Inhibits tyrosinase. Has pleiotropic effects. Inhibitor of CES2A.High specificity over CES1A (>500-fold) and other serine hydrolases. Glabridin is cell permeable and low cytotoxicity. IC50 0.52 muM in cells
Chemical_Nomenclature : 4-[(3R)-8,8-dimethyl-3,4-dihydro-2H-pyrano[2,3-f]chromen-3-yl]benzene-1,3-diol
Canonical SMILES : CC1(C=CC2=C(O1)C=CC3=C2OCC(C3)C4=C(C=C(C=C4)O)O)C
InChI : InChI=1S\/C20H20O4\/c1-20(2)8-7-16-18(24-20)6-3-12-9-13(11-23-19(12)16)15-5-4-14(21)10-17(15)22\/h3-8,10,13,21-22H,9,11H2,1-2H3\/t13-\/m0\/s1
InChIKey : LBQIJVLKGVZRIW-ZDUSSCGKSA-N
Other name(s) : UNII-HOC5567T41, CHEBI:5369, HOC5567T41
MW : 324.37
Formula : C20H20O4
CAS_number : 59870-68-7
PubChem : 124052
UniChem : LBQIJVLKGVZRIW-ZDUSSCGKSA-N
Families : Glabridin ligand of proteins in family
Carb_B_Chordata
Protein :
human-CES2
mouse-Ces2a