RLC14
RLC14, had an IC50 of 6.8x10-9 M human-EPHX2; and protected WT, but not in C521S sEH knock-in (KI) mice, isolated hearts from infarction during myocardial ischemia and reperfusion (IR). Inhibitory adduction of RCL14 to C521 of the hydrolase. Disulfide dimer of STOCK1N-36489
General
Type : Sulfur Compound
Chemical_Nomenclature : 3-(2-Carboxy-2-{3-[(2R,15S)-2,15-dimethyl-5-oxotetracyclo[8.7.0.02,7.011,15]heptadec-6-en-14-yloxycarbonyl]propionylamino}ethyldithio)-2-{3-[(2R,15S)-2,15-dimethyl-5-oxotetracyclo[8.7.0.02,7.011,15]heptadec-6-en-14-yloxycarbonyl]propionylamino}propionic acid
Canonical SMILES : C5(OC(CCC(NC(CSSCC(NC(CCC(OC1[C@@]2(C(CC1)C4C(CC2)[C@@]3(C(=CC(CC3)=O)CC4)C)C)=O)=O)C(O)=O)C(=O)O)=O)=O)[C@@]6(C(CC5)C8C(CC6)[C@@]7(C(=CC(CC7)=O)CC8)C)C
InChI : InChI=1S\/C52H72N2O12S2\/c1-49-21-17-31(55)25-29(49)5-7-33-35-9-11-41(51(35,3)23-19-37(33)49)65-45(59)15-13-43(57)53-39(47(61)62)27-67-68-28-40(48(63)64)54-44(58)14-16-46(60)66-42-12-10-36-34-8-6-30-26-32(56)18-22-50(30,2)38(34)20-24-52(36,42)4\/h25-26,33-42H,5-24,27-28H2,1-4H3,(H,53,57)(H,54,58)(H,61,62)(H,63,64)\/t33?,34?,35?,36?,37?,38?,39?,40?,41?,42?,49-,50-,51-,52-\/m0\/s1
InChIKey : JQFBOUYGPMDHND-BCYKZMCHSA-N
Other name(s) :
Target
Families : RLC14 ligand of proteins in family
Epoxide_hydrolase
Protein :
human-EPHX2
References (3)
| Title : A novel inhibitor of soluble epoxide hydrolase that adducts C521 is cardioprotective - Charles_2025_Redox.Biol_89_103974 |
| Author(s) : Charles RL , Fernandez-Caggiano M , Rudyk O , Tyson-Hirst I , Ehteramyan M , Switzer CH , Buccafusca R , Rajeeve V , Bianchi K , Morales V , Finch AJ , Eaton P |
| Ref : Redox Biol , 89 :103974 , 2025 |
| Abstract : |
| PubMedSearch : Charles_2025_Redox.Biol_89_103974 |
| PubMedID: 41406572 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : A novel inhibitor of soluble epoxide hydrolase that adducts C521 is cardioprotective - Charles_2025_Redox.Biol_89_103974 |
| Author(s) : Charles RL , Fernandez-Caggiano M , Rudyk O , Tyson-Hirst I , Ehteramyan M , Switzer CH , Buccafusca R , Rajeeve V , Bianchi K , Morales V , Finch AJ , Eaton P |
| Ref : Redox Biol , 89 :103974 , 2025 |
| Abstract : |
| PubMedSearch : Charles_2025_Redox.Biol_89_103974 |
| PubMedID: 41406572 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : A novel inhibitor of soluble epoxide hydrolase that adducts C521 is cardioprotective - Charles_2025_Redox.Biol_89_103974 |
| Author(s) : Charles RL , Fernandez-Caggiano M , Rudyk O , Tyson-Hirst I , Ehteramyan M , Switzer CH , Buccafusca R , Rajeeve V , Bianchi K , Morales V , Finch AJ , Eaton P |
| Ref : Redox Biol , 89 :103974 , 2025 |
| Abstract : |
| PubMedSearch : Charles_2025_Redox.Biol_89_103974 |
| PubMedID: 41406572 |
| Gene_locus related to this paper: human-EPHX2 |