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Quinoline

General

Quinoline is a heterocyclic aromatic organic compound with the chemical formula C9H7N. 1-Benzopyridine. Building block for many inhibitors of enzymes
Inhibitor Main targeted enzyme families Type Structure
CHEMBL4245414-Cpd2g DPP4N_Peptidase_S9 Quinoline Piperazine Pyrrolidine
CHEMBL4085222 BCHE Derivative of Donepezil Piperidine Benzylpiperidine Quinoline Feruloyl
Deriv-CHEMBL4085222-Cpd8e BCHE Feruloyl Derivative of Donepezil Piperidine Benzylpiperidine Quinoline
Corydaline ACHE Alkaloid Natural Quinoline
TA8Amino ACHE Derivative of Tacrine Derivative of Donepezil Quinoline Piperidine Inden
TAHB3 ACHE Derivative of Tacrine Derivative of Donepezil Piperidine Inden Quinoline
NPD14805 RsbQ-like Strigolactone receptors ligand Quinoline
DC661 Palmitoyl-protein_thioesterase Quinoline
Ferulic-Acid-Piperazine-Cpd13a ACHE Multitarget Piperazine Quinoline Feruloyl Metal ion chelator anti-Abeta-aggregation Antioxidant
DJ-53 Epoxide_hydrolase Urea derivative Quinoline Trifluoro
WZU-13 Carb_B_Chordata Benzamide Carboxamide Quinoline
CHEMBL4240861 ACHE Inden Multitarget BACE1-inhibitor Quinoline
Ezurpimtrostat Palmitoyl-protein_thioesterase Piperidine Quinoline
S21-1001 BCHE Piperazine Quinoline
BuChE-IN-TM-10 BCHE Feruloyl Hydroxycinnamic-ester Multitarget Isoquinoline Monoamine-oxidase-inhibitor
CHEMBL4177075 ACHE Carbamate Quinoline
CHEMBL4177075-INDY ACHE BCHE Multitarget Benzothiazol Carbamate Quinoline Sulfur Compound
Di-tert-butyl-phenol-octylamino-cycloheptaquinolin-18d BCHE Multitarget Derivative of Tacrine Quinoline Antioxidant tert-Butyl Alkyl linked bis-ligand
(S)Aporphine-N-benzylpyridinium ACHE Isoquinoline Pyridine Alkaloid
Amiridine-Admantyl-5d BCHE Quinoline Derivative of Tacrine Derivative of Amiridine Adamantyl NMDA-Ligand Multitarget Naphthalen
Amiridine-thiouracil-13c BCHE Quinoline Derivative of Tacrine Derivative of Amiridine Pyrimidine Sulfur Compound anti-Abeta-aggregation
BR102910 DPP4N_Peptidase_S9 Quinoline Carboxamide Pyrrolidine Cyanide Sulfur Compound
UAMC-1110 DPP4N_Peptidase_S9 Quinoline Carboxamide Pyrrolidine Cyanide
IOCB22-AP446 DPP4N_Peptidase_S9 Pyrrolidine Quinoline Carboxamide
spiro-b-lactam-pyrroloquinoline-6b S9N_PPCE_Peptidase_S9 Azaspiro beta-Lactam Pyrrolidine Quinoline
O-Methyl-Dauracine DPP4N_Peptidase_S9 Alkaloid Natural Quinoline
J8-A34 ACHE Piperidine Sulfur Compound Sulfonamide Quinoline Derivative of Donepezil
Compound19n-quinolinol ACHE Trifluoro anti-Abeta-aggregation Metal ion chelator Quinoline Multitarget Derivative of Donepezil
JS0-7ZPB BCHE Quinoline Piperazine Multitarget Monoamine-oxidase-inhibitor Alkyne
WMY90-5f ACHE Quinoline Multitarget Monoamine-oxidase-inhibitor Derivative of Donepezil Alkyne Cyanide
DPH6 BCHE ACHE Quinoline Multitarget Monoamine-oxidase-inhibitor Derivative of Donepezil Alkyne Cyanide
AI6-7QBR BCHE Quinoline Piperazine tert-Butyl Multitarget Monoamine-oxidase-inhibitor Alkyne
AI0-7QBQ BCHE ACHE Quinoline Multitarget Monoamine-oxidase-inhibitor
Di-tert-butyl-4-Amino-2,3-cycloheptaquinoline-8c BCHE Quinoline Multitarget Antioxidant tert-Butyl
Cinchonidine BCHE Natural Alkaloid Derivative of Cinchonine Quinoline Azabicyclo
Cinchonine BCHE Natural Alkaloid Derivative of Cinchonine Quinoline Azabicyclo
CD-Bzl BCHE Alkaloid Derivative of Cinchonine Quinoline Natural_modified
