Homo sapiens (Human) dipeptidyl peptidase 8 (DPP8)
DPP8 and DPP9 are cytosolic peptidases. Have dpp activity similar to dpp4. The first identified endogenous DPP9 substrate is the tumor epitope RU13442 (VPYGSFKHV). Inhibition or silencing of DPP9, but not DPP8, led to increased presentation of this antigen on MHC class I alleles to cytotoxic T-cells, linking DPP9 to the MHC class I antigen presentation pathway. Small ubiquitin-like protein modifier SUMO1 acts as an allosteric activator of DPP9. By binding to an armlike motif in DPP9\; DPP9 functions as an endogenous inhibitor of NLRP1 inflammasome. DPP9 interacts with a unique autoproteolytic domain (Function to Find Domain (FIIND)) found in NLRP1 and CARD8. Previously called DRP1 Qi et al || . Has dpp activity as dpp4 || . Q7Z4D3 mstp135 very short sequence with some diff in N-term ?!! Q7Z4C8 mstp141 Q7Z4E1 mstp097
Family : DPP4N_Peptidase_S9
Block : X
Position in NCBI Life Tree : Homo sapiens
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N EMAAAMETEQL GVEIFETADC EENIESQDRP KLEPFYVERY SWSQLKKLLA DTRKYHGYMM AKAPHDFMFV KRNDPDGPHS DRIYYLAMSG ENRENTLFYS EIPKTINRAA VLMLSWKPLL DLFQATLDYG MYSREEELLR ERKRIGTVGI ASYDYHQGSG TFLFQAGSGI YHVKDGGPQG FTQQPLRPNL VETSCPNIRM DPKLCPADPD WIAFIHSNDI WISNIVTREE RRLTYVHNEL ANMEEDARSA GVATFVLQEE FDRYSGYWWC PKAETTPSGG KILRILYEEN DESEVEIIHV TSPMLETRRA DSFRYPKTGT ANPKVTFKMS EIMIDAEGRI IDVIDKELIQ PFEILFEGVE YIARAGWTPE GKYAWSILLD RSQTRLQIVL ISPELFIPVE DDVMERQRLI ESVPDSVTPL IIYEETTDIW INIHDIFHVF PQSHEEEIEF IFASECKTGF RHLYKITSIL KESKYKRSSG GLPAPSDFKC PIKEEIAITS GEWEVLGRHG SNIQVDEVRR LVYFEGTKDS PLEHHLYVVS YVNPGEVTRL TDRGYSHSCC ISQHCDFFIS KYSNQKNPHC VSLYKLSSPE DDPTCKTKEF WATILDSAGP LPDYTPPEIF SFESTTGFTL YGMLYKPHDL QPGKKYPTVL FIYGGPQVQL VNNRFKGVKY FRLNTLASLG YVVVVIDNRG SCHRGLKFEG AFKYKMGQIE IDDQVEGLQY LASRYDFIDL DRVGIHGWSY GGYLSLMALM QRSDIFRVAI AGAPVTLWIF YDTGYTERYM GHPDQNEQGY YLGSVAMQAE KFPSEPNRLL LLHGFLDENV HFAHTSILLS FLVRAGKPYD LQIYPQERHS IRVPESGEHY ELHLLHYLQE NLGSRIAALK VI
Title : Non-Specific Inhibition of Dipeptidyl Peptidases 8\/9 by Dipeptidyl Peptidase 4 Inhibitors Negatively Affects Mesenchymal Stem Cell Differentiation - Torrecillas-Baena_2023_J.Clin.Med_12_4632 |
Author(s) : Torrecillas-Baena B , Camacho-Cardenosa M , Quesada-Gomez JM , Moreno-Moreno P , Dorado G , Galvez-Moreno M , Casado-Diaz A |
Ref : J Clin Med , 12 :4632 , 2023 |
Abstract : |
PubMedSearch : Torrecillas-Baena_2023_J.Clin.Med_12_4632 |
PubMedID: 37510747 |
Gene_locus related to this paper: human-DPP8 , human-DPP9 |
Title : A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells - Moore_2022_ACS.Chem.Biol_17_2595 |
