Naphthylethyl-propyl-triazol-thio-thiazol-ethanone
AChE IC50 25nM; IC50 BChE >600microM
General
Type : Sulfur Compound, Triazol, Thiazol, Naphthalen
Chemical_Nomenclature : 2-{5-[2-(naphthalen-1-yl)ethyl]-4-propyl-4H-1,2,4-triazol-3-ylthio}-1-(1,3-thiazol-2-yl)ethan-1-one
Canonical SMILES : N1=C([N](C(=N1)CCC2=C3C(=CC=C2)C=CC=C3)CCC)SCC(C4=NC=CS4)=O
InChI : InChI=1S\/C22H22N4OS2\/c1-2-13-26-20(11-10-17-8-5-7-16-6-3-4-9-18(16)17)24-25-22(26)29-15-19(27)21-23-12-14-28-21\/h3-9,12,14H,2,10-11,13,15H2,1H3
InChIKey : BJTALJJEOJTHKW-UHFFFAOYSA-N
Other name(s) : 2-{5-[2-(1-Naphthyl)ethyl]-4-propyl-4H-1,2,4-triazol-3-ylthio}-1-(1,3-thiazol-2-yl)-1-ethanone
Target
Families : Naphthylethyl-propyl-triazol-thio-thiazol-ethanone ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Synthesis and Pharmacological Evaluation of Novel 1,5-Disubstituted-3-amino-1,2,4-triazoles Designed as Multitarget Directed Ligands for Alzheimer's Disease Targets - Franco_2026_ACS.Omega_11_13184 |
| Author(s) : Franco DP , Caruso L , Grillo DCN , Nadur NF , de Azevedo LL , Pereira TM , da Silva MC , Lacerda RB , Pinheiro PSM , Riger CJ , Kummerle AE |
| Ref : ACS Omega , 11 :13184 , 2026 |
| Abstract : |
| PubMedSearch : Franco_2026_ACS.Omega_11_13184 |
| PubMedID: 41799150 |