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Isoindole

General

Fusion of benzene and pyrazole. Building block for many inhibitors of enzymes. Indole is an analog with only one nitrogen atom in position 1. Building block for many inhibitors of enzymes
Inhibitor Main targeted enzyme families Type Structure
Sigma1R-BCHE-Cpd7c BCHE Multitarget Sigma1R ligand Azetidin Carbamate Indole Isoindole
SCHEMBL30685148 DPP4N_Peptidase_S9 Indole Adamantyl Isoindole
t-TUCB-PROTAC-P3 Epoxide_hydrolase Urea derivative Multitarget FAAH inhibitor Triazol Trifluoro Piperidine Indole Isoindole PROTAC
t-TUCB-PROTAC-P4 Epoxide_hydrolase Urea derivative Triazol Trifluoro Piperidine Indole Piperazine Multitarget Isoindole FAAH inhibitor PROTAC
Isoindolin-1,3-dione-acetohydrazide-cpd8a ACHE Hydrazide Indole Isoindole
CHEMBL3402707 ACHE Isoindole Indole
Isoquinoline-derivative-Cpd21 DPP4N_Peptidase_S9 Piperidine Isoindole Indole
Bivalent-phthalimide-pyrazole-carbamate-cpd8a ACHE Carbamate Indole Isoindole Pyrazole Phthalimido
Tominostat DPP4N_Peptidase_S9 Indole Isoindole Piperazine
SCHEMBL4415503 ACHE Trifluoro Phthalimido Isoindole Indole
PROTAC-FL412 Epoxide_hydrolase Urea derivative Trifluoro PROTAC Multitarget Piperidine Isoindole Indole
PROTAC-JSF67 Epoxide_hydrolase PROTAC Multitarget Trifluoro Piperidine Indole Isoindole Triazol Sulfur Compound Sulfonamide Carboxamide
SCHEMBL16509423 DPP4N_Peptidase_S9 Pyrrolidine Cyanide Isoindole Indole
CHEMBL3817958 S9N_PPCE_Peptidase_S9 Isoindole Indole Pyrrolidine Cyanide
ALT-PG2 Epoxide_hydrolase Urea derivative Trifluoro PROTAC Piperidine Indole Isoindole Multitarget
SCHEMBL1532301 ACHE Indole Isoindole Acridine Alkyl linked bis-ligand Derivative of Tacrine Derivative of Donepezil Organochlorine
ZINC59501712 ACHE Sulfur Compound Indole Isoindole Sulfonamide Phthalimido Benzenesulfonamide
Indol-carbodithioate-azepane Lipase_3 Indole Isoindole Azepane Sulfur Compound
Allo-Ile-isoindoline DPP4N_Peptidase_S9 Isoindole Indole
Benzyl-piperidine-4-ethyl-phthalimide-6c ACHE Isoindole Piperidine Indole Benzylpiperidine Derivative of Donepezil
Lys-phospho-isoindoline DPP4N_Peptidase_S9 Acetanilide Peptide Indole Isoindole Organophosphate
ICeD-2 DPP4N_Peptidase_S9 Pyrrolidine Indole Isoindole
R-Pro-(decarboxy-Pro)-X99 S9N_PPCE_Peptidase_S9 Pyrrolidine Phthalimido Isoindole Indole
Nijmegen-1 RsbQ-like Cotylimide Strigolactone receptors ligand Isoindole Indole Butenolide Phthalimido
1G244 DPP4N_Peptidase_S9 Piperazine Isoindole Indole
Indol-adamantyl-carbamate-Cpd42 DPP4N_Peptidase_S9 Gliptin Adamantyl Carbamate Indole Isoindole
Phthalimido-Galanthaminium-4d ACHE Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Isoindole Indole Phthalimido Benzazepin Azepane
Phthalimido-Galanthaminium-8d ACHE Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Isoindole Indole Phthalimido Benzazepin Azepane
Dialifor-oxon ACHE Organophosphate Insecticide Phthalimido Isoindole Indole Sulfur Compound Organochlorine
Dialifor ACHE Organophosphate Insecticide Phthalimido Isoindole Indole Sulfur Compound Organochlorine
PIMP ACHE Organophosphate Surrogate OP Nerve Agent G-series Derivative of Sarin Phthalimido Isoindole Indole
