Pyrrolidin-ethyl-fluorobenzyloxybenzothioate-cpd28c
AChE (IC50 = 1.70 microM) and MAO-B (IC50 = 0.18 microM)
General
Type : Monoamine-oxidase-inhibitor, Multitarget, Sulfur Compound, Pyrrolidine
Chemical_Nomenclature : S-(2-(pyrrolidin-1-yl)ethyl) 4-((3-fluorobenzyl)oxy)benzothioate
Canonical SMILES : C1(=CC=CC(=C1)COC2=CC=C(C=C2)C(SCCN3CCCC3)=O)F
InChI : InChI=1S\/C20H22FNO2S\/c21-18-5-3-4-16(14-18)15-24-19-8-6-17(7-9-19)20(23)25-13-12-22-10-1-2-11-22\/h3-9,14H,1-2,10-13,15H2
InChIKey : URRKQWFDTDBDOZ-UHFFFAOYSA-N
Other name(s) : Compound 28c
Target
References (1)
| Title : Design, synthesis and biological evaluation of donepezil-safinamide hybrids as dual AChE and MAO-B inhibitor for Alzheimer's disease treatment - Li_2026_J.Enzyme.Inhib.Med.Chem_41_2622769 |
| Author(s) : Li W , Guo Y , Wang X , Yang C , Zhu J , Cao Z |
| Ref : J Enzyme Inhib Med Chem , 41 :2622769 , 2026 |
| Abstract : |
| PubMedSearch : Li_2026_J.Enzyme.Inhib.Med.Chem_41_2622769 |
| PubMedID: 41645766 |