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Carbamate

General

Derived from carbamic acid (NH2COOH). Carbamates can also inhibits many enzymes whose catalytic active site contains a nucleophilic Serine. This serine can be carbamylated. The first naturally occurring carbamate discovered was physostigmeine( eserine). Many carbamates were developped as insecticides or nerve agents (inhibitors of cholinesterases) but also in medicine. Polymers whose units are joined by divalent carbamate groups NH(C=O)O are an important family of plastics, the polyurethanes.
Inhibitor Main targeted enzyme families Type Structure
Chlorpropham Carb_B_Bacteria Herbicide Carbamate Not A\/B H target
MP30 BCHE Multitarget Derivative of Rivastigmine Carbamate Antioxidant Sulfur Compound
Acetyl-methoxyphenyl-fluorobenzyl-methyl-carbamate-D12 BCHE Multitarget Carbamate FAAH inhibitor
Tacrine-CA-Activator-Cpd30 ACHE BCHE Carbonic anhydrase activator Carbamate Multitarget Derivative of Tacrine Alkyl linked bis-ligand
JB101 6_AlphaBeta_hydrolase Organophosphate Carbamate Alkyne
Cannabidiol-amide-CB7 BCHE Cannabinoid-Receptor-ligand Multitarget Carbamate Antioxidant
CHEMBL4177075 ACHE Carbamate Quinoline
CHEMBL4177075-INDY ACHE BCHE Multitarget Benzothiazol Carbamate Quinoline
Isosorbide-2-butylcarbamate-5-lipoic-acid-ester BCHE Isosorbide Carbamate Multitarget Antioxidant
Rivastigmine-Donepezil-COR783 ACHE BCHE Cannabinoid-Receptor-ligand Derivative of Rivastigmine Multitarget Sulfur Compound Derivative of Donepezil Carbamate Adamantyl
Xanthostigmine ACHE BCHE Carbamate Xanthene
Tacrine-Sibiriline-Cpd7 BCHE ACHE Multitarget Acridine Derivative of Tacrine Alkyl linked bis-ligand Pyridine Carbamate Pyrrolidine Antioxidant
DECF Carboxylesterase Carb_B_Chordata Carbamate Chromen
ABD-1970 Monoglyceridelipase_lysophospholip Carbamate Trifluoro Piperazine Azabicyclo
Antibacterial-agent-136 Monoglyceridelipase_lysophospholip Hormone-sensitive_lipase_like 6_AlphaBeta_hydrolase Oxadiazol Carbamate
Antibact-product-Oxadiazolone-cp3 6_AlphaBeta_hydrolase Oxadiazol Carbamate
SCHEMBL19582562 ABHD6-Lip Morpholine Carbamate Trifluoro Azaspiro
SCHEMBL20516363 ABHD6-Lip PAF-Acetylhydrolase Piperazine Imidazole Carbamate Morpholine
MJN193 ABHD6-Lip Piperazine Imidazole Carbamate
JZP-430 ABHD6-Lip Carbamate Morpholine Sulfur Compound Thiadiazol
Compound-47 abh_upf0017 Carbamate
CHEMBL4079247 BCHE Carbamate
Meropenem ACPH_Peptidase_S9 Antibiotic Pyrrolidine Carbamate Sulfur Compound
JZP-MA-11 ABHD6-Lip Sulfur Compound PET probe Thiadiazol Piperidine Carbamate
Ethienocarb ACHE Carbamate Insecticide Cyanide
3,3-Dimethylbutyl-N-butylcarbamate BCHE ACHE Carbamate Analogue of substrate
2-trimethylsilyl-ethyl-N-butylcarbamate BCHE ACHE Carbamate Analogue of substrate Sulfur Compound
H-Lys(4-nitro-Z)-pyrrolidide DPP4N_Peptidase_S9 Pyrrolidine Carbamate pNP Peptide
Benzimidazole-Diethylcarbamoyl-isopentyl-dimethylcarbamate-15d BCHE Cannabinoid-Receptor-ligand Benzimidazole Carbamate Carboxamide Multitarget
Benzimidazole-Ethoxybenzyl-isopentyl-azetidine-carboxylate-21d BCHE Cannabinoid-Receptor-ligand Benzimidazole Carbamate Carboxamide Multitarget Azetidin
Benzimidazole-phenyl-azetidine-carboxylate-11d BCHE Cannabinoid-Receptor-ligand Benzimidazole Carbamate Carboxamide Multitarget Azetidin
