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Indole

General

Fusion of benzene and pyrazole. Building block for many inhibitors of enzymes. Indole has only one nitrogen atom in position 1 of the pyrazol. Indazol is an analog with nitrogen atoms in position 1 and 2. Benzimidazole, an analog with the nitrogen atoms in positions 1 and 3.
Inhibitor Main targeted enzyme families Type Structure
Isatin-1,3,5-triazine-benzylamine ACHE Multitarget Triazine anti-Abeta-aggregation Indole
KK181-N1 RsbQ-like Urea derivative Strigolactone receptors ligand Triazol Indole
WXR BCHE Cycloheptyl Indole
WXN BCHE Cycloheptyl Indole
RIV-IND-5b2 ACHE Monoamine-oxidase-inhibitor Multitarget Derivative of Rivastigmine Indole anti-Abeta-aggregation Antioxidant
SCHEMBL22491361 Monoglyceridelipase_lysophospholip Benzoxazine Piperidine Indole
Contilistat Multitarget Histamine-Receptor3-H3-Antagonist Monoamine-oxidase-inhibitor Piperidine Indole HDAC inhibitor prop-2-yn-1-yl
JNJ-42226314 Monoglyceridelipase_lysophospholip Indole Thiazole Azetidin Piperazine Sulfur Compound
X20419 Thioesterase Piperazine Piperidine Pyrimidine Carboxamide Indole
6-(2-phenylethyl)-THAI-12b BCHE Indole Azepane
6-(4-4-phenethylpiperazin-1-yl)heptyl-THAI-14d BCHE Indole Azepane Piperazine Multitarget Alkyl linked bis-ligand anti-Abeta-aggregation
Diethoxyphosphoryloxy-oleanolic-acid BCHE Indole Natural_modified
Tabersonine Plant_carboxylesterase Indole Alkaloid Natural
Catharanthine Plant_carboxylesterase Indole Alkaloid Natural
Chlorophenyl-methylsulfonyl-indol-acryloyl-phenyl-acetamide-cpd5b BCHE ACHE Multitarget Indole Carboxamide Sulfur Compound Sulfonamide
Benzylpiperidin-methylsulfonyl-indol-acryloyl-phenyl-acetamide-cpd6b BCHE ACHE Multitarget Indole Carboxamide Piperidine Derivative of Donepezil Sulfur Compound
Dimethoxy-phenyl-pyrazino-indol-cpd5i ACHE Multitarget Indole Antioxidant
Benzylpiperidin-oxoindolin-acetamide-Cpd23 ACHE Derivative of Donepezil Piperidine Indole
Indole-piperidine-amide-cpd23a ACHE Multitarget Indole Carboxamide Derivative of Donepezil BACE1-inhibitor Piperidine
3-(Dimethylamino)-N-propanamide-Tryptanthrin ACHE Derivative of Deoxyvasicinone Quinazoline Indole
M-18C Monoglyceridelipase_lysophospholip Carboxamide Piperidine Indole
tacrine-isatin-Cpd7k ACHE anti-Abeta-aggregation Derivative of Tacrine Multitarget Alkyl linked bis-ligand Indole
tacrine-isatin-Cpd7d BCHE anti-Abeta-aggregation Derivative of Tacrine Multitarget Alkyl linked bis-ligand Indole
Chloroalkane-Cyanine3-fluorophore Haloalkane_dehalogenase-HLD2 Indole HaloTag-ligand
Adamantyl-urea-Cpd28 Epoxide_hydrolase Adamantyl Urea derivative Indole
Indol-thioxotetrahydropyrimidine-Cpd7 BCHE Sulfur Compound Indole Pyrimidine
Indol-thioxotetrahydropyrimidine-Cpd5 ACHE Sulfur Compound Indole Pyrimidine
Melatonin-alkylbenzylamine-Cpd5 BCHE Antioxidant Derivative of Tryptamine Indole Multitarget Alkyl linked bis-ligand
1-Dodecylindoline-2,3-dione Carb_B_Chordata Indole
SCHEMBL1532301 ACHE Indole Isoindole Acridine Alkyl linked bis-ligand Derivative of Tacrine Derivative of Donepezil
ZINC59501712 ACHE Sulfur Compound Indole Sulfonamide Phthalimido Benzenesulfonamide
ARUK3004048 Pectinacetylesterase-Notum Fragment inhibitor of Notum Indole
Indol-carbodithioate-azepane Lipase_3 Indole Azepane Sulfur Compound
C0I-7QHD BCHE Acridine Alkyl linked bis-ligand Derivative of Tacrine Carboxamide Derivative of Donepezil Indole Piperidine
Dihydroindole-thiourea-73 Epoxide_hydrolase Indole Urea derivative Multitarget 5-Lipoxygenase inhibitor Sulfur Compound
