Pyrazoline-Thiazole-Cpd3f
AChE IC50 0.382, Ki 0.057 +/- 0.003 BChE IC50 4.252 Ki 1.456 +/- 0.071
General
Type : Pyrazole, Pyrazoline, Thiophen, Sulfur Compound, Thiazole, pNP, Dimethoxyphenyl
Chemical_Nomenclature : 2-[3-(3,4-Dimethoxyphenyl)-5-(5-methylthiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-(4-nitrophenyl)thiazole
Canonical SMILES : C1=CC(=CC(=C1OC)OC)C2=NN(C(C2)C)C3=NC(=CS3)C4=CC=C([N+](=O)[O-])C=C4
InChI : InChI=1S\/C21H20N4O4S\/c1-13-10-17(15-6-9-19(28-2)20(11-15)29-3)23-24(13)21-22-18(12-30-21)14-4-7-16(8-5-14)25(26)27\/h4-9,11-13H,10H2,1-3H3
InChIKey : YZJJVBNFXVOSEG-UHFFFAOYSA-N
Other name(s) : Copound 3f
Target
References (1)
| Title : Design, Synthesis, and Molecular Docking Studies of Novel Pyrazoline-Thiazoles as Cholinesterase Dual-Target Inhibitors for the Treatment of Alzheimer's Disease - Kaya_2025_ACS.Omega_10_38427 |
| Author(s) : Kaya B , Cevik UA , Ciftci B , Necip A , Isik M , Ay EN , Yur S , Ozkay Y , Beydemir S , Kaplancikli ZA |
| Ref : ACS Omega , 10 :38427 , 2025 |
| Abstract : |
| PubMedSearch : Kaya_2025_ACS.Omega_10_38427 |
| PubMedID: 40918343 |