Phosmet ACHE Organophosphate Insecticide Sulfur Compound Organothiophosphate Isoindole Indole
Phosmetoxon ACHE Organophosphate Insecticide Sulfur Compound Organothiophosphate Isoindole Indole Phthalimido
Sigma1R-BCHE-Cpd7c BCHE Multitarget Sigma1R ligand Azetidin Carbamate Indole Isoindole
SCHEMBL30685148 DPP4N_Peptidase_S9 Indole Adamantyl Isoindole
t-TUCB-PROTAC-P3 Epoxide_hydrolase Urea derivative Multitarget FAAH inhibitor Triazol Trifluoro Piperidine Indole Isoindole PROTAC
t-TUCB-PROTAC-P4 Epoxide_hydrolase Urea derivative Triazol Trifluoro Piperidine Indole Piperazine Multitarget Isoindole FAAH inhibitor PROTAC
Isoindolin-1,3-dione-acetohydrazide-cpd8a ACHE Hydrazide Indole Isoindole
CHEMBL3402707 ACHE Isoindole Indole
Isoquinoline-derivative-Cpd21 DPP4N_Peptidase_S9 Piperidine Isoindole Indole
Bivalent-phthalimide-pyrazole-carbamate-cpd8a ACHE Carbamate Indole Isoindole Pyrazole Phthalimido
Tominostat DPP4N_Peptidase_S9 Indole Isoindole Piperazine
SCHEMBL4415503 ACHE Trifluoro Phthalimido Isoindole Indole
PROTAC-FL412 Epoxide_hydrolase Urea derivative Trifluoro PROTAC Multitarget Piperidine Isoindole Indole
PROTAC-JSF67 Epoxide_hydrolase PROTAC Multitarget Trifluoro Piperidine Indole Isoindole Triazol Sulfur compound Sulfonamide Carboxamide
SCHEMBL16509423 DPP4N_Peptidase_S9 Pyrrolidine Cyanide Isoindole Indole
CHEMBL3817958 S9N_PPCE_Peptidase_S9 Isoindole Indole Pyrrolidine Cyanide
ALT-PG2 Epoxide_hydrolase Urea derivative Trifluoro PROTAC Piperidine Indole Isoindole Multitarget
SCHEMBL1532301 ACHE Indole Isoindole Acridine Alkyl linked bis-ligand Derivative of Tacrine Derivative of Donepezil Organochlorine
ZINC59501712 ACHE Sulfur compound Indole Isoindole Sulfonamide Phthalimido Benzenesulfonamide
Indol-carbodithioate-azepane Lipase_3 Indole Isoindole Azepane Sulfur compound
Allo-Ile-isoindoline DPP4N_Peptidase_S9 Isoindole Indole
Benzyl-piperidine-4-ethyl-phthalimide-6c ACHE Isoindole Piperidine Indole Benzylpiperidine Derivative of Donepezil
Lys-phospho-isoindoline DPP4N_Peptidase_S9 Acetanilide Peptide Indole Isoindole Organophosphate
ICeD-2 DPP4N_Peptidase_S9 Pyrrolidine Indole Isoindole
R-Pro-(decarboxy-Pro)-X99 S9N_PPCE_Peptidase_S9 Pyrrolidine Phthalimido Isoindole Indole
Nijmegen-1 RsbQ-like Cotylimide Strigolactone receptors ligand Isoindole Indole Butenolide Phthalimido
1G244 DPP4N_Peptidase_S9 Piperazine Isoindole Indole
Indol-adamantyl-carbamate-Cpd42 DPP4N_Peptidase_S9 Gliptin Adamantyl Carbamate Indole Isoindole
Phthalimido-Galanthaminium-4d ACHE Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Isoindole Indole Phthalimido Benzazepin Azepane
Phthalimido-Galanthaminium-8d ACHE Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Isoindole Indole Phthalimido Benzazepin Azepane
Dialifor-oxon ACHE Organophosphate Insecticide Phthalimido Isoindole Indole Sulfur compound Organochlorine
Dialifor ACHE Organophosphate Insecticide Phthalimido Isoindole Indole Sulfur compound Organochlorine
PIMP ACHE Organophosphate Surrogate OP Nerve Agent G-series Derivative of Sarin Phthalimido Isoindole Indole
Phosmet ACHE Organophosphate Insecticide Sulfur compound Organothiophosphate Isoindole Indole
