Pyranocoumarin-4-trifluoromethylphenyl-carboxylate-Cpd4i
IC50 AChE 0.0268 microM
General
Type : Chromen, Coumarin, Trifluoro, Carboxylate
Chemical_Nomenclature : Ethyl 2-hydroxy-2-methyl-5-oxo-4-(4-trifluoromethylphenyl)-3,4-dihydro-2H,5H-pyrano[3,2-c]chromene-3-carboxylate
Canonical SMILES : C1=CC=C2C(=C1)C3=C(C(O2)=O)C(C(C(O3)(O)C)C(=O)OCC)C4=CC=C(C=C4)C(F)(F)F
InChI : InChI=1S\/C23H19F3O6\/c1-3-30-21(28)18-16(12-8-10-13(11-9-12)23(24,25)26)17-19(32-22(18,2)29)14-6-4-5-7-15(14)31-20(17)27\/h4-11,16,18,29H,3H2,1-2H3
InChIKey : HZXCNJBLXJYPCD-UHFFFAOYSA-N
Other name(s) : Cyclocoumarol-trifluoromethylphenyl || Compound 4i
Target
Families : Pyranocoumarin-4-trifluoromethylphenyl-carboxylate-Cpd4i ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Design, synthesis, and evaluation of pyrano[3,2-c]coumarin derivatives for simultaneous targeting of amyloid-beta(42) and acetylcholinesterase in transgenic AD model of Drosophila - Sharma_2026_RSC.Adv__ |
| Author(s) : Sharma S , Raghuvanshi V , Kumari S , Singh S , Butcher RJ , Srikrishna S , Katiyar D |
| Ref : RSC Adv , : , 2026 |
| Abstract : |
| PubMedSearch : Sharma_2026_RSC.Adv__ |
| PubMedID: 42553843 |