Tacrine-dihydropyrimidine-4e ACHE Multitarget Derivative of Tacrine Calcium Channel Antagonist Sulfur Compound Quinoline Pyrimidine
M30D ACHE Monoamine-oxidase-inhibitor Multitarget Carbamate Quinoline Alkyne
Cpd8f-quinoline-carboxamide Hormone-sensitive_lipase_like Quinoline Carboxamide
WWL153 PAF-Acetylhydrolase Piperazine Quinoline pNP
JMN4 PAF-Acetylhydrolase Piperazine Quinoline
(Isoquinolin-1-ylsulfanyl)-acetic-acid Pectinacetylesterase-Notum Fragment inhibitor of Notum Isoquinoline Quinoline Sulfur Compound
VL1-8MH Haloalkane_dehalogenase-HLD2 Fluorescent Probe HaloTag-ligand Isoquinoline Quinoline
Emetine Hydrolase_RBBP9_YdeN Natural Alkaloid Drug Isoquinoline Quinoline Quinolizine
8U2-7AIX7AY-compound5i ACHE BCHE Derivative of Huperzine Quinoline Alkyl linked bis-ligand Multitarget Derivative of Capsaicin Antioxidant Triazol
8U5-7AIW-compound5g ACHE Derivative of Huperzine Quinoline Alkyl linked bis-ligand Multitarget Derivative of Capsaicin Antioxidant
8UE-7AIV-compound5f ACHE Derivative of Huperzine Quinoline Alkyl linked bis-ligand Multitarget Derivative of Capsaicin Antioxidant
8UQ-7AIU-compound5d ACHE Derivative of Huperzine Quinoline Alkyl linked bis-ligand Multitarget Derivative of Capsaicin Antioxidant
8UK-7AIT-compound5c ACHE Derivative of Huperzine Quinoline Alkyl linked bis-ligand Multitarget Derivative of Capsaicin Antioxidant
8UH-7AIS-compound5b ACHE Derivative of Huperzine Quinoline Alkyl linked bis-ligand Multitarget Derivative of Capsaicin Antioxidant
SB31184-49R-4Y2U Epoxide_hydrolase Carbamate Quinoline tert-Butyloxycarbonyl tert-Butyl
beta-lactam-A295 DPP4N_Peptidase_S9 Quinoline Piperazine
4-Oxo-beta-Lactam-91-sub DPP4N_Peptidase_S9 Isoquinoline beta-Lactam Azetidin
4-Oxo-beta-Lactam-91 DPP4N_Peptidase_S9 Isoquinoline beta-Lactam
CHEMBL2152538 Not AlphaBeta Hydrolase target Isoquinoline Quinazoline Leaving group
Columbamine ACHE Natural Alkaloid Not AlphaBeta Hydrolase target Isoquinoline
Palmatine ACHE Natural Alkaloid Not AlphaBeta Hydrolase target Isoquinoline
Berberine ACHE BCHE Natural Alkaloid Not AlphaBeta Hydrolase target Isoquinoline Benzodioxo Antioxidant
S06-1011 BCHE Quinoline Imidazole Oxadiazol Benzimidazole
Tetracyclic-carbamate-cp8 BCHE PET probe Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline
Tetracyclic-carbamate-melatonine-3c BCHE Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline Derivative of Tryptamine Indole Alkyl linked bis-ligand
Tetracyclic-carbamate-ferulicacid-4a BCHE Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline Feruloyl Antioxidant Alkyl linked bis-ligand
Tetracyclic-carbamate-UW-MD-95 BCHE Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline
Chlorophenyl-quinolin-1,3,4-oxadiazol-thio-acetamide ACHE Sulfur Compound Quinoline Oxadiazol Carboxamide
CHEMBL4454960 BCHE Morpholine Isoquinoline Carbamate Quinazoline
ZINC20166201-cpd8 BCHE Piperazine Quinoline
8012-9656 BCHE Quinoline Imidazole Oxadiazol Benzimidazole
Isoquinoline-45-JV8 Pectinacetylesterase-Notum Isoquinoline
Tetracyclic-carbamate-photoswitch-azo BCHE Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline Photoswitch
6F7Q-cpd11 BCHE Multitarget Antioxidant Piperidine Quinoline Metal ion chelator Inden Carboxamide
Amodiaquine ACHE Quinoline Not AlphaBeta Hydrolase target Drug
FAPI-46 DPP4N_Peptidase_S9 Piperazine Quinoline PET probe Carboxamide Tetrazacyclododec Cyanide
