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Coumarin

General

Coumarin is derived from coumarou, the French word for the tonka bean. Some naturally occurring coumarin derivatives include umbelliferone (7-hydroxycoumarin), aesculetin (6,7-dihydroxycoumarin), herniarin (7-methoxycoumarin), psoralen and imperatorin
Inhibitor Main targeted enzyme families Type Structure
Indol-ethyl-dimethyloctadienyl-oxy-chromene-carboxamide-Cpd7b Pancreatic_lipase Indole Chromen Carboxamide Coumarin
Chromene-Phenylpiperazine-Chalcone-Cpd9s BCHE Chalcone Monoamine-oxidase-inhibitor Piperazine Multitarget Chromen anti-Abeta-aggregation Coumarin
Benzothiazol-piperidin-ethoxy-chromen-Cpd13a ACHE Piperidine Coumarin Chromen Thiazole Benzothiazol Sulfur Compound
Benzothiazol-morpholino-ethoxy-chromen-Cpd13m ACHE BCHE Morpholine Coumarin Chromen Thiazole Benzothiazol Sulfur Compound
Chromen-oxybutanoyloxyethyl-triazol-ethyl-tacrine-Cpd17d ACHE BCHE Monoamine-oxidase-inhibitor Multitarget Chromen anti-Abeta-aggregation Derivative of Tacrine Acridine Coumarin Triazol
CHEMBL5429715 Pyrazole Chromen Coumarin
Fluoro-methylpiperazin-phenyl-oxo-chromene-carboxamide-CpdE12 ACHE Monoamine-oxidase-inhibitor Multitarget Piperazine Carboxamide Chromen Coumarin anti-Abeta-aggregation anti-tau-aggregation
6-hydroxychromone-hydrazone-Cpd3e ACHE Multitarget Carbonic anhydrase inhibitor Chromen Coumarin Naphthalen Hydrazide
Oxo-chromen-iminomethyl-phenoxy-phenylacetamide-Cpd10f ACHE BCHE Multitarget Chromen GSK-3 kinase inhibitor Coumarin
Benzyloxy-phenylthiazol-ylidenehydrazonomethyl-chromenone-Cpd5b ACHE Chromen Thiazole Sulfur Compound Coumarin
Quinoline-Coulmarin-CpdB8 BCHE Quinoline Coumarin Chromen Multitarget
Met-Gly-Pro-AMC DPP4N_Peptidase_S9 Coumarin Chromen 7-amido-4-methylcoumarin Peptide Pyrrolidine Sulfur Compound
CHEMBL4787798 ACHE Chromen Coumarin Catechol
Benzyl-triazol-piperidin-ethoxy-coumarin-Cpdh1 ACHE Multitarget Coumarin Chromen Triazol Piperidine Histamine-Receptor3-H3-Antagonist Monoamine-oxidase-inhibitor
3-(4-(dimethylamino)phenyl)-7-aminoethoxy-coumarin-Cpd6a ACHE Multitarget Coumarin Piperidine Chromen
CHEMBL4586480 ACHE Triazol Alkyl linked bis-ligand Multitarget Coumarin Chromen Organochlorine
CHEMBL3322160 ACHE BCHE Acridine Derivative of Tacrine Alkyl linked bis-ligand Multitarget Coumarin Chromen
Diethylamino-chromen-thiazol-acetamide ACHE Thiazole Sulfur Compound Coumarin Chromen
AP2238 ACHE Multitarget Coumarin anti-Abeta-aggregation Chromen
Coumarin-phosphazide-Cpd8b ACHE BCHE Multitarget Coumarin anti-Abeta-aggregation Chromen Hydrazinylidene Hydrazide Diazenyl
Coumarin-dimethoxyphenyl-methylpiperidine-carboxamise-cpd3b ACHE Coumarin Piperidine Carboxamide Derivative of Donepezil Chromen Dimethoxyphenyl
3-aminocoumarin-N-benzylpyridinium-9h ACHE Coumarin Pyridine Chromen
JCP276 Coumarin Urea derivative Chromen Organochlorine
Coumarin-Pyridine-3f ACHE BCHE Coumarin Pyridine Pyridinium Chromen
7QAK-Cpd1 ACHE Monoamine-oxidase-inhibitor Multitarget Coumarin Chromen
