Isoindolin-1,3-dione-acetohydrazide-cpd8a
IC50 = 0.11 +/- 0.05 micrM against AChE and IC50 = 30.2 +/- 2.8 microM against BChE
General
Type : Hydrazide, Indole, Isoindole
Chemical_Nomenclature : (benzyl(methyl)amino)-N-(2-(3-(1,3-dioxoisoindolin-2-yl)propoxy)benzylidene)acetohydrazide
Canonical SMILES : N4(CCCOC1=CC=CC=C1C=NNC(=O)CN(CC2=CC=CC=C2)C)C(C3=CC=CC=C3C4=O)=O
InChI : InChI=1S\/C28H28N4O4\/c1-31(19-21-10-3-2-4-11-21)20-26(33)30-29-18-22-12-5-8-15-25(22)36-17-9-16-32-27(34)23-13-6-7-14-24(23)28(32)35\/h2-8,10-15,18H,9,16-17,19-20H2,1H3,(H,30,33)
InChIKey : QGZRNUJDJGEUKO-UHFFFAOYSA-N
Other name(s) : Compound 8a
Target
Families : Isoindolin-1,3-dione-acetohydrazide-cpd8a ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Anticholinesterase activities of novel isoindolin-1,3-dione-based acetohydrazide derivatives: design, synthesis, biological evaluation, molecular dynamic study - Nazarian_2024_BMC.Chem_18_64 |
| Author(s) : Nazarian A , Abedinifar F , Hamedifar H , Hashempur MH , Mahdavi M , Sepehri N , Iraji A |
| Ref : BMC Chem , 18 :64 , 2024 |
| Abstract : |
| PubMedSearch : Nazarian_2024_BMC.Chem_18_64 |
| PubMedID: 38561813 |