Pyrazoline-Thiazole-Cpd3g
AChE IC50 0.338, Ki 0.045 +/- 0.002; BChE IC50 2.087, Ki 0.789 +/- 0.056
General
Type : Pyrazole, Pyrazoline, Thiophen, Sulfur Compound, Thiazole, Dimethoxyphenyl, Cyanide
Chemical_Nomenclature : 2-[3-(3,4-Dimethoxyphenyl)-5-(5-methylthiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-(4-cyanophenyl)thiazole
Canonical SMILES : C1=CC(=CC(=C1OC)OC)C2=NN(C(C2)C)C3=NC(=CS3)C4=CC=C(C=C4)C#N
InChI : InChI=1S\/C22H20N4O2S\/c1-14-10-18(17-8-9-20(27-2)21(11-17)28-3)25-26(14)22-24-19(13-29-22)16-6-4-15(12-23)5-7-16\/h4-9,11,13-14H,10H2,1-3H3
InChIKey : YFAIHEMXCSJNLM-UHFFFAOYSA-N
Other name(s) : Copound 3g
Target
References (3)
| Title : Design, Synthesis, and Molecular Docking Studies of Novel Pyrazoline-Thiazoles as Cholinesterase Dual-Target Inhibitors for the Treatment of Alzheimer's Disease - Kaya_2025_ACS.Omega_10_38427 |
| Author(s) : Kaya B , Cevik UA , Ciftci B , Necip A , Isik M , Ay EN , Yur S , Ozkay Y , Beydemir S , Kaplancikli ZA |
| Ref : ACS Omega , 10 :38427 , 2025 |
| Abstract : |
| PubMedSearch : Kaya_2025_ACS.Omega_10_38427 |
| PubMedID: 40918343 |
| Title : Design, Synthesis, and Molecular Docking Studies of Novel Pyrazoline-Thiazoles as Cholinesterase Dual-Target Inhibitors for the Treatment of Alzheimer's Disease - Kaya_2025_ACS.Omega_10_38427 |
| Author(s) : Kaya B , Cevik UA , Ciftci B , Necip A , Isik M , Ay EN , Yur S , Ozkay Y , Beydemir S , Kaplancikli ZA |
| Ref : ACS Omega , 10 :38427 , 2025 |
| Abstract : |
| PubMedSearch : Kaya_2025_ACS.Omega_10_38427 |
| PubMedID: 40918343 |
| Title : Design, Synthesis, and Molecular Docking Studies of Novel Pyrazoline-Thiazoles as Cholinesterase Dual-Target Inhibitors for the Treatment of Alzheimer's Disease - Kaya_2025_ACS.Omega_10_38427 |
| Author(s) : Kaya B , Cevik UA , Ciftci B , Necip A , Isik M , Ay EN , Yur S , Ozkay Y , Beydemir S , Kaplancikli ZA |
| Ref : ACS Omega , 10 :38427 , 2025 |
| Abstract : |
| PubMedSearch : Kaya_2025_ACS.Omega_10_38427 |
| PubMedID: 40918343 |