Quinolyl-methylene-hydrazono-thiazol-pyrocatechol-Cpd3i
3i IC50 AChE 0.027 +/- 0.002 microM; IC50 BChE >10 microM
General
Type : Hydrazide, Quinoline, Catechol, Thiazole, Sulfur Compound
Chemical_Nomenclature : 4-[(2E)-3-ethyl-2-[(2E)-2-[(quinolin-4-yl)methylidene]hydrazono]-2,3-dihydro-1,3-thiazol-4-yl]benzene-1,2-diol
Canonical SMILES : C1=CC=C2C(=C1)C(=CC=N2)C=NN=C3\/N(C(=CS3)C4=CC(=C(C=C4)O)O)CC
InChI : InChI=1S\/C21H18N4O2S\/c1-2-25-18(14-7-8-19(26)20(27)11-14)13-28-21(25)24-23-12-15-9-10-22-17-6-4-3-5-16(15)17\/h3-13,26-27H,2H2,1H3
InChIKey : HCTOPJQNQDOKLL-UHFFFAOYSA-N
Other name(s) : Compound 3i || 4-[(E)-3-Ethyl-2-[(E)-2-[(4-quinolyl)methylene]hydrazono]-2,3-dihydro-1,3-thiazol-4-yl]pyrocatechol || 4-(3-Ethyl-2-((quinolin-4-ylmethylene)hydrazineylidene)-2,3-dihydrothiazol-4-yl)benzene-1,2-diol
Target
Families : Quinolyl-methylene-hydrazono-thiazol-pyrocatechol-Cpd3i ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Quinoline\/thiazole compounds as selective acetylcholinesterase inhibitors: synthesis and biological assessment - Kurban_2026_RSC.Med.Chem__ |
| Author(s) : Kurban B , Osmaniye D , Levent S , Ozkay Y , Kaplancikli ZA |
| Ref : RSC Med Chem , : , 2026 |
| Abstract : |
| PubMedSearch : Kurban_2026_RSC.Med.Chem__ |
| PubMedID: 42037743 |