Methoxy-trifluoromethyl-phenyl-thiazol-hydrazineylidene-methyl-phenol-Cpdi
IC50 ACHE 0.028 +/- 0.001 microM
General
Type : Hydrazide, Hydrazinylidene, Trifluoro, Sulfur Compound, Thiazole
Chemical_Nomenclature : 2-Methoxy-5-[(2-{4-[4-(trifluoromethyl)phenyl]thiazol-2-yl}hydrazineylidene)methyl]phenol
Canonical SMILES : C1=C(C=C(C(=C1)OC)O)C=NNC2=NC(=CS2)C3=CC=C(C=C3)C(F)(F)F
InChI : InChI=1S\/C18H14F3N3O2S\/c1-26-16-7-2-11(8-15(16)25)9-22-24-17-23-14(10-27-17)12-3-5-13(6-4-12)18(19,20)21\/h2-10,25H,1H3,(H,23,24)
InChIKey : IVSTYWVJFNNSAO-UHFFFAOYSA-N
Other name(s) : Compound i
Target
Families : Methoxy-trifluoromethyl-phenyl-thiazol-hydrazineylidene-methyl-phenol-Cpdi ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Design, Synthesis, and Structure-Activity Relationships of Thiazole Analogs as Anticholinesterase Agents for Alzheimer's Disease - Saglik_2020_Molecules_25_4312 |
| Author(s) : Saglik BN , Osmaniye D , Acar Cevik U , Levent S , Kaya Cavusoglu B , Ozkay Y , Kaplancikli ZA |
| Ref : Molecules , 25 : , 2020 |
| Abstract : |
| PubMedSearch : Saglik_2020_Molecules_25_4312 |
| PubMedID: 32962239 |