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ketone

General

Ketone are compound with the structure RC(=O)R', where R and R' can be a variety of carbon-containing substituents. Building block for many inhibitors of enzymes
Inhibitor Main targeted enzyme families Type Structure
ZPCK Carboxypeptidase_S10 Benzyloxycarbonyl Carbamate Peptide ketone Carboxamide Halo ketone Organochlorine
ATFMK Monoglyceridelipase_lysophospholip ketone Trifluoro
AcACMK ACPH_Peptidase_S9 Peptide ketone Halo ketone Organochlorine
8-mercapto-1,1,1-tri-fluoro-2-octanone Juvenile_hormone_esterase Trifluoro Sulfur Compound Halo ketone
Phenylacetone Monoglyceridelipase_lysophospholip ACHE ketone
Tosyl-L-lysine-chloromethyl-ketone Carb_B_Bacteria BCHE S9N_PREPL_Peptidase_S9 ketone Sulfur Compound Sulfonamide Benzenesulfonamide Peptide Halo ketone Organochlorine
Difluoromethyl-ketone-BT7 ACHE ketone Pyrazole
1,3,4-oxadiazolyl-ketone-18h DPP4N_Peptidase_S9 Pyrrolidine ketone Oxadiazol tert-Butyl
Lilly-aryl-ketone DPP4N_Peptidase_S9 ketone
2-Tridecanone Hydroxynitrile_lyase Natural ketone
6AX1-cp3 Monoglyceridelipase_lysophospholip Halo ketone Trifluoro Carbamate Azetidin Oxadiazol
Acetone Hydroxynitrile_lyase ketone
Hexafluoracetone Hydroxynitrile_lyase Trifluoro Halo ketone
OTFP Juvenile_hormone_esterase Cutinase Trifluoro Halo ketone Sulfur Compound
DETFP Juvenile_hormone_esterase Carb_B_Chordata Carboxylesterase Trifluoro Sulfur Compound Halo ketone
OTFPdOHSO2 Juvenile_hormone_esterase Trifluoro Sulfur Compound Sulfonyl Halo ketone
Z-Gly-Gly-Phe-chloromethyl-ketone ACPH_Peptidase_S9 Benzyloxycarbonyl Carbamate Peptide ketone Carboxamide Halo ketone Organochlorine
PHK Proline_iminopeptidase Peptide Halo ketone Organochlorine
JW651 Monoglyceridelipase_lysophospholip Plasmodium_subtelomeric_PST-A Piperazine Halo ketone Carbamate Trifluoro Organochlorine
KML29 Monoglyceridelipase_lysophospholip Plasmodium_subtelomeric_PST-A Halo ketone Piperidine Benzodioxo Carbamate Trifluoro
Zifrosilone ACHE Halo ketone Transition state analogue Trifluoro
1-Chloro-3-phenoxy-2-propanone ACHE Halo ketone ketone Organochlorine Transition state analogue
1-phenoxypropanone ACHE ketone Transition state analogue
6-Dimethyl-3-difluoro-2-heptanone ACHE Halo ketone Transition state analogue Analogue of substrate
6-Methyl-2-heptanone ketone
Coumarinyl-ethyl-p-trifluoroacetamidophenylmethylphosphonate BCHE Trifluoro Organophosphate Halo ketone Coumarin Chromen
TBTFA ACHE BCHE Halo ketone Transition state analogue Trifluoro tert-Butyl
MBTFP Cutinase Juvenile_hormone_esterase Trifluoro Transition state analogue Halo ketone Sulfur Compound
TMTFA ACHE Trifluoro Trimethylammonium Ammonium Quaternary compound Transition state analogue Halo ketone
Trifluoro-6-dimethyl-2-heptanone BCHE ACHE Trifluoro Halo ketone
ZPCK Carboxypeptidase_S10 Benzyloxycarbonyl Carbamate Peptide ketone Carboxamide Halo ketone Organochlorine
ATFMK Monoglyceridelipase_lysophospholip ketone Trifluoro
AcACMK ACPH_Peptidase_S9 Peptide ketone Halo ketone Organochlorine
8-mercapto-1,1,1-tri-fluoro-2-octanone Juvenile_hormone_esterase Trifluoro Sulfur compound Halo ketone
Phenylacetone Monoglyceridelipase_lysophospholip ACHE ketone
Tosyl-L-lysine-chloromethyl-ketone Carb_B_Bacteria BCHE S9N_PREPL_Peptidase_S9 ketone Sulfur compound Sulfonamide Benzenesulfonamide Peptide Halo ketone Organochlorine
Difluoromethyl-ketone-BT7 ACHE ketone Pyrazole
1,3,4-oxadiazolyl-ketone-18h DPP4N_Peptidase_S9 Pyrrolidine ketone Oxadiazol tert-Butyl
Lilly-aryl-ketone DPP4N_Peptidase_S9 ketone
2-Tridecanone Hydroxynitrile_lyase Natural ketone
6AX1-cp3 Monoglyceridelipase_lysophospholip Halo ketone Trifluoro Carbamate Azetidin Oxadiazol
Acetone Hydroxynitrile_lyase ketone
Hexafluoracetone Hydroxynitrile_lyase Trifluoro Halo ketone
OTFP Juvenile_hormone_esterase Cutinase Trifluoro Halo ketone Sulfur compound