7QB4-Cpd2 ACHE Monoamine-oxidase-inhibitor Multitarget Coumarin Chromen Benzylpiperidine Derivative of Donepezil
ABP-JCP251-bT Hormone-sensitive_lipase_like Coumarin Chromen Triazol ABPP-Probe Boron compound Boranuidatricyclo BODIPY-derivative Fluorescent Probe
JCP251 Hormone-sensitive_lipase_like A85-EsteraseD-FGH Coumarin Chromen Organochlorine
PE154 ACHE BCHE Derivative of Tacrine Acridine Multitarget Hydrazide Coumarin Chromen
CHEMBL440526 BCHE ACHE Multitarget Carbamate Coumarin Chromen
6RUA-3a BCHE Sulfur Compound Sulfonamide Coumarin Piperidine Carboxamide Naphthalen Chromen Benzylpiperidine Derivative of Donepezil
JU5 BCHE Coumarin Piperidine Carboxamide Naphthalen Sulfur Compound Thiazole Chromen
4-methylumbelliferyl-hexylphosphonate Canar_LipB Hormone-sensitive_lipase_like Organophosphate Coumarin Chromen
3-chloro-7-hydroxy-4-methylcoumarin BCHE ACHE Coumarin 7-amido-4-methylcoumarin Organochlorine
7-hydroxy-4-methylcoumarin Coumarin Chromen Leaving group 7-amido-4-methylcoumarin
Coumarinyl-ethyl-p-trifluoroacetamidophenylmethylphosphonate BCHE Trifluoro Organophosphate Halo ketone Coumarin Chromen
Coralox ACHE Coumarin Anthelmintic Insecticide Organophosphate Chromen Organochlorine
Coumaphos ACHE Coumarin Anthelmintic Insecticide Organophosphate Sulfur Compound Organothiophosphate Organochlorine Chromen
Scopoletin Coumarin Natural Chromen
Coumarin Coumarin Chromen Cinnamate
dMUP ACHE Organophosphate Coumarin Chromen
Methyl-DEUP Bacterial_lip_FamI.1 Organophosphate Coumarin Chromen
DEUP Cholesterol_esterase Hormone-sensitive_lipase_like Arylacetamide_deacetylase Carb_B_Arthropoda Organophosphate Coumarin Chromen
EMPC ACHE Organophosphate Coumarin Chromen 7-amido-4-methylcoumarin
Haloxon ACHE Organophosphate Coumarin
EMP-MeCyC ACHE Cyanide Organophosphate Flu-OP Nerve Agent V-series Surrogate OP Coumarin
CMP-MeCyC ACHE Organophosphate Flu-OP Nerve Agent G-series Surrogate OP Coumarin Derivative of Sarin Chromen Cyanide
PMP-MeCyC ACHE Organophosphate Flu-OP Nerve Agent G-series Surrogate OP Coumarin Derivative of Soman Chromen Cyanide
IMP-MeCyC ACHE Organophosphate Flu-OP Nerve Agent G-series Surrogate OP Derivative of Sarin Chromen Coumarin Cyanide
AChE-IN-27 ACHE Coumarin Cyanide Chromen
Indol-ethyl-dimethyloctadienyl-oxy-chromene-carboxamide-Cpd7b Pancreatic_lipase Indole Chromen Carboxamide Coumarin
Chromene-Phenylpiperazine-Chalcone-Cpd9s BCHE Chalcone Monoamine-oxidase-inhibitor Piperazine Multitarget Chromen anti-Abeta-aggregation Coumarin
Benzothiazol-piperidin-ethoxy-chromen-Cpd13a ACHE Piperidine Coumarin Chromen Thiazole Benzothiazol Sulfur Compound
Benzothiazol-morpholino-ethoxy-chromen-Cpd13m ACHE BCHE Morpholine Coumarin Chromen Thiazole Benzothiazol Sulfur Compound
Chromen-oxybutanoyloxyethyl-triazol-ethyl-tacrine-Cpd17d ACHE BCHE Monoamine-oxidase-inhibitor Multitarget Chromen anti-Abeta-aggregation Derivative of Tacrine Acridine Coumarin Triazol
CHEMBL5429715 Pyrazole Chromen Coumarin
