HUP-55
IC50 (nM) 5.0 orcine PREP with Suc-Gly-Pro-AMC as the substrate
General
Type : Pyrrolidine, Cyanide, Oxazole
Chemical_Nomenclature : (2S)-1-[4-methyl-2-(3-phenylpropyl)-1,3-oxazol-5-yl]pyrrolidine-2-carbonitrile
Canonical SMILES : CC1=C(OC(=N1)CCCC2=CC=CC=C2)N3CCC[C@H]3C#N
InChI : InChI=1S\/C18H21N3O\/c1-14-18(21-12-6-10-16(21)13-19)22-17(20-14)11-5-9-15-7-3-2-4-8-15\/h2-4,7-8,16H,5-6,9-12H2,1H3\/t16-\/m0\/s1
InChIKey : FEEUIAMWBWZZNX-INIZCTEOSA-N
Other name(s) : HUP55 || orb1979990 || CHEMBL5424208 || SCHEMBL26616532 || GLXC-27422 || HY-169831
MW : 295.4
Formula : C18H21N3O
CAS_number :
PubChem : 169259975
UniChem : FEEUIAMWBWZZNX-INIZCTEOSA-N
Target
Families : HUP-55 ligand of proteins in family
S9N_PPCE_Peptidase_S9
Protein :
pig-ppce
References (2)
| Title : Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on alpha-Synuclein Mouse Models of Parkinson's Disease - Kilpelainen_2023_J.Med.Chem_66_7475 |
| Author(s) : Kilpelainen TP , Patsi HT , Svarcbahs R , Julku UH , Etelainen TS , Cui H , Auno S , Sipari N , Norrbacka S , Leino TO , Jantti M , Myohanen TT , Wallen EAA |
| Ref : Journal of Medicinal Chemistry , 66 :7475 , 2023 |
| Abstract : |
| PubMedSearch : Kilpelainen_2023_J.Med.Chem_66_7475 |
| PubMedID: 37248563 |
| Gene_locus related to this paper: pig-ppce |
| Title : The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy - Kilpelainen_2020_Biomed.Pharmacother_128_110253 |
| Author(s) : Kilpelainen TP , Hellinen L , Vrijdag J , Yan X , Svarcbahs R , Vellonen KS , Lambeir AM , Huttunen H , Urtti A , Wallen EAA , Myohanen TT |
| Ref : Biomed Pharmacother , 128 :110253 , 2020 |
| Abstract : |
| PubMedSearch : Kilpelainen_2020_Biomed.Pharmacother_128_110253 |
| PubMedID: 32447211 |
| Gene_locus related to this paper: human-PREPL , pig-ppce |