For AChE Phenylacetone is a competitive inhibitor of the enzyme but not a transition state analog. Binding constant similar to the substrate phenyl acetate
Type : Ketone
Chemical_Nomenclature : 1-phenylpropan-2-one
Canonical SMILES : CC(=O)CC1=CC=CC=C1
InChI : InChI=1S\/C9H10O\/c1-8(10)7-9-5-3-2-4-6-9\/h2-6H,7H2,1H3
InChIKey : QCCDLTOVEPVEJK-UHFFFAOYSA-N
Other name(s) : 1-phenylpropan-2-one || 1-Phenyl-2-propanone || Benzyl methyl ketone || Benzyl-methyl-ketone || BMK
MW : 134.17
Formula : C9H10O
CAS_number : 103-79-7
PubChem : 7678
UniChem : QCCDLTOVEPVEJK-UHFFFAOYSA-N
Families : Phenylacetone ligand of proteins in family
Monoglyceridelipase_lysophospholip
ACHE
Structure :
6KHL
Protein :
cutac-e6dae5
eleel-ACHE
Title : The grease trap: Uncovering the mechanism of the hydrophobic lid in Cutibacterium acnes lipase - Kim_2020_J.Lipid.Res__ |
Author(s) : Kim HJ , Lee BJ , Kwon AR |
Ref : J Lipid Res , : , 2020 |
Abstract : |
PubMedSearch : Kim_2020_J.Lipid.Res__ |
PubMedID: 32165394 |
Gene_locus related to this paper: cutac-e6dae5 |
Title : The mode of binding of potential transition-state analogs to acetylcholinesterase - Dafforn_1977_Biochim.Biophys.Acta_484_375 |
Author(s) : Dafforn A , Anderson M , Ash D , Campagna J , Daniel E , Horwood R , Kerr P , Rych G , Zappitelli F |
Ref : Biochimica & Biophysica Acta , 484 :375 , 1977 |
Abstract : |
PubMedSearch : Dafforn_1977_Biochim.Biophys.Acta_484_375 |
PubMedID: 20963 |