DETFP Juvenile_hormone_esterase Carb_B_Chordata Carboxylesterase Trifluoro Sulfur compound Halo ketone
OTFPdOHSO2 Juvenile_hormone_esterase Trifluoro Sulfur compound Sulfonyl Halo ketone
Z-Gly-Gly-Phe-chloromethyl-ketone ACPH_Peptidase_S9 Benzyloxycarbonyl Carbamate Peptide ketone Carboxamide Halo ketone Organochlorine
PHK Proline_iminopeptidase Peptide Halo ketone Organochlorine
JW651 Monoglyceridelipase_lysophospholip Plasmodium_subtelomeric_PST-A Piperazine Halo ketone Carbamate Trifluoro Organochlorine
KML29 Monoglyceridelipase_lysophospholip Plasmodium_subtelomeric_PST-A Halo ketone Piperidine Benzodioxo Carbamate Trifluoro
Zifrosilone ACHE Halo ketone Transition state analogue Trifluoro
1-Chloro-3-phenoxy-2-propanone ACHE Halo ketone ketone Organochlorine Transition state analogue
1-phenoxypropanone ACHE ketone Transition state analogue
6-Dimethyl-3-difluoro-2-heptanone ACHE Halo ketone Transition state analogue Analogue of substrate
6-Methyl-2-heptanone ketone
Coumarinyl-ethyl-p-trifluoroacetamidophenylmethylphosphonate BCHE Trifluoro Organophosphate Halo ketone Coumarin Chromen
TBTFA ACHE BCHE Halo ketone Transition state analogue Trifluoro tert-Butyl
MBTFP Cutinase Juvenile_hormone_esterase Trifluoro Transition state analogue Halo ketone Sulfur compound
TMTFA ACHE Trifluoro Trimethylammonium Ammonium Quaternary compound Transition state analogue Halo ketone
Trifluoro-6-dimethyl-2-heptanone BCHE ACHE Trifluoro Halo ketone
ZPCK Carboxypeptidase_S10 Benzyloxycarbonyl Carbamate Peptide ketone Carboxamide Halo ketone Organochlorine
ATFMK Monoglyceridelipase_lysophospholip ketone Trifluoro
AcACMK ACPH_Peptidase_S9 Peptide ketone Halo ketone Organochlorine
8-mercapto-1,1,1-tri-fluoro-2-octanone Juvenile_hormone_esterase Trifluoro Sulfur compound Halo ketone
Phenylacetone Monoglyceridelipase_lysophospholip ACHE ketone
Tosyl-L-lysine-chloromethyl-ketone Carb_B_Bacteria BCHE S9N_PREPL_Peptidase_S9 ketone Sulfur compound Sulfonamide Benzenesulfonamide Peptide Halo ketone Organochlorine
Difluoromethyl-ketone-BT7 ACHE ketone Pyrazole
1,3,4-oxadiazolyl-ketone-18h DPP4N_Peptidase_S9 Pyrrolidine ketone Oxadiazol tert-Butyl
Lilly-aryl-ketone DPP4N_Peptidase_S9 ketone
2-Tridecanone Hydroxynitrile_lyase Natural ketone
6AX1-cp3 Monoglyceridelipase_lysophospholip Halo ketone Trifluoro Carbamate Azetidin Oxadiazol
Acetone Hydroxynitrile_lyase ketone
Hexafluoracetone Hydroxynitrile_lyase Trifluoro Halo ketone
OTFP Juvenile_hormone_esterase Cutinase Trifluoro Halo ketone Sulfur compound
DETFP Juvenile_hormone_esterase Carb_B_Chordata Carboxylesterase Trifluoro Sulfur compound Halo ketone
OTFPdOHSO2 Juvenile_hormone_esterase Trifluoro Sulfur compound Sulfonyl Halo ketone
Z-Gly-Gly-Phe-chloromethyl-ketone ACPH_Peptidase_S9 Benzyloxycarbonyl Carbamate Peptide ketone Carboxamide Halo ketone Organochlorine
PHK Proline_iminopeptidase Peptide Halo ketone Organochlorine
JW651 Monoglyceridelipase_lysophospholip Plasmodium_subtelomeric_PST-A Piperazine Halo ketone Carbamate Trifluoro Organochlorine
KML29 Monoglyceridelipase_lysophospholip Plasmodium_subtelomeric_PST-A Halo ketone Piperidine Benzodioxo Carbamate Trifluoro
Zifrosilone ACHE Halo ketone Transition state analogue Trifluoro
1-Chloro-3-phenoxy-2-propanone ACHE Halo ketone ketone Organochlorine Transition state analogue
1-phenoxypropanone ACHE ketone Transition state analogue
6-Dimethyl-3-difluoro-2-heptanone ACHE Halo ketone Transition state analogue Analogue of substrate
6-Methyl-2-heptanone ketone
Coumarinyl-ethyl-p-trifluoroacetamidophenylmethylphosphonate BCHE Trifluoro Organophosphate Halo ketone Coumarin Chromen
TBTFA ACHE BCHE Halo ketone Transition state analogue Trifluoro tert-Butyl
MBTFP Cutinase Juvenile_hormone_esterase Trifluoro Transition state analogue Halo ketone Sulfur compound
TMTFA ACHE Trifluoro Trimethylammonium Ammonium Quaternary compound Transition state analogue Halo ketone
Trifluoro-6-dimethyl-2-heptanone BCHE ACHE Trifluoro Halo ketone