Cyclohexylmethylcarbamate-phenethylnorphysostigmine-3u BCHE Derivative of physostigmine-eserine Carbamate
Amantadine-M30D-hybrid5e BCHE Monoamine-oxidase-inhibitor Multitarget Carbamate Adamantyl Alkyl linked bis-ligand
M30D ACHE Monoamine-oxidase-inhibitor Multitarget Carbamate Quinoline
Cpd-6-8AI7 BCHE Carbamate Indole Cycloheptyl Derivative of Tryptophan
Cpd-17-Cycloheptyl-Indole-undecyl-carbamate ACHE BCHE Carbamate Indole Cycloheptyl Derivative of Tryptophan Alkyne
N-10-Phenothiazine-2-Pyrrlidinylethyl-carbamate BCHE Phenothiazine Carbamate Sulfur Compound
N-10-Phenothiazine-3-(dimethylamino)phenyl-carbamate BCHE Phenothiazine Carbamate Sulfur Compound
N-10-Phenothiazine-isopropyl-carbamate ACHE BCHE Phenothiazine Carbamate Sulfur Compound
N-10-Phenothiazine-1-Naphtyl-carbamate BCHE Phenothiazine Carbamate Sulfur Compound
Thiobencarb Carbamate Herbicide Sulfur Compound
Bis(N-propylcarbamic-acid)ethylene-ester Bacterial_lip_FamI.1 Carbamate
6H6-Heptyl-Carbamate BCHE Carbamate Derivative of Tryptamine Indole
H327 BCHE Carbamate Derivative of Tryptamine Indole
BChE-IN-3 BCHE Derivative of Tryptophan Indole Carbamate Cycloheptyl Derivative of Tryptamine
Fragment-588 Pectinacetylesterase-Notum Fragment inhibitor of Notum Benzyloxycarbonyl Carbamate
N-methyl-4,5-dihydronaphtho[1,2-b]thiophene-2-carboxamide Pectinacetylesterase-Notum Fragment inhibitor of Notum Sulfur Compound Carboxamide Carbamate Thiophen
MT-031 ACHE BCHE Monoamine-oxidase-inhibitor Multitarget Carbamate prop-2-yn-1-yl
123I-PIP BCHE Carbamate PET probe
T-1123 ACHE Carbamate Chemical Warfare Agent Trimethylammonium Nerve Agent Carbamate
EA-4056 ACHE Carbamate Chemical Warfare Agent Trimethylammonium Bisquaternary Nerve Agent Carbamate Pyridine
EA-3990 ACHE Carbamate Chemical Warfare Agent Trimethylammonium Bisquaternary Nerve Agent Carbamate Pyridine
CHEMBL3585776 ACHE Carbamate Sulfur Compound Sulfonamide Carbonic anhydrase inhibitor Multitarget
JCP678 A85-EsteraseD-FGH Carbamate Sulfur Compound Sulfonyl
SB31184-49R-4Y2U Epoxide_hydrolase Carbamate Quinoline tert-Butyloxycarbonyl tert-Butyl
Cpd35-Rivastigmine-5-HT6 BCHE Derivative of Rivastigmine Multitarget 5-HT-receptor-ligand Sulfur Compound Sulfonamide Indole Carbamate Alkyl linked bis-ligand anti-Abeta-aggregation
WAY-121898 Cholesterol_esterase Carbamate Piperidine Phenoxyphenyl
CBD-carbamate-C16 BCHE Carbamate Cannabinoid-Receptor-ligand Multitarget
ABC47 abh_upf0017 CGI-58_ABHD5_ABHD4 Carbamate Piperidine N-hydroxyhydantoin Phenoxyphenyl
ABC51 CGI-58_ABHD5_ABHD4 Carbamate Piperidine N-hydroxyhydantoin Phenoxyphenyl
JJH251 Carbamate Piperidine N-hydroxyhydantoin
JJH221 Carbamate Piperidine N-hydroxyhydantoin tert-Butyloxycarbonyl tert-Butyl
ABC44 Palmitoyl-protein_thioesterase Carbamate Piperidine N-hydroxyhydantoin
JCP-265 ABHD6-Lip Carbamate Chromen
CHEMBL440526 BCHE ACHE Multitarget Carbamate Coumarin Chromen
Cpd37-Fluoroindol-carbamate Monoglyceridelipase_lysophospholip Multitarget Carbamate Indole FAAH inhibitor Alkyl linked bis-ligand
SPB01403 Monoglyceridelipase_lysophospholip Carbamate FAAH inhibitor Multitarget Sulfur Compound
Idalopirdine-rivastigmine BCHE Drug Pro-Drug Carbamate Derivative of Rivastigmine Multitarget 5-HT-receptor-ligand
CHEMBL1784957 ACHE Drug Pro-Drug Carbamate Derivative of Rivastigmine
