NV-9
N/O-propargylated diarylpyrimidine NV-9 IC50 AChE 0.88 microM; IC50 MAO-A 9.31 microM; IC50 MAO-B 9.23 microM
General
Type : Multitarget, Propargyl, Monoamine-oxidase-inhibitor, Pyrimidine
Chemical_Nomenclature : 4-(3-nitrophenyl)-N-(prop-2-yn-1-yl)-6-(3,4,5-trimethoxyphenyl)pyrimidin-2-amine
Canonical SMILES : C1(=C(C(=CC(=C1)C2=NC(=NC(=C2)C3=CC(=CC=C3)[N+](=O)[O-])NCC#C)OC)OC)OC
InChI : InChI=1S\/C22H20N4O5\/c1-5-9-23-22-24-17(14-7-6-8-16(10-14)26(27)28)13-18(25-22)15-11-19(29-2)21(31-4)20(12-15)30-3\/h1,6-8,10-13H,9H2,2-4H3,(H,23,24,25)
InChIKey : PFYMQAHCZHVZGY-UHFFFAOYSA-N
Other name(s) :
Target
Families : NV-9 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Synthesis and biological evaluation of N\/O-propargylated diarylpyrimidines as dual inhibitors of acetylcholinesterase and monoamine oxidase - Kumar_2026_RSC.Adv_16_13369 |
| Author(s) : Kumar N , Jangid K , Kumar V , Dwivedi AR , Devi B , Arora T , Parkash J |
| Ref : RSC Adv , 16 :13369 , 2026 |
| Abstract : |
| PubMedSearch : Kumar_2026_RSC.Adv_16_13369 |
| PubMedID: 41815391 |