Fluoro-methylpiperazin-phenyl-oxo-chromene-carboxamide-CpdE12 ACHE Monoamine-oxidase-inhibitor Multitarget Piperazine Carboxamide Chromen Coumarin anti-Abeta-aggregation anti-tau-aggregation
6-hydroxychromone-hydrazone-Cpd3e ACHE Multitarget Carbonic anhydrase inhibitor Chromen Coumarin Naphthalen Hydrazide
Oxo-chromen-iminomethyl-phenoxy-phenylacetamide-Cpd10f ACHE BCHE Multitarget Chromen GSK-3 kinase inhibitor Coumarin
Benzyloxy-phenylthiazol-ylidenehydrazonomethyl-chromenone-Cpd5b ACHE Chromen Thiazole Sulfur Compound Coumarin
Quinoline-Coulmarin-CpdB8 BCHE Quinoline Coumarin Chromen Multitarget
Met-Gly-Pro-AMC DPP4N_Peptidase_S9 Coumarin Chromen 7-amido-4-methylcoumarin Peptide Pyrrolidine Sulfur Compound
CHEMBL4787798 ACHE Chromen Coumarin Catechol
Benzyl-triazol-piperidin-ethoxy-coumarin-Cpdh1 ACHE Multitarget Coumarin Chromen Triazol Piperidine Histamine-Receptor3-H3-Antagonist Monoamine-oxidase-inhibitor
3-(4-(dimethylamino)phenyl)-7-aminoethoxy-coumarin-Cpd6a ACHE Multitarget Coumarin Piperidine Chromen
CHEMBL4586480 ACHE Triazol Alkyl linked bis-ligand Multitarget Coumarin Chromen Organochlorine
CHEMBL3322160 ACHE BCHE Acridine Derivative of Tacrine Alkyl linked bis-ligand Multitarget Coumarin Chromen
Diethylamino-chromen-thiazol-acetamide ACHE Thiazole Sulfur Compound Coumarin Chromen
AP2238 ACHE Multitarget Coumarin anti-Abeta-aggregation Chromen
Coumarin-phosphazide-Cpd8b ACHE BCHE Multitarget Coumarin anti-Abeta-aggregation Chromen Hydrazinylidene Hydrazide Diazenyl
Coumarin-dimethoxyphenyl-methylpiperidine-carboxamise-cpd3b ACHE Coumarin Piperidine Carboxamide Derivative of Donepezil Chromen Dimethoxyphenyl
3-aminocoumarin-N-benzylpyridinium-9h ACHE Coumarin Pyridine Chromen
JCP276 Coumarin Urea derivative Chromen Organochlorine
Coumarin-Pyridine-3f ACHE BCHE Coumarin Pyridine Pyridinium Chromen
7QAK-Cpd1 ACHE Monoamine-oxidase-inhibitor Multitarget Coumarin Chromen
7QB4-Cpd2 ACHE Monoamine-oxidase-inhibitor Multitarget Coumarin Chromen Benzylpiperidine Derivative of Donepezil
ABP-JCP251-bT Hormone-sensitive_lipase_like Coumarin Chromen Triazol ABPP-Probe Boron compound Boranuidatricyclo BODIPY-derivative Fluorescent Probe
JCP251 Hormone-sensitive_lipase_like A85-EsteraseD-FGH Coumarin Chromen Organochlorine
PE154 ACHE BCHE Derivative of Tacrine Acridine Multitarget Hydrazide Coumarin Chromen
CHEMBL440526 BCHE ACHE Multitarget Carbamate Coumarin Chromen
6RUA-3a BCHE Sulfur Compound Sulfonamide Coumarin Piperidine Carboxamide Naphthalen Chromen Benzylpiperidine Derivative of Donepezil
JU5 BCHE Coumarin Piperidine Carboxamide Naphthalen Sulfur Compound Thiazole Chromen
4-methylumbelliferyl-hexylphosphonate Canar_LipB Hormone-sensitive_lipase_like Organophosphate Coumarin Chromen
3-chloro-7-hydroxy-4-methylcoumarin BCHE ACHE Coumarin 7-amido-4-methylcoumarin Organochlorine
7-hydroxy-4-methylcoumarin Coumarin Chromen Leaving group 7-amido-4-methylcoumarin
Coumarinyl-ethyl-p-trifluoroacetamidophenylmethylphosphonate BCHE Trifluoro Organophosphate Halo ketone Coumarin Chromen
