Eugenol-carbamate-cpdE11
Eugenol is a naturally occurring phenolic molecule found in several plants such as cinnamon, clove, and bay leaves. It has been used as a topical antiseptic as a pain control. E11 AChE IC50 = 0.62 nM)
General
Type : Natural_modified, Carbamate, Piperazine, Carboxylate
Chemical_Nomenclature : 4-allyl-2-methoxyphenyl 4-phenylpiperazine-1-carboxylate
Canonical SMILES : C1(=C(C=C(C=C1)CC=C)OC)OC(N2CCN(CC2)C3=CC=CC=C3)=O
InChI : InChI=1S\/C21H24N2O3\/c1-3-7-17-10-11-19(20(16-17)25-2)26-21(24)23-14-12-22(13-15-23)18-8-5-4-6-9-18\/h3-6,8-11,16H,1,7,12-15H2,2H3
InChIKey : ZALHGMUVKFYREB-UHFFFAOYSA-N
Other name(s) : Compound E11
Target
Families : Eugenol-carbamate-cpdE11 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Eugenol-derived carbamates as sub-nanomolar dual cholinesterase inhibitors with neuroprotective activity against Alzheimer's disease: Structure-activity relationships and molecular dynamics insights - Akca_2026_Bioorg.Chem_180_110233 |
| Author(s) : Akca S , Ilkar Erdagi S , Sari S , Ozbagci DI |
| Ref : Bioorg Chem , 180 :110233 , 2026 |
| Abstract : |
| PubMedSearch : Akca_2026_Bioorg.Chem_180_110233 |
| PubMedID: 42442298 |