5-deoxo-3-hydroxyevodiamine-heptyl-carbamate BCHE Carbamate Natural_modified Derivative of Evodiamine
Tetracyclic-carbamate-cp8 BCHE PET probe Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline
Tetracyclic-carbamate-melatonine-3c BCHE Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline Derivative of Tryptamine Indole Alkyl linked bis-ligand
Tetracyclic-carbamate-ferulicacid-4a BCHE Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline Feruloyl Antioxidant Alkyl linked bis-ligand
Pyranone-carbamate-cpd7p BCHE Carbamate Piperidine Antioxidant
Tetracyclic-carbamate-UW-MD-95 BCHE Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline
CHEMBL4454960 BCHE Morpholine Isoquinoline Carbamate Quinazoline
CHEMBL4454960-PET BCHE PET probe Carbamate
6SAM-cpd13 BCHE Multitarget Piperidine Inden Monoamine-oxidase-inhibitor Carbamate
6EUL-BY2 BCHE Carbamate Derivative of Rivastigmine
RIV-BIMb-5d BCHE Derivative of Rivastigmine Carbamate Benzimidazole
Terbam ACHE Carbamate Insecticide tert-Butyl
Phenolic-deriv-Donecopride-20 ACHE Carbamate Multitarget 5-HT-receptor-ligand Derivative of Donepezil Piperidine
Tetracyclic-carbamate-photoswitch-azo BCHE Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline Photoswitch
Salicylic-donepezil-rivastigmine-5a BCHE Carbamate Derivative of Donepezil Salicylic Derivative of Rivastigmine
N-acyl-prolylpyrrolidine-inhibitor-2 S9N_PPCE_Peptidase_S9 Pyrrolidine Triazol Carbamate tert-Butyloxycarbonyl tert-Butyl
PF-06795071 Monoglyceridelipase_lysophospholip Trifluoro Carbamate PET probe Pyrazole Azabicyclo
Z-Pro-Prolinal-derived S9N_PPCE_Peptidase_S9 Benzyloxycarbonyl Piperidine Peptide Pyrrolidine Carboxamide Carbamate
6AX1-cp3 Monoglyceridelipase_lysophospholip Halo ketone Trifluoro Carbamate Azetidin Oxadiazol
Molinate Carbamate Herbicide Sulfur Compound Azepane Not A\/B H target
Z-Gly-Gly-Phe-chloromethyl-ketone ACPH_Peptidase_S9 Benzyloxycarbonyl Carbamate Peptide Ketone Carboxamide
PNPMPC ACPH_Peptidase_S9 pNP Carbamate
p-nitrophenyl-N-butyl-carbamate Cholesterol_esterase pNP Carbamate
3-Cholesteryl-N-butylcarbamate Cholesterol_esterase Carbamate Steroid Phenanthrene Lipase inhibitor
3-Cholesteryl-N-octylcarbamate Cholesterol_esterase Carbamate Steroid Phenanthrene Lipase inhibitor
p-nitrophenyl-N-butyl-N-methyl-carbamate Cholesterol_esterase pNP Carbamate
p-nitrophenyl-N-octyl-carbamate Cholesterol_esterase pNP Carbamate
PNPPC ACPH_Peptidase_S9 pNP Carbamate
URB602 Monoglyceridelipase_lysophospholip Biphenyl Carbamate
AM9928 Monoglyceridelipase_lysophospholip Piperazine Fluoren Carbamate
ABC99 Pectinacetylesterase-Notum Pyridine Carbamate
SA-57 Monoglyceridelipase_lysophospholip Carbamate Piperidine
MJN110 Monoglyceridelipase_lysophospholip Plasmodium_subtelomeric_PST-A Carbamate Piperazine Pyrrolidine
CAY10499 Monoglyceridelipase_lysophospholip Carb_B_Chordata ABHD6-Lip Lipase_3 Hormone-sensitive_lipase_like Carbamate Oxadiazol
Indol-adamantyl-carbamate-Cpd42 DPP4N_Peptidase_S9 Gliptin Adamantyl Carbamate Indole
Indol-adamantyl-carbamate-Nitrobenzooxadiazol-Cpd20 DPP4N_Peptidase_S9 Gliptin Adamantyl Carbamate Indole Oxadiazol NBD-nitro-benzoxadiazol-fluorescent Benzoxadiazole
CHEMBL49895 Hormone-sensitive_lipase_like Carbamate tert-Butyl Morpholine