Allo-Ile-isoindoline DPP4N_Peptidase_S9 Isoindole
ZTL-11 ACHE GSK-3 kinase inhibitor Carboxamide Multitarget Triazol Indole Cyclopropyl beta-carboline
ZLWH-23 ACHE Piperidine GSK-3 kinase inhibitor Carboxamide Multitarget Indole Cyclopropyl beta-carboline
Lys-phospho-isoindoline DPP4N_Peptidase_S9 Acetanilide Peptide Indole Organophosphate
ARUK3004903 Pectinacetylesterase-Notum Fragment inhibitor of Notum Indole
ARUK3004308 Pectinacetylesterase-Notum Fragment inhibitor of Notum Indole
ARUK3004558 Pectinacetylesterase-Notum Fragment inhibitor of Notum Indole
ARUK3004470 Pectinacetylesterase-Notum Fragment inhibitor of Notum Indole
ARUK3004552 Pectinacetylesterase-Notum Fragment inhibitor of Notum Indole
ARUK3004556 Pectinacetylesterase-Notum Fragment inhibitor of Notum Indole
ARUK3005522 Pectinacetylesterase-Notum Fragment inhibitor of Notum Indole
ARUK3005518 Pectinacetylesterase-Notum Fragment inhibitor of Notum Indole
ARUK3004876 Pectinacetylesterase-Notum Fragment inhibitor of Notum Indole Trifluoro
ARUK3004877 Pectinacetylesterase-Notum Fragment inhibitor of Notum Indole
ARUK3006560 Pectinacetylesterase-Notum Fragment inhibitor of Notum Indole Trifluoro
ARUK3006561 Pectinacetylesterase-Notum Fragment inhibitor of Notum Indole Trifluoro
ARUK3006562 Pectinacetylesterase-Notum Fragment inhibitor of Notum Indole Trifluoro
ICeD-2 DPP4N_Peptidase_S9 Pyrrolidine Indole
Cpd-6-8AI7 BCHE Carbamate Indole Cycloheptyl Derivative of Tryptophan
Cpd-17-Cycloheptyl-Indole-undecyl-carbamate ACHE BCHE Carbamate Indole Cycloheptyl Derivative of Tryptophan Alkyne
Isatin-thiosemicarbazone-cpd13 ACHE BCHE Urea derivative Indole Sulfur Compound
6H6-Heptyl-Carbamate BCHE Carbamate Derivative of Tryptamine Indole
H327 BCHE Carbamate Derivative of Tryptamine Indole
BChE-IN-3 BCHE Derivative of Tryptophan Indole Carbamate Cycloheptyl Derivative of Tryptamine
CHEMBL57478 Pectinacetylesterase-Notum Fragment inhibitor of Notum Piperidine Indole
IA4-7BO3 BCHE Derivative of Tryptophan Indole Cycloheptyl
A87-7BO4 BCHE Derivative of Tryptophan Indole Cycloheptyl
TRaQ-G-ILQ Haloalkane_dehalogenase-HLD2 HaloTag-ligand Indole Benzosilin
FL217 Epoxide_hydrolase Multitarget PPARgamma ligand Cyclopropyl Sulfur Compound Sulfonamide Indole
ZYH-deriv-F Monoglyceridelipase_lysophospholip Azetidin Piperazine Carboxamide Pyrimidine PET probe Indole
Cpd14-BChEin-5-HT6 BCHE Multitarget 5-HT-receptor-ligand Sulfur Compound Indole Alkyl linked bis-ligand
Cpd17-Tacrine-5-HT6 ACHE BCHE Acridine Derivative of Tacrine Multitarget 5-HT-receptor-ligand Sulfur Compound Sulfonamide Indole Alkyl linked bis-ligand anti-Abeta-aggregation
Cpd54-BChEin-5-HT6 BCHE Multitarget 5-HT-receptor-ligand Sulfur Compound Sulfonamide Indole Alkyl linked bis-ligand tert-Butyloxycarbonyl tert-Butyl
Cpd70-BChEin-5-HT6 BCHE Multitarget 5-HT-receptor-ligand Indole Alkyl linked bis-ligand
Cpd27-BChEin-5-HT6 BCHE Multitarget 5-HT-receptor-ligand Sulfur Compound Sulfonamide Indole Alkyl linked bis-ligand
Cpd35-Rivastigmine-5-HT6 BCHE Derivative of Rivastigmine Multitarget 5-HT-receptor-ligand Sulfur Compound Sulfonamide Indole Carbamate Alkyl linked bis-ligand anti-Abeta-aggregation
Hypaphorine ACHE Not AlphaBeta Hydrolase target Natural Derivative of Tryptophan Indole Propionate
Cpd37-Fluoroindol-carbamate Monoglyceridelipase_lysophospholip Multitarget Carbamate Indole FAAH inhibitor Alkyl linked bis-ligand