Author(s) : Moore KP , Schwaid AG , Tudor M , Park S , Beshore DC , Converso A , Shipe WD , Anand R , Lan P , Moningka R , Rothman DM , Sun W , Chi A , Cornella-Taracido I , Adam GC , Bahnck-Teets C , Carroll SS , Fay JF , Goh SL , Lusen J , Quan S , Rodriguez S , Xu M , Andrews CL , Song C , Filzen T , Li J , Hollenstein K , Klein DJ , Lammens A , Lim UM , Fang Z , McHale C , Li Y , Lu M , Diamond TL , Howell BJ , Zuck P , Balibar CJ |
Ref : ACS Chemical Biology , 17 :2595 , 2022 |
Abstract : |
PubMedSearch : Moore_2022_ACS.Chem.Biol_17_2595 |
PubMedID: 36044633 |
Gene_locus related to this paper: human-DPP8 , human-DPP9 |
Title : Chemoproteomics-Enabled Identification of 4-Oxo-beta-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9 - Carvalho_2022_Angew.Chem.Int.Ed.Engl_61_e202210498 |
Author(s) : Carvalho LAR , Ross B , Fehr L , Bolgi O , Wohrle S , Lum KM , Podlesainski D , Vieira AC , Kiefersauer R , Felix R , Rodrigues T , Lucas SD , Gross O , Geiss-Friedlander R , Cravatt BF , Huber R , Kaiser M , Moreira R |
Ref : Angew Chem Int Ed Engl , : , 2022 |
Abstract : |
PubMedSearch : Carvalho_2022_Angew.Chem.Int.Ed.Engl_61_e202210498 |
PubMedID: 36089535 |
Gene_locus related to this paper: human-DPP8 , human-DPP9 |
Title : New insights into the role of dipeptidyl peptidase 8 and dipeptidyl peptidase 9 and their inhibitors - Cui_2022_Front.Pharmacol_13_1002871 |
Author(s) : Cui C , Tian X , Wei L , Wang Y , Wang K , Fu R |
Ref : Front Pharmacol , 13 :1002871 , 2022 |
Abstract : |
PubMedSearch : Cui_2022_Front.Pharmacol_13_1002871 |
PubMedID: 36172198 |
Gene_locus related to this paper: human-DPP8 , human-DPP9 |
Title : Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair - Bolgi_2022_EMBO.Rep__e54136 |
Author(s) : Bolgi O , Silva-Garcia M , Ross B , Pilla E , Kari V , Killisch M , Spitzner M , Stark N , Lenz C , Weiss K , Donzelli L , Gorrell MD , Grade M , Riemer J , Urlaub H , Dobbelstein M , Huber R , Geiss-Friedlander R |
Ref : EMBO Rep , :e54136 , 2022 |
Abstract : |
PubMedSearch : Bolgi_2022_EMBO.Rep__e54136 |
PubMedID: 35912982 |
Gene_locus related to this paper: human-DPP8 , human-DPP9 |
Title : Aerosol-based ligand soaking of reservoir-free protein crystals - Ross_2021_J.Appl.Crystallogr_54_895 |
Author(s) : Ross B , Krapp S , Geiss-Friedlander R , Littmann W , Huber R , Kiefersauer R |
Ref : J Appl Crystallogr , 54 :895 , 2021 |
Abstract : |
PubMedSearch : Ross_2021_J.Appl.Crystallogr_54_895 |
PubMedID: 34188616 |
Gene_locus related to this paper: human-DPP8 |
Title : Profibrotic mechanisms of DPP8 and DPP9 highly expressed in the proximal renal tubule epithelial cells - Zhang_2021_Pharmacol.Res_169_105630 |
Author(s) : Zhang Y , Li K , Li Y , Zhao W , Wang L , Chen Z , Ma X , Yao T , Wang J , Dong W , Li X , Tian X , Fu R |
Ref : Pharmacol Res , 169 :105630 , 2021 |
Abstract : |
PubMedSearch : Zhang_2021_Pharmacol.Res_169_105630 |
PubMedID: 33932609 |
Gene_locus related to this paper: human-DPP8 , human-DPP9 |