Z-Pro-Prolinal S9N_PPCE_Peptidase_S9 Benzyloxycarbonyl Peptide Pyrrolidine Carbamate
Quinazolin-carbamate-2p BCHE Quinazoline Carbamate Sulfur Compound Thiophen
CHEMBL238787 Hormone-sensitive_lipase_like Carb_B_Chordata ABHD6-Lip Trifluoro Carbamate Piperidine
JW651 Monoglyceridelipase_lysophospholip Plasmodium_subtelomeric_PST-A Piperazine Halo ketone Carbamate Trifluoro
DO34 Lipase_3 Trifluoro Piperazine Carbamate tert-Butyloxycarbonyl tert-Butyl
Rhc80267 Lipase_3 Carb_B_Chordata ABHD6-Lip Hormone-sensitive_lipase_like Monoglyceridelipase_lysophospholip Carbamate
QST-0837 Monoglyceridelipase_lysophospholip PET probe Carbamate Trifluoro Azetidin Pyrazole
ABX-1431 Monoglyceridelipase_lysophospholip Piperazine Carbamate Pyrrolidine Trifluoro
KML29 Monoglyceridelipase_lysophospholip Plasmodium_subtelomeric_PST-A Halo ketone Piperidine Benzodioxo Carbamate Trifluoro
JW480 Arylacetamide_deacetylase Carbamate Naphthalen
AS115 Arylacetamide_deacetylase Carbamate
WWL222 AlphaBeta_hydrolase pNP Carbamate
WWL50 Carb_B_Chordata Carbamate
WWL229 Carb_B_Chordata pNP Carbamate Piperidine
WWL113 ABHD6-Lip Carb_B_Chordata Carbamate Benzoate
WWL123 ABHD6-Lip Carbamate Biphenyl
WWL70 ABHD6-Lip Carb_B_Chordata Carbamate Biphenyl
Methiocarb ACHE BCHE Carb_B_Arthropoda Carbamate Insecticide Sulfur Compound
Croneton ACHE BCHE Carbamate Insecticide Sulfur Compound
Ladostigil ACHE BCHE Monoamine-oxidase-inhibitor Multitarget Carbamate Drug Inden
P-10358 ACHE BCHE Carbamate Indole Pyridine
Cymserine BCHE Derivative of physostigmine-eserine Carbamate Indole
Dihydrobenzodioxepine-cymeserine BCHE Derivative of physostigmine-eserine Carbamate
Tetrahydrofurobenzofuran-cymserine ACHE Derivative of physostigmine-eserine Carbamate Benzofuran
(-)-phenethylcymserine Carb_B_Chordata BCHE ACHE Derivative of physostigmine-eserine Carbamate
Cymyl-carbamate-physovenol ACHE Derivative of physostigmine-eserine Carbamate
N1-Phenethylnorcymserine BCHE Derivative of physostigmine-eserine Carbamate Indole
Bisnorcymserine BCHE ACHE Carbamate Indole Derivative of physostigmine-eserine
Physovenine ACHE Carbamate Natural Indole Derivative of physostigmine-eserine
Ganstigmine ACHE Derivative of physostigmine-eserine Carbamate Indole
Isoprocarb ACHE Insecticide Carbamate
Fenobucarb ACHE Insecticide Carbamate
Aldoxycarb ACHE Insecticide Carbamate Sulfur Compound
Alanycarb ACHE Insecticide Carbamate Sulfur Compound Propionate
Benfuracarb ACHE Insecticide Carbamate Sulfur Compound Benzofuran Propionate
Butoxycarboxim ACHE Insecticide Carbamate Sulfur Compound
Butocarboxim ACHE Insecticide Carbamate Sulfur Compound
Aldicarb ACHE Insecticide Carbamate Sulfur Compound
Aminocarb ACHE Insecticide Carbamate
Pyridophen-10 ACHE Muscarinic antagonist Propionate Carbamate Pro-Drug Multitarget Not A\/B H target PET probe
Dimethylhydroxycarbaphen BCHE Muscarinic antagonist Propionate Carbamate Pro-Drug Multitarget Not A\/B H target
Terbutaline-monocarbamate BCHE Derivative of Bambuterol Carbamate Drug tert-Butyl Not A\/B H target Pro-Drug
MTR-3 BCHE Derivative of Bambuterol Derivative of Rivastigmine Carbamate tert-Butyl
MTR-1 BCHE Derivative of Bambuterol Derivative of Rivastigmine Carbamate tert-Butyl
Biscarbamate-Cpd16 BCHE Derivative of Bambuterol Carbamate Piperidine