Tetracyclic-carbamate-melatonine-3c BCHE Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline Derivative of Tryptamine Indole Alkyl linked bis-ligand
Harmine Natural Alkaloid Indole beta-carboline Not AlphaBeta Hydrolase target
6QAD-HUZ BCHE Derivative of Tryptophan Indole
6XTA-cpd18 BCHE Derivative of Tryptophan Indole Azepane
6QAE-HUK BCHE Derivative of Tryptophan Indole
6QAC-HUT BCHE Derivative of Tryptophan Indole
6QAB-HUQ BCHE Derivative of Tryptophan Indole
6QAA-HUN BCHE Derivative of Tryptophan Indole
Tryptamine ACHE Derivative of Tryptamine Indole Natural
N-[2-(5-fluoro-1H-indol-3-yl)ethyl]acetamide Pectinacetylesterase-Notum Derivative of Tryptamine Indole Not AlphaBeta Hydrolase target
N-acetylserotonin Pectinacetylesterase-Notum Derivative of Tryptamine Indole Not AlphaBeta Hydrolase target Natural
Melatonin Pectinacetylesterase-Notum Derivative of Tryptamine Indole Not AlphaBeta Hydrolase target Natural Antioxidant
Debromoflustramine-B BCHE Natural Pyrrolidine Indole Derivative of physostigmine-eserine
Methylene-blue-carboline-2 ACHE BCHE Cholinesterase Dye Multitarget Indole Phenothiazine beta-carboline Sulfur Compound
6H12-(R)2 ACHE Derivative of Tacrine Derivative of Valmerin Urea derivative GSK-3 kinase inhibitor Multitarget Isoindole Indole Triazol
6H13-(R)3 ACHE Derivative of Tacrine Derivative of Valmerin Urea derivative GSK-3 kinase inhibitor Multitarget Isoindole Indole Triazol
6H14-(S)6 ACHE Derivative of Tacrine Derivative of Valmerin Urea derivative GSK-3 kinase inhibitor Multitarget Isoindole Indole Triazol
KK023-N1 RsbQ-like Urea derivative Strigolactone receptors ligand Triazol Indole
KK023-N2 RsbQ-like Urea derivative Strigolactone receptors ligand Triazol Indole
KK094 RsbQ-like Urea derivative Strigolactone receptors ligand Triazol Indole
Sigma1R-ACHE-6a ACHE Multitarget 5-HT-receptor-ligand Piperidine Sigma1R Indole Derivative of Donepezil
Sigma1R-ACHE-6b ACHE Multitarget 5-HT-receptor-ligand Piperidine Sigma1R Indole Derivative of Donepezil
ZINC12863377 Monoglyceridelipase_lysophospholip Pyrrolidine Indole Carboxamide
Chlorotacrine-tryptophan-hybrid ACHE BCHE Derivative of Tacrine Multitarget Indole anti-Abeta-aggregation Alkyl linked bis-ligand
1-methylindol-3-one ACHE Indole
R-Pro-(decarboxy-Pro)-X99 S9N_PPCE_Peptidase_S9 Pyrrolidine Isoindole Indole
CHEMBL4293015 BCHE Indole Piperidine Derivative of Donepezil Alkyl linked bis-ligand
NP61 BCHE ACHE Indole Derivative of Tacrine Alkyl linked bis-ligand
Benzyl-2-triazole-linked-tryptamine-paeonol-Cpd896 BCHE Triazol Trifluoro Derivative of Tryptamine Indole
Contilisant ACHE BCHE Multitarget Histamine-Receptor3-H3-Antagonist Monoamine-oxidase-inhibitor Piperidine Indole prop-2-yn-1-yl
ASS234 ACHE Multitarget Monoamine-oxidase-inhibitor Alkyl linked bis-ligand Piperidine Indole
Donepezil-Melatonin-4u ACHE Derivative of Donepezil Derivative of Tryptamine Indole Alkyl linked bis-ligand Multitarget Antioxidant
Tacrine-Melatonin-Feruloyl-5c BCHE Derivative of Tacrine Derivative of Tryptamine Indole Multitarget Feruloyl Acrylate Antioxidant Hydroxycinnamic-ester Alkyl linked bis-ligand
Nijmegen-1 RsbQ-like Cotylimide Strigolactone receptors ligand Isoindole Indole Butenolide Phthalimido
ARUK3003718 Pectinacetylesterase-Notum Indole Oxobutanoate
ARUK3003907 Pectinacetylesterase-Notum Indole Oxobutanoate
ARUK3003910 Pectinacetylesterase-Notum Indole Oxobutanoate
ARUK3002704 Pectinacetylesterase-Notum Indole Oxobutanoate
ARUK3003906 Pectinacetylesterase-Notum Indole Oxobutanoate
