SUMO1-EIL
The small ubiquitin-like protein modifier SUMO1 interacts with an armlike structure in DPP8 DPP9, leading to allosteric activation of the peptidase. SUMO1-EIL noncompetitive Inhibitor of DPP8 and DPP9 - E67 interacting loop (EIL)
Target
Families : SUMO1-EIL ligand of proteins in family
DPP4N_Peptidase_S9
Structure :
6TRW
Protein :
human-DPP8
human-DPP9
References (2)
| Title : Aerosol-based ligand soaking of reservoir-free protein crystals - Ross_2021_J.Appl.Crystallogr_54_895 |
| Author(s) : Ross B , Krapp S , Geiss-Friedlander R , Littmann W , Huber R , Kiefersauer R |
| Ref : J Appl Crystallogr , 54 :895 , 2021 |
| Abstract : |
| PubMedSearch : Ross_2021_J.Appl.Crystallogr_54_895 |
| PubMedID: 34188616 |
| Gene_locus related to this paper: human-DPP8 |
| Title : The SUMO1-E67 Interacting Loop Peptide Is an Allosteric Inhibitor of the Dipeptidyl Peptidases 8 and 9 - Pilla_2013_J.Biol.Chem_288_32787 |
| Author(s) : Pilla E , Kilisch M , Lenz C , Urlaub H , Geiss-Friedlander R |
| Ref : Journal of Biological Chemistry , 288 :32787 , 2013 |
| Abstract : |
| PubMedSearch : Pilla_2013_J.Biol.Chem_288_32787 |
| PubMedID: 24072711 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |