Ginkgetin
human-CES2 IC50 20.08 +/- 1.69 nM. Ginkgetin is a biflavonoid that is the 7,4'-dimethyl ether derivative of amentoflavone. Isolated from Ginkgo biloba and Dioon, it exhibits anti-HSV-1, antineoplastic and inhibitory activities towards many enzymes
General
Type : Natural, Flavonoid, Chromen
Chemical_Nomenclature : 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxochromen-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)chromen-4-one
Canonical SMILES : COC1=C(C=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)OC)O)C4=C(C=C(C5=C4OC(=CC5=O)C6=CC=C(C=C6)O)O)O
InChI : InChI=1S\/C32H22O10\/c1-39-18-10-20(34)30-23(37)13-27(41-28(30)11-18)16-5-8-25(40-2)19(9-16)29-21(35)12-22(36)31-24(38)14-26(42-32(29)31)15-3-6-17(33)7-4-15\/h3-14,33-36H,1-2H3
InChIKey : AIFCFBUSLAEIBR-UHFFFAOYSA-N
Other name(s) : Amentoflavone 7,4'-dimethyl ether || 7,4'-Dimethylamentoflavone || UNII-HY5EZW8269 || CHEBI:5353 || SCHEMBL888410 || ZINC1531664
MW : 566.5
Formula : C32H22O10
CAS_number : 481-46-9
PubChem : 5271805
UniChem : AIFCFBUSLAEIBR-UHFFFAOYSA-N
Target
Families : Ginkgetin ligand of proteins in family
Carb_B_Chordata
Protein :
human-CES2
References (1)
| Title : Discovery and Characterization of the Biflavones From Ginkgo biloba as Highly Specific and Potent Inhibitors Against Human Carboxylesterase 2 - Song_2021_Front.Pharmacol_12_655659 |
| Author(s) : Song YQ , He RJ , Pu D , Guan XQ , Shi JH , Li YG , Hou J , Jia SN , Qin WW , Fang SQ , Ge GB |
| Ref : Front Pharmacol , 12 :655659 , 2021 |
| Abstract : |
| PubMedSearch : Song_2021_Front.Pharmacol_12_655659 |
| PubMedID: 34084136 |
| Gene_locus related to this paper: human-CES2 |