FAPI-74 DPP4N_Peptidase_S9 Piperazine Quinoline PET probe Cyanide
FAPI-02 DPP4N_Peptidase_S9 Piperazine Quinoline PET probe Carboxamide Tetrazacyclododec Cyanide
FAPI-04 DPP4N_Peptidase_S9 Piperazine Quinoline PET probe Carboxamide Tetrazacyclododec Cyanide
CHEMBL1951424 DPP4N_Peptidase_S9 Piperidine Cyanide Quinoline Pyrrolidine
CHEMBL2058971 DPP4N_Peptidase_S9 Trifluoro Pyrrolidine Quinoline Thiazolidine Sulfur Compound
TAK-294 DPP4N_Peptidase_S9 Isoquinoline
Tetrahydroisoquinoline-derivative DPP4N_Peptidase_S9 Isoquinoline Carboxamide
Donepezil-8-Hydroxyquinoline-2b BCHE Quinoline Multitarget Antioxidant Derivative of Donepezil
ST052207 BCHE Quinoline Carbazol beta-carboline
CHEMBL3125351 Cholesterol_esterase Quinoline Indole
CHEMBL3125346 Cholesterol_esterase Quinoline Indole
Tacrine(8)-4-aminoquinoline ACHE Derivative of Tacrine Quinoline Alkyl linked bis-ligand
40V BCHE Piperidine Quinoline Multitarget Carboxamide Metal ion chelator Inden
T-82(1) ACHE Piperidine Quinoline Benzylpiperidine
TZ2PIQA5 ACHE Acridine Quinoline Derivative of Propidium Derivative of Tacrine Alkyl linked bis-ligand Triazol
FBQ ACHE Trifluoro Transition state analogue Quinoline Derivative of Tacrine Sulfur Compound
2-Methoxyhuprine ACHE Derivative of Huperzine Derivative of Tacrine Quinoline Natural_modified
Acridine ACHE Acridine Quinoline
Atracurium BCHE Not AlphaBeta Hydrolase target Neuromuscular Nondepolarizing Agents Drug Isoquinoline Propionate
Quinolinetrione-tacrine-Cpd3 ACHE Quinoline Multitarget Derivative of Tacrine Acridine Alkyl linked bis-ligand anti-Abeta-aggregation
DEPQ ACHE Organophosphate Quinoline
Dibucaine BCHE Local anesthetic Quinoline Drug Not AlphaBeta Hydrolase target Carboxamide
Naftalofos ACHE Insecticide Isoquinoline Organophosphate
Duador BCHE Pyrrolidine Neuromuscular Nondepolarizing Agents Quinoline Not AlphaBeta Hydrolase target
HuprineW ACHE Derivative of Huperzine Derivative of Tacrine Quinoline Natural_modified
HuprineX ACHE Derivative of Huperzine Derivative of Tacrine Quinoline Natural_modified
MEPQ ACHE Organophosphate Quinoline
BChE-IN-21 BCHE Pyridine Quinoline Carboxamide
Jatrorrhizine ACHE Natural Alkaloid Not AlphaBeta Hydrolase target Isoquinoline
Mivacurium BCHE Neuromuscular Nondepolarizing Agents Isoquinoline Bisquaternary Drug Not AlphaBeta Hydrolase target
N-Methyl-7-dimethylcarbamoxyquinolinium ACHE BCHE Carbamate Quinoline
N-Methyl-7-hydroxyquinolinium BCHE Quinoline
NIK-247 ACHE BCHE Quinoline Derivative of Tacrine Derivative of Amiridine
Tryptophan-tetrahydroisoquinoline-Cpd7g BCHE Quinoline Derivative of Tryptophan Isoquinoline
Bis-alkylene-Amiridine-3c BCHE Derivative of Amiridine Quinoline Alkyl linked bis-ligand
Quilostigmine ACHE Derivative of physostigmine-eserine Carbamate Isoquinoline Indole
(R)-Tacrine(10)-Hupyridone ACHE Derivative of Huperzine Derivative of Tacrine Quinoline Alkyl linked bis-ligand
(S,S)-(-)-bis(12)-hupyridone ACHE Derivative of Huperzine Quinoline Alkyl linked bis-ligand
(S,S)-(-)-bis(10)-hupyridone ACHE Derivative of Huperzine Quinoline Alkyl linked bis-ligand
Hupyridone ACHE Derivative of Huperzine Quinoline
Doxacurium BCHE Neuromuscular Nondepolarizing Agents Isoquinoline Bisquaternary Not AlphaBeta Hydrolase target
Cisatracurium BCHE Propionate Isoquinoline Neuromuscular Nondepolarizing Agents Nicotinic antagonist Bisquaternary Not AlphaBeta Hydrolase target