Phosmetoxon ACHE Organophosphate Insecticide Sulfur compound Organothiophosphate Isoindole Indole Phthalimido
Sigma1R-BCHE-Cpd7c BCHE Multitarget Sigma1R ligand Azetidin Carbamate Indole Isoindole
SCHEMBL30685148 DPP4N_Peptidase_S9 Indole Adamantyl Isoindole
t-TUCB-PROTAC-P3 Epoxide_hydrolase Urea derivative Multitarget FAAH inhibitor Triazol Trifluoro Piperidine Indole Isoindole PROTAC
t-TUCB-PROTAC-P4 Epoxide_hydrolase Urea derivative Triazol Trifluoro Piperidine Indole Piperazine Multitarget Isoindole FAAH inhibitor PROTAC
Isoindolin-1,3-dione-acetohydrazide-cpd8a ACHE Hydrazide Indole Isoindole
CHEMBL3402707 ACHE Isoindole Indole
Isoquinoline-derivative-Cpd21 DPP4N_Peptidase_S9 Piperidine Isoindole Indole
Bivalent-phthalimide-pyrazole-carbamate-cpd8a ACHE Carbamate Indole Isoindole Pyrazole Phthalimido
Tominostat DPP4N_Peptidase_S9 Indole Isoindole Piperazine
SCHEMBL4415503 ACHE Trifluoro Phthalimido Isoindole Indole
PROTAC-FL412 Epoxide_hydrolase Urea derivative Trifluoro PROTAC Multitarget Piperidine Isoindole Indole
PROTAC-JSF67 Epoxide_hydrolase PROTAC Multitarget Trifluoro Piperidine Indole Isoindole Triazol Sulfur compound Sulfonamide Carboxamide
SCHEMBL16509423 DPP4N_Peptidase_S9 Pyrrolidine Cyanide Isoindole Indole
CHEMBL3817958 S9N_PPCE_Peptidase_S9 Isoindole Indole Pyrrolidine Cyanide
ALT-PG2 Epoxide_hydrolase Urea derivative Trifluoro PROTAC Piperidine Indole Isoindole Multitarget
SCHEMBL1532301 ACHE Indole Isoindole Acridine Alkyl linked bis-ligand Derivative of Tacrine Derivative of Donepezil Organochlorine
ZINC59501712 ACHE Sulfur compound Indole Isoindole Sulfonamide Phthalimido Benzenesulfonamide
Indol-carbodithioate-azepane Lipase_3 Indole Isoindole Azepane Sulfur compound
Allo-Ile-isoindoline DPP4N_Peptidase_S9 Isoindole Indole
Benzyl-piperidine-4-ethyl-phthalimide-6c ACHE Isoindole Piperidine Indole Benzylpiperidine Derivative of Donepezil
Lys-phospho-isoindoline DPP4N_Peptidase_S9 Acetanilide Peptide Indole Isoindole Organophosphate
ICeD-2 DPP4N_Peptidase_S9 Pyrrolidine Indole Isoindole
R-Pro-(decarboxy-Pro)-X99 S9N_PPCE_Peptidase_S9 Pyrrolidine Phthalimido Isoindole Indole
Nijmegen-1 RsbQ-like Cotylimide Strigolactone receptors ligand Isoindole Indole Butenolide Phthalimido
1G244 DPP4N_Peptidase_S9 Piperazine Isoindole Indole
Indol-adamantyl-carbamate-Cpd42 DPP4N_Peptidase_S9 Gliptin Adamantyl Carbamate Indole Isoindole
Phthalimido-Galanthaminium-4d ACHE Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Isoindole Indole Phthalimido Benzazepin Azepane
Phthalimido-Galanthaminium-8d ACHE Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Isoindole Indole Phthalimido Benzazepin Azepane
Dialifor-oxon ACHE Organophosphate Insecticide Phthalimido Isoindole Indole Sulfur compound Organochlorine
Dialifor ACHE Organophosphate Insecticide Phthalimido Isoindole Indole Sulfur compound Organochlorine
PIMP ACHE Organophosphate Surrogate OP Nerve Agent G-series Derivative of Sarin Phthalimido Isoindole Indole
Phosmet ACHE Organophosphate Insecticide Sulfur compound Organothiophosphate Isoindole Indole
Phosmetoxon ACHE Organophosphate Insecticide Sulfur compound Organothiophosphate Isoindole Indole Phthalimido