Title : Dipeptidyl peptidase 9 triggers BRCA2 degradation by the N-degron pathway to promote DNA-damage repair - Silva-Garcia_2020_Biorxiv__ |
Author(s) : Silva-Garcia M , Bolgi O , Ross B , Pilla E , Kari V , Killisch M , Stark N , Lenz C , Spitzner M , Gorrell MD , Grade M , Urlaub H , Dobbelstein M , Huber R , Geiss-Friedlander R |
Ref : Biorxiv , : , 2020 |
Abstract : |
PubMedSearch : Silva-Garcia_2020_Biorxiv__ |
PubMedID: |
Gene_locus related to this paper: human-DPP8 , human-DPP9 |
Title : Activation of the CARD8 Inflammasome Requires a Disordered Region - Chui_2020_Cell.Rep_33_108264 |
Author(s) : Chui AJ , Griswold AR , Taabazuing CY , Orth EL , Gai K , Rao SD , Ball DP , Hsiao JC , Bachovchin DA |
Ref : Cell Rep , 33 :108264 , 2020 |
Abstract : |
PubMedSearch : Chui_2020_Cell.Rep_33_108264 |
PubMedID: 33053349 |
Gene_locus related to this paper: human-DPP8 , human-DPP9 |
Title : DPP8 is a novel therapeutic target for multiple myeloma - Sato_2019_Sci.Rep_9_18094 |
Author(s) : Sato T , Tatekoshi A , Takada K , Iyama S , Kamihara Y , Jawaid P , Rehman MU , Noguchi K , Kondo T , Kajikawa S , Arita K , Wada A , Murakami J , Arai M , Yasuda I , Dang NH , Hatano R , Iwao N , Ohnuma K , Morimoto C |
Ref : Sci Rep , 9 :18094 , 2019 |
Abstract : |
PubMedSearch : Sato_2019_Sci.Rep_9_18094 |
PubMedID: 31792328 |
Gene_locus related to this paper: human-DPP8 |
Title : DPP8\/9 inhibitors are universal activators of functional NLRP1 alleles - Gai_2019_Cell.Death.Dis_10_587 |
Author(s) : Gai K , Okondo MC , Rao SD , Chui AJ , Ball DP , Johnson DC , Bachovchin DA |
Ref : Cell Death Dis , 10 :587 , 2019 |
Abstract : |
PubMedSearch : Gai_2019_Cell.Death.Dis_10_587 |
PubMedID: 31383852 |
Gene_locus related to this paper: human-DPP8 , human-DPP9 |
Title : DPP8\/DPP9 inhibition elicits canonical Nlrp1b inflammasome hallmarks in murine macrophages - de Vasconcelos_2019_Life.Sci.Alliance_2_ |
Author(s) : de Vasconcelos NM , Vliegen G , Goncalves A , De Hert E , Martin-Perez R , Van Opdenbosch N , Jallapally A , Geiss-Friedlander R , Lambeir AM , Augustyns K , Van der Veken P , De Meester I , Lamkanfi M |
Ref : Life Sciences Alliance , 2 : , 2019 |
Abstract : |
PubMedSearch : de Vasconcelos_2019_Life.Sci.Alliance_2_ |
PubMedID: 30718379 |
Gene_locus related to this paper: human-DPP8 , human-DPP9 |
Title : Expression and clinical role of the dipeptidyl peptidases DPP8 and DPP9 in ovarian carcinoma - Brunetti_2019_Virchows.Arch_474_177 |
Author(s) : Brunetti M , Holth A , Panagopoulos I , Staff AC , Micci F , Davidson B |
Ref : Virchows Arch , 474 :177 , 2019 |
Abstract : |
PubMedSearch : Brunetti_2019_Virchows.Arch_474_177 |
PubMedID: 30467600 |
Gene_locus related to this paper: human-DPP8 , human-DPP9 |
Title : Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer - Ross_2018_Proc.Natl.Acad.Sci.U.S.A_115_E1437 |