Coralox ACHE Coumarin Anthelmintic Insecticide Organophosphate Chromen Organochlorine
Coumaphos ACHE Coumarin Anthelmintic Insecticide Organophosphate Sulfur Compound Organothiophosphate Organochlorine Chromen
Scopoletin Coumarin Natural Chromen
Coumarin Coumarin Chromen Cinnamate
dMUP ACHE Organophosphate Coumarin Chromen
Methyl-DEUP Bacterial_lip_FamI.1 Organophosphate Coumarin Chromen
DEUP Cholesterol_esterase Hormone-sensitive_lipase_like Arylacetamide_deacetylase Carb_B_Arthropoda Organophosphate Coumarin Chromen
EMPC ACHE Organophosphate Coumarin Chromen 7-amido-4-methylcoumarin
Haloxon ACHE Organophosphate Coumarin
EMP-MeCyC ACHE Cyanide Organophosphate Flu-OP Nerve Agent V-series Surrogate OP Coumarin
CMP-MeCyC ACHE Organophosphate Flu-OP Nerve Agent G-series Surrogate OP Coumarin Derivative of Sarin Chromen Cyanide
PMP-MeCyC ACHE Organophosphate Flu-OP Nerve Agent G-series Surrogate OP Coumarin Derivative of Soman Chromen Cyanide
IMP-MeCyC ACHE Organophosphate Flu-OP Nerve Agent G-series Surrogate OP Derivative of Sarin Chromen Coumarin Cyanide
AChE-IN-27 ACHE Coumarin Cyanide Chromen
Indol-ethyl-dimethyloctadienyl-oxy-chromene-carboxamide-Cpd7b Pancreatic_lipase Indole Chromen Carboxamide Coumarin
Chromene-Phenylpiperazine-Chalcone-Cpd9s BCHE Chalcone Monoamine-oxidase-inhibitor Piperazine Multitarget Chromen anti-Abeta-aggregation Coumarin
Benzothiazol-piperidin-ethoxy-chromen-Cpd13a ACHE Piperidine Coumarin Chromen Thiazole Benzothiazol Sulfur Compound
Benzothiazol-morpholino-ethoxy-chromen-Cpd13m ACHE BCHE Morpholine Coumarin Chromen Thiazole Benzothiazol Sulfur Compound
Chromen-oxybutanoyloxyethyl-triazol-ethyl-tacrine-Cpd17d ACHE BCHE Monoamine-oxidase-inhibitor Multitarget Chromen anti-Abeta-aggregation Derivative of Tacrine Acridine Coumarin Triazol
CHEMBL5429715 Pyrazole Chromen Coumarin
Fluoro-methylpiperazin-phenyl-oxo-chromene-carboxamide-CpdE12 ACHE Monoamine-oxidase-inhibitor Multitarget Piperazine Carboxamide Chromen Coumarin anti-Abeta-aggregation anti-tau-aggregation
6-hydroxychromone-hydrazone-Cpd3e ACHE Multitarget Carbonic anhydrase inhibitor Chromen Coumarin Naphthalen Hydrazide
Oxo-chromen-iminomethyl-phenoxy-phenylacetamide-Cpd10f ACHE BCHE Multitarget Chromen GSK-3 kinase inhibitor Coumarin
Benzyloxy-phenylthiazol-ylidenehydrazonomethyl-chromenone-Cpd5b ACHE Chromen Thiazole Sulfur Compound Coumarin
Quinoline-Coulmarin-CpdB8 BCHE Quinoline Coumarin Chromen Multitarget
Met-Gly-Pro-AMC DPP4N_Peptidase_S9 Coumarin Chromen 7-amido-4-methylcoumarin Peptide Pyrrolidine Sulfur Compound
CHEMBL4787798 ACHE Chromen Coumarin Catechol
Benzyl-triazol-piperidin-ethoxy-coumarin-Cpdh1 ACHE Multitarget Coumarin Chromen Triazol Piperidine Histamine-Receptor3-H3-Antagonist Monoamine-oxidase-inhibitor
3-(4-(dimethylamino)phenyl)-7-aminoethoxy-coumarin-Cpd6a ACHE Multitarget Coumarin Piperidine Chromen
CHEMBL4586480 ACHE Triazol Alkyl linked bis-ligand Multitarget Coumarin Chromen Organochlorine