CHEMBL1086968 S9N_PPCE_Peptidase_S9 Peptide Thiazolidine Cyclopropyl Indole Sulfur Compound
isoquinolinederivative18 DPP4N_Peptidase_S9 Piperazine Isoindole Indole
1G244 DPP4N_Peptidase_S9 Piperazine Isoindole Indole
Indolesufonamide1 DPP4N_Peptidase_S9 Sulfur Compound Indole Sulfonamide
Indol-adamantyl-carbamate-Cpd42 DPP4N_Peptidase_S9 Gliptin Adamantyl Carbamate Indole
Indol-adamantyl-carbamate-Nitrobenzooxadiazol-Cpd20 DPP4N_Peptidase_S9 Gliptin Adamantyl Carbamate Indole Oxadiazol NBD-nitro-benzoxadiazol-fluorescent Benzoxadiazole
CHEMBL3125351 Cholesterol_esterase Quinoline Indole
CHEMBL3125346 Cholesterol_esterase Quinoline Indole
Bis-Noreseroline ACHE Leaving group Indole Derivative of physostigmine-eserine
Psilocybin ACHE BCHE Organophosphate Natural Alkaloid Indole
P-10358 ACHE BCHE Carbamate Indole Pyridine
Phthalimido-Galanthaminium-4d ACHE Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Isoindole Phthalimido Benzazepin Azepane
Phthalimido-Galanthaminium-8d ACHE Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Isoindole Indole Phthalimido Benzazepin Azepane
Cymserine BCHE Derivative of physostigmine-eserine Carbamate Indole
N1-Phenethylnorcymserine BCHE Derivative of physostigmine-eserine Carbamate Indole
Bisnorcymserine BCHE ACHE Carbamate Indole Derivative of physostigmine-eserine
Gramine ACHE BCHE Alkaloid Natural Not AlphaBeta Hydrolase target Indole
Physovenine ACHE Carbamate Natural Indole Derivative of physostigmine-eserine
Ganstigmine ACHE Derivative of physostigmine-eserine Carbamate Indole
5-hydroxy-tryptamine ACHE BCHE Derivative of Tryptamine Indole Not AlphaBeta Hydrolase target Natural 5-HT-receptor-ligand
Dehydroevodiamine ACHE Natural Pyridine Indole beta-carboline Natural_modified Derivative of Evodiamine
Dialifor-oxon ACHE Organophosphate Insecticide Isoindole Indole Sulfur Compound
Dialifor ACHE Organophosphate Insecticide Isoindole Indole Sulfur Compound
Eseroline ACHE Derivative of physostigmine-eserine Indole
Geneserine ACHE BCHE Natural Indole Carbamate Derivative of physostigmine-eserine
Geneseroline Natural Indole Derivative of physostigmine-eserine Leaving group
Heptylphysostigmine ACHE Derivative of physostigmine-eserine Carbamate Indole
PIMP ACHE Organophosphate Surrogate OP Nerve Agent G-series Derivative of Sarin Phthalimido Isoindole
MF217 ACHE Derivative of physostigmine-eserine Carbamate Morpholine Indole
MF268 ACHE Derivative of physostigmine-eserine Carbamate Morpholine Indole
Posiphen ACHE Derivative of physostigmine-eserine Carbamate Drug Indole
Phenserine ACHE Derivative of physostigmine-eserine Carbamate Drug Indole
Phosmet ACHE Organophosphate Insecticide Sulfur Compound Organothiophosphate Isoindole Indole
Phosmetoxon ACHE Organophosphate Insecticide Sulfur Compound Organothiophosphate Isoindole Indole Phthalimido
Physostigmine-methiodide ACHE Derivative of physostigmine-eserine Natural_modified Carbamate Indole
Physostigmine~Eserine ACHE BCHE Arylacetamide_deacetylase Derivative of physostigmine-eserine Natural Carbamate Drug Indole
Ethylpiperidinyl-ethyl-indole-Cpd19 BCHE Indole Piperidine Natural
Gamma-carboline-phenothiazine-Cpd7b BCHE beta-carboline Phenothiazine Indole NMDA-Ligand Multitarget
Gamma-carboline-nonyl-bivalent BCHE ACHE beta-carboline Indole NMDA-Ligand Multitarget Alkyl linked bis-ligand
Quilostigmine ACHE Derivative of physostigmine-eserine Carbamate Isoquinoline Indole
Tolserine ACHE BCHE Derivative of physostigmine-eserine Carbamate Indole NTE inhibitor Not AlphaBeta Hydrolase target