Author(s) : Ross B , Krapp S , Augustin M , Kierfersauer R , Arciniega M , Geiss-Friedlander R , Huber R |
Ref : Proc Natl Acad Sci U S A , 115 :E1437 , 2018 |
Abstract : |
PubMedSearch : Ross_2018_Proc.Natl.Acad.Sci.U.S.A_115_E1437 |
PubMedID: 29382749 |
Gene_locus related to this paper: human-DPP8 , human-DPP9 |
Title : DPP8\/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia - Johnson_2018_Nat.Med_24_1151 |
Author(s) : Johnson DC , Taabazuing CY , Okondo MC , Chui AJ , Rao SD , Brown FC , Reed C , Peguero E , de Stanchina E , Kentsis A , Bachovchin DA |
Ref : Nat Med , 24 :1151 , 2018 |
Abstract : |
PubMedSearch : Johnson_2018_Nat.Med_24_1151 |
PubMedID: 29967349 |
Gene_locus related to this paper: human-DPP8 , human-DPP9 |
Title : Inhibition of Dpp8\/9 Activates the Nlrp1b Inflammasome - Okondo_2018_Cell.Chem.Biol_25_262 |
Author(s) : Okondo MC , Rao SD , Taabazuing CY , Chui AJ , Poplawski SE , Johnson DC , Bachovchin DA |
Ref : Cell Chemical Biology , 25 :262 , 2018 |
Abstract : |
PubMedSearch : Okondo_2018_Cell.Chem.Biol_25_262 |
PubMedID: 29396289 |
Gene_locus related to this paper: human-DPP8 , human-DPP9 |
Title : Pyroptosis and Apoptosis Pathways Engage in Bidirectional Crosstalk in Monocytes and Macrophages - Taabazuing_2017_Cell.Chem.Biol_24_507 |
Author(s) : Taabazuing CY , Okondo MC , Bachovchin DA |
Ref : Cell Chemical Biology , 24 :507 , 2017 |
Abstract : |
PubMedSearch : Taabazuing_2017_Cell.Chem.Biol_24_507 |
PubMedID: 28392147 |
Gene_locus related to this paper: human-DPP8 , human-DPP9 |
Title : DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis - Okondo_2017_Nat.Chem.Biol_13_46 |
Author(s) : Okondo MC , Johnson DC , Sridharan R , Go EB , Chui AJ , Wang MS , Poplawski SE , Wu W , Liu Y , Lai JH , Sanford DG , Arciprete MO , Golub TR , Bachovchin WW , Bachovchin DA |
Ref : Nat Chemical Biology , 13 :46 , 2017 |
Abstract : |
PubMedSearch : Okondo_2017_Nat.Chem.Biol_13_46 |
PubMedID: 27820798 |
Gene_locus related to this paper: human-DPP8 , human-DPP9 |
Title : The SUMO1-E67 Interacting Loop Peptide Is an Allosteric Inhibitor of the Dipeptidyl Peptidases 8 and 9 - Pilla_2013_J.Biol.Chem_288_32787 |
Author(s) : Pilla E , Kilisch M , Lenz C , Urlaub H , Geiss-Friedlander R |
Ref : Journal of Biological Chemistry , 288 :32787 , 2013 |
Abstract : |
PubMedSearch : Pilla_2013_J.Biol.Chem_288_32787 |
PubMedID: 24072711 |
Gene_locus related to this paper: human-DPP8 , human-DPP9 |
Title : Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): is DPP8-selectivity an attainable goal? - Van Goethem_2011_J.Med.Chem_54_5737 |
Author(s) : Van Goethem S , Matheeussen V , Joossens J , Lambeir AM , Chen X , De Meester I , Haemers A , Augustyns K , Van der Veken P |
Ref : Journal of Medicinal Chemistry , 54 :5737 , 2011 |
Abstract : |
PubMedSearch : Van Goethem_2011_J.Med.Chem_54_5737 |
