GSK-264220A
Selective sulfonylfuran urea endothelial lipase inhibitors (human-LIPG)
General
Type : Urea derivative, Sulfur Compound, Sulfonamide
Chemical_Nomenclature : 1-(2-methyl-5-piperidin-1-ylsulfonylfuran-3-yl)-3-phenylurea
Canonical SMILES : CC1=C(C=C(O1)S(=O)(=O)N2CCCCC2)NC(=O)NC3=CC=CC=C3
InChI : InChI=1S\/C17H21N3O4S\/c1-13-15(19-17(21)18-14-8-4-2-5-9-14)12-16(24-13)25(22,23)20-10-6-3-7-11-20\/h2,4-5,8-9,12H,3,6-7,10-11H2,1H3,(H2,18,19,21)
InChIKey : LVOVQRPAMXCXTM-UHFFFAOYSA-N
Other name(s) : GSK 264220A || CHEMBL513349 || 3-[2-methyl-5-(piperidine-1-sulfonyl)furan-3-yl]-1-phenylurea || ZINC04324633 || AC1MDFFU
MW : 363.43
Formula : C17H21N3O4S
CAS_number : 685506-42-7
PubChem : 2810413
UniChem : LVOVQRPAMXCXTM-UHFFFAOYSA-N
IUPHAR : 6697
Target
Families : GSK-264220A ligand of proteins in family
Lipoprotein_Lipase
Protein :
human-LIPG
References (1)
| Title : Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors - Goodman_2009_Bioorg.Med.Chem.Lett_19_27 |
| Author(s) : Goodman KB , Bury MJ , Cheung M , Cichy-Knight MA , Dowdell SE , Dunn AK , Lee D , Lieby JA , Moore ML , Scherzer DA , Sha D , Suarez DP , Murphy DJ , Harpel MR , Manas ES , McNulty DE , Annan RS , Matico RE , Schwartz BK , Trill JJ , Sweitzer TD , Wang DY , Keller PM , Krawiec JA , Jaye MC |
| Ref : Bioorganic & Medicinal Chemistry Lett , 19 :27 , 2009 |
| Abstract : |
| PubMedSearch : Goodman_2009_Bioorg.Med.Chem.Lett_19_27 |
| PubMedID: 19058966 |
| Gene_locus related to this paper: human-LIPG |