Fluorobenzyl-nitro-oxoindolin-ylidene-methyl-phenyl-imidazolium
IC50 0.17 (nM) eleel AChE
General
Chemical_Nomenclature : 3-(3-fluorobenzyl)-1-(4-((5-nitro-2-oxoindolin-3-ylidene)methyl)phenyl)-1H-imidazol-3-ium bromide
Canonical SMILES : C1(=CC=C2C(=C1)C(C(N2)=O)=CC3=CC=C(C=C3)[N]4C=[N ](C=C4)CC5=CC(=CC=C5)F)[N+](=O)[O-].[Br-]
InChI : InChI=1S\/C25H17FN4O3.BrH\/c26-19-3-1-2-18(12-19)15-28-10-11-29(16-28)20-6-4-17(5-7-20)13-23-22-14-21(30(32)33)8-9-24(22)27-25(23)31\;\/h1-14,16H,15H2\;1H\/b23-13-\;
InChIKey : IOPPNTPQQZOYRM-OWGUYUHOSA-N
Other name(s) : Compound 32 || O=C1NC2=CC=C([N+]([O-])=O)C=C2\/C1=C\/C3=CC=C(N4C=[N+](CC5=CC=CC(F)=C5)C=C4)C=C3
Target
Families : Fluorobenzyl-nitro-oxoindolin-ylidene-methyl-phenyl-imidazolium ligand of proteins in family
ACHE
References (3)
| Title : Novel imidazolium salts bearing 2-oxindoles scaffold as potent acetylcholinesterase inhibitors for Alzheimer's disease: Design, synthesis, in vitro and in silico studies - Tien_2026_Bioorg.Med.Chem.Lett_134_130560 |
| Author(s) : Tien LQ , Phung HTT , Do HH , Khac TN , Minh PTN , Linh VNH , Thang NQ , Wang S , Tran PT |
| Ref : Bioorganic & Medicinal Chemistry Lett , 134 :130560 , 2026 |
| Abstract : |
| PubMedSearch : Tien_2026_Bioorg.Med.Chem.Lett_134_130560 |
| PubMedID: 41580137 |
| Title : Novel imidazolium salts bearing 2-oxindoles scaffold as potent acetylcholinesterase inhibitors for Alzheimer's disease: Design, synthesis, in vitro and in silico studies - Tien_2026_Bioorg.Med.Chem.Lett_134_130560 |
| Author(s) : Tien LQ , Phung HTT , Do HH , Khac TN , Minh PTN , Linh VNH , Thang NQ , Wang S , Tran PT |
| Ref : Bioorganic & Medicinal Chemistry Lett , 134 :130560 , 2026 |
| Abstract : |
| PubMedSearch : Tien_2026_Bioorg.Med.Chem.Lett_134_130560 |
| PubMedID: 41580137 |
| Title : Novel imidazolium salts bearing 2-oxindoles scaffold as potent acetylcholinesterase inhibitors for Alzheimer's disease: Design, synthesis, in vitro and in silico studies - Tien_2026_Bioorg.Med.Chem.Lett_134_130560 |
| Author(s) : Tien LQ , Phung HTT , Do HH , Khac TN , Minh PTN , Linh VNH , Thang NQ , Wang S , Tran PT |
| Ref : Bioorganic & Medicinal Chemistry Lett , 134 :130560 , 2026 |
| Abstract : |
| PubMedSearch : Tien_2026_Bioorg.Med.Chem.Lett_134_130560 |
| PubMedID: 41580137 |