CHEMBL3322160 ACHE BCHE Acridine Derivative of Tacrine Alkyl linked bis-ligand Multitarget Coumarin Chromen
Diethylamino-chromen-thiazol-acetamide ACHE Thiazole Sulfur Compound Coumarin Chromen
AP2238 ACHE Multitarget Coumarin anti-Abeta-aggregation Chromen
Coumarin-phosphazide-Cpd8b ACHE BCHE Multitarget Coumarin anti-Abeta-aggregation Chromen Hydrazinylidene Hydrazide Diazenyl
Coumarin-dimethoxyphenyl-methylpiperidine-carboxamise-cpd3b ACHE Coumarin Piperidine Carboxamide Derivative of Donepezil Chromen Dimethoxyphenyl
3-aminocoumarin-N-benzylpyridinium-9h ACHE Coumarin Pyridine Chromen
JCP276 Coumarin Urea derivative Chromen Organochlorine
Coumarin-Pyridine-3f ACHE BCHE Coumarin Pyridine Pyridinium Chromen
7QAK-Cpd1 ACHE Monoamine-oxidase-inhibitor Multitarget Coumarin Chromen
7QB4-Cpd2 ACHE Monoamine-oxidase-inhibitor Multitarget Coumarin Chromen Benzylpiperidine Derivative of Donepezil
ABP-JCP251-bT Hormone-sensitive_lipase_like Coumarin Chromen Triazol ABPP-Probe Boron compound Boranuidatricyclo BODIPY-derivative Fluorescent Probe
JCP251 Hormone-sensitive_lipase_like A85-EsteraseD-FGH Coumarin Chromen Organochlorine
PE154 ACHE BCHE Derivative of Tacrine Acridine Multitarget Hydrazide Coumarin Chromen
CHEMBL440526 BCHE ACHE Multitarget Carbamate Coumarin Chromen
6RUA-3a BCHE Sulfur Compound Sulfonamide Coumarin Piperidine Carboxamide Naphthalen Chromen Benzylpiperidine Derivative of Donepezil
JU5 BCHE Coumarin Piperidine Carboxamide Naphthalen Sulfur Compound Thiazole Chromen
4-methylumbelliferyl-hexylphosphonate Canar_LipB Hormone-sensitive_lipase_like Organophosphate Coumarin Chromen
3-chloro-7-hydroxy-4-methylcoumarin BCHE ACHE Coumarin 7-amido-4-methylcoumarin Organochlorine
7-hydroxy-4-methylcoumarin Coumarin Chromen Leaving group 7-amido-4-methylcoumarin
Coumarinyl-ethyl-p-trifluoroacetamidophenylmethylphosphonate BCHE Trifluoro Organophosphate Halo ketone Coumarin Chromen
Coralox ACHE Coumarin Anthelmintic Insecticide Organophosphate Chromen Organochlorine
Coumaphos ACHE Coumarin Anthelmintic Insecticide Organophosphate Sulfur Compound Organothiophosphate Organochlorine Chromen
Scopoletin Coumarin Natural Chromen
Coumarin Coumarin Chromen Cinnamate
dMUP ACHE Organophosphate Coumarin Chromen
Methyl-DEUP Bacterial_lip_FamI.1 Organophosphate Coumarin Chromen
DEUP Cholesterol_esterase Hormone-sensitive_lipase_like Arylacetamide_deacetylase Carb_B_Arthropoda Organophosphate Coumarin Chromen
EMPC ACHE Organophosphate Coumarin Chromen 7-amido-4-methylcoumarin
Haloxon ACHE Organophosphate Coumarin
EMP-MeCyC ACHE Cyanide Organophosphate Flu-OP Nerve Agent V-series Surrogate OP Coumarin
CMP-MeCyC ACHE Organophosphate Flu-OP Nerve Agent G-series Surrogate OP Coumarin Derivative of Sarin Chromen Cyanide
PMP-MeCyC ACHE Organophosphate Flu-OP Nerve Agent G-series Surrogate OP Coumarin Derivative of Soman Chromen Cyanide
IMP-MeCyC ACHE Organophosphate Flu-OP Nerve Agent G-series Surrogate OP Derivative of Sarin Chromen Coumarin Cyanide
AChE-IN-27 ACHE Coumarin Cyanide Chromen