_number : 550-24-3
PubChem : 3218
UniChem : IRSFLDGTOHBADP-UHFFFAOYSA-N
Title : Neuroprotective effects of Embelin in an ethidium bromide-induced multiple sclerosis in rats: Modulation of p38 MAPK signaling pathway - Anika_2024_Int.Immunopharmacol_129_111639 |
Author(s) : Anika , Singh S , Rimpi |
Ref : Int Immunopharmacol , 129 :111639 , 2024 |
Abstract : |
PubMedSearch : Anika_2024_Int.Immunopharmacol_129_111639 |
PubMedID: 38335654 |
Title : Protective effects of Embelin in Benzo[alpha]pyrene induced cognitive and memory impairment in experimental model of mice - Goal_2024_Curr.Res.Neurobiol_6_100122 |
Author(s) : Goal A , Raj K , Singh S , Arora R |
Ref : Curr Res Neurobiol , 6 :100122 , 2024 |
Abstract : |
PubMedSearch : Goal_2024_Curr.Res.Neurobiol_6_100122 |
PubMedID: 38616958 |
Title : Design, Synthesis, and Pharmacological Evaluation of Embelin-Aryl\/alkyl Amine Hybrids as Orally Bioavailable Blood-Brain Barrier Permeable Multitargeted Agents with Therapeutic Potential in Alzheimer's Disease: Discovery of SB-1448 - Nuthakki_2023_ACS.Chem.Neurosci_14_1193 |
Author(s) : Nuthakki VK , Choudhary S , Reddy CN , Bhatt S , Jamwal A , Jotshi A , Raghuvanshi R , Sharma A , Thakur S , Jadhav HR , Bharate SS , Nandi U , Kumar A , Bharate SB |
Ref : ACS Chem Neurosci , 14 :1193 , 2023 |
Abstract : |
PubMedSearch : Nuthakki_2023_ACS.Chem.Neurosci_14_1193 |
PubMedID: 36812360 |
Title : Isolation and in-silico approach of Modified Embelin derivative from Embelia ribes fruits as anti-Alzheimer agent - Rupesh_2023_Nat.Prod.Res__1 |
Author(s) : Rupesh R , Mohankumar R , Sabarathinam S |
Ref : Nat Prod Res , :1 , 2023 |
Abstract : |
PubMedSearch : Rupesh_2023_Nat.Prod.Res__1 |
PubMedID: 37690004 |
Title : Mosquitocidal efficacy of embelin and its derivatives against Aedes aegypti L. and Culex quinquefasciatus Say. (Diptera: Culicidae) and computational analysis of acetylcholinesterase 1 (AChE1) inhibition - Stalin_2022_Comput.Biol.Med_146_105535 |
Author(s) : Stalin A , Daniel Reegan A , Rajiv Gandhi M , Saravanan RR , Balakrishna K , Hesham AE , Ignacimuthu S , Zhang Y |
Ref : Computers in Biology & Medicine , 146 :105535 , 2022 |
Abstract : |
PubMedSearch : Stalin_2022_Comput.Biol.Med_146_105535 |
PubMedID: 35487124 |
Title : Embelin, a Potent Molecule for Alzheimer's Disease: A Proof of Concept From Blood-Brain Barrier Permeability, Acetylcholinesterase Inhibition and Molecular Docking Studies - Bhuvanendran_2019_Front.Neurosci_13_495 |
Author(s) : Bhuvanendran S , Hanapi NA , Ahemad N , Othman I , Yusof SR , Shaikh MF |
Ref : Front Neurosci , 13 :495 , 2019 |
Abstract : |
PubMedSearch : Bhuvanendran_2019_Front.Neurosci_13_495 |
PubMedID: 31156375 |
Title : Identification of embelin, a 3-undecyl-1,4-benzoquinone from Embelia ribes as a multitargeted anti-Alzheimer agent - Nuthakki_2019_Drug.Dev.Res_80_655 |
Author(s) : Nuthakki VK , Sharma A , Kumar A , Bharate SB |
Ref : Drug Dev Res , 80 :655 , 2019 |
Abstract : |
PubMedSearch : Nuthakki_2019_Drug.Dev.Res_80_655 |
PubMedID: 31050027 |
Title : Amelioration of Cognitive Deficit by Embelin in a Scopolamine-Induced Alzheimer's Disease-Like Condition in a Rat Model - Bhuvanendran_2018_Front.Pharmacol_9_665 |
Author(s) : Bhuvanendran S , Kumari Y , Othman I , Shaikh MF |
Ref : Front Pharmacol , 9 :665 , 2018 |
Abstract : |
PubMedSearch : Bhuvanendran_2018_Front.Pharmacol_9_665 |
PubMedID: 29988493 |
Title : Embelin Attenuates Intracerebroventricular Streptozotocin-Induced Behavioral, Biochemical, and Neurochemical Abnormalities in Rats - Arora_2017_Mol.Neurobiol_54_6670 |
Author(s) : Arora R , Deshmukh R |
Ref : Molecular Neurobiology , 54 :6670 , 2017 |
Abstract : |
PubMedSearch : Arora_2017_Mol.Neurobiol_54_6670 |
PubMedID: 27744573 |