Bambuterol BCHE Derivative of Bambuterol Carbamate Drug tert-Butyl Not A\/B H target Pro-Drug
Banol ACHE Carbamate
Barban ACHE Carbamate Herbicide
Bendiocarb ACHE Insecticide Carbamate Benzodioxo
Benomyl ACHE Carbamate Fungicide Imidazole Benzimidazole
Bufencarb ACHE Carbamate Insecticide
Carbachol ACHE BCHE Not A\/B H target Carbamate Trimethylammonium Analogue of substrate Drug Muscarinic agonist Nicotinic agonist
Carbaryl ACHE Insecticide Carbamate
Biscarbofuran ACHE Insecticide Carbamate Sulfur Compound Benzofuran
Carbofuran ACHE Insecticide Carbamate Benzofuran
Carbosulfan ACHE Carbamate Benzofuran Insecticide Sulfur Compound
Nu-1250 ACHE Carbamate Trimethylammonium
Nu-1197 ACHE Carbamate Trimethylammonium
Cosban ACHE Insecticide Carbamate
Formetanate ACHE Insecticide Carbamate
Furathiocarb ACHE Insecticide Carbamate Sulfur Compound Benzofuran
Mecarbam ACHE Insecticide Organophosphate Carbamate Sulfur Compound
Metolcarb ACHE Insecticide Carbamate
Dioxacarb ACHE Insecticide Carbamate
Miotine ACHE Carbamate Derivative of Rivastigmine
Rivastigmine ACHE Derivative of Rivastigmine Carbamate Drug
EPTC ACHE Carbamate Herbicide Sulfur Compound
Fenoxycarb ACHE Insecticide Carbamate
Geneserine ACHE BCHE Natural Indole Carbamate Derivative of physostigmine-eserine
Heptylphysostigmine ACHE Derivative of physostigmine-eserine Carbamate Indole
Irinotecan Carboxylesterase Carb_B_Chordata Carb_B_Bacteria Carbamate Drug Derivative of Irinotecan Not A\/B H target
Methomyl ACHE Insecticide Carbamate Sulfur Compound
MF217 ACHE Derivative of physostigmine-eserine Carbamate Morpholine Indole
MF268 ACHE Derivative of physostigmine-eserine Carbamate Morpholine Indole
N-Methyl-7-dimethylcarbamoxyquinolinium ACHE BCHE Carbamate Quinoline
Neostigmine~Prostigmine ACHE BCHE Carbamate Trimethylammonium
Oxamyl BCHE ACHE Carbamate Sulfur Compound
Phenmedipham ACHE BCHE Carbamate Herbicide Not A\/B H target FAAH inhibitor
Posiphen ACHE Derivative of physostigmine-eserine Carbamate Drug Indole
Phenserine ACHE Derivative of physostigmine-eserine Carbamate Drug Indole
Physostigmine-methiodide ACHE Derivative of physostigmine-eserine Natural_modified Carbamate Indole
Physostigmine~Eserine ACHE BCHE Arylacetamide_deacetylase Derivative of physostigmine-eserine Natural Carbamate Drug Indole
Fmoc-Lys(Boc)-trimethylammonium-5e BCHE Fluoren Carbamate Trimethylammonium
Pirimicarb ACHE Carbamate Insecticide Pyrimidine
Triallate Carbamate Herbicide Sulfur Compound Not A\/B H target
Phenyl-benzyl-carbamate Carbamate NTE inhibitor Not A\/B H target
Promecarb ACHE Carbamate Insecticide
Propoxur ACHE BCHE Carbamate Insecticide
Distigmine BCHE Carbamate Drug Pyridine
Pyridostigmine BCHE ACHE Carbamate Drug Pyridine
Ro-2-0683 BCHE Trimethylammonium Carbamate
Quilostigmine ACHE Derivative of physostigmine-eserine Carbamate Isoquinoline Indole
Tolserine ACHE BCHE Derivative of physostigmine-eserine Carbamate Indole NTE inhibitor Not A\/B H target
Zectran ACHE Carbamate Insecticide
Isosorbide-2-benzylcarbamate-5-benzyl-ether BCHE Isosorbide Carbamate
Isosorbide-2-benzylcarbamate-5-benzoate BCHE Isosorbide Carbamate Benzoate
Isosorbide-2-benzylcarbamate-5-salicylate BCHE Isosorbide Salicylic Carbamate Benzoate
URB597 Monoglyceridelipase_lysophospholip Carbamate Biphenyl FAAH inhibitor Multitarget