PubMedID: 21711053 |
Gene_locus related to this paper: human-DPP8 , human-DPP9 |
Title : Hydrophilic residues surrounding the S1 and S2 pockets contribute to dimerisation and catalysis in human dipeptidyl peptidase 8 (DP8) - Pitman_2010_Biol.Chem_391_959 |
Author(s) : Pitman MR , Menz RI , Abbott CA |
Ref : Biol Chem , 391 :959 , 2010 |
Abstract : |
PubMedSearch : Pitman_2010_Biol.Chem_391_959 |
PubMedID: 20536396 |
Gene_locus related to this paper: human-DPP8 |
Title : The in vivo expression of dipeptidyl peptidases 8 and 9 - Yu_2009_J.Histochem.Cytochem_57_1025 |
Author(s) : Yu DM , Ajami K , Gall MG , Park J , Lee CS , Evans KA , McLaughlin EA , Pitman MR , Abbott CA , McCaughan GW , Gorrell MD |
Ref : Journal of Histochemistry & Cytochemistry , 57 :1025 , 2009 |
Abstract : |
PubMedSearch : Yu_2009_J.Histochem.Cytochem_57_1025 |
PubMedID: 19581630 |
Gene_locus related to this paper: human-DPP8 , human-DPP9 |
Title : DP8 and DP9 have extra-enzymatic roles in cell adhesion, migration and apoptosis - |
Author(s) : Yu DM , Wang XM , Ajami K , McCaughan GW , Gorrell MD |
Ref : Advances in Experimental Medicine & Biology , 575 :63 , 2006 |
PubMedID: 16700509 |
Gene_locus related to this paper: human-DPP8 , human-DPP9 |
Title : Extraenzymatic functions of the dipeptidyl peptidase IV-related proteins DP8 and DP9 in cell adhesion, migration and apoptosis - Yu_2006_FEBS.J_273_2447 |
Author(s) : Yu DM , Wang XM , McCaughan GW , Gorrell MD |
Ref : Febs J , 273 :2447 , 2006 |
Abstract : |
PubMedSearch : Yu_2006_FEBS.J_273_2447 |
PubMedID: 16704418 |
Gene_locus related to this paper: human-DPP8 , human-DPP9 |
Title : Investigation of the dimer interface and substrate specificity of prolyl dipeptidase DPP8 - Lee_2006_J.Biol.Chem_281_38653 |
Author(s) : Lee HJ , Chen YS , Chou CY , Chien CH , Lin CH , Chang GG , Chen X |
Ref : Journal of Biological Chemistry , 281 :38653 , 2006 |
Abstract : |
PubMedSearch : Lee_2006_J.Biol.Chem_281_38653 |
PubMedID: 17040910 |
Gene_locus related to this paper: human-DPP8 |
Title : Novel isoindoline compounds for potent and selective inhibition of prolyl dipeptidase DPP8 - Jiaang_2005_Bioorg.Med.Chem.Lett_15_687 |
Author(s) : Jiaang WT , Chen YS , Hsu T , Wu SH , Chien CH , Chang CN , Chang SP , Lee SJ , Chen X |
Ref : Bioorganic & Medicinal Chemistry Lett , 15 :687 , 2005 |
Abstract : |
PubMedSearch : Jiaang_2005_Bioorg.Med.Chem.Lett_15_687 |
PubMedID: 15664838 |
Gene_locus related to this paper: human-DPP8 |
Title : Purification and characterization of human prolyl dipeptidase DPP8 in Sf9 insect cells - Chen_2004_Protein.Expr.Purif_35_142 |
Author(s) : Chen YS , Chien CH , Goparaju CM , Hsu JT , Liang PH , Chen X |
Ref : Protein Expr Purif , 35 :142 , 2004 |
Abstract : |
PubMedSearch : Chen_2004_Protein.Expr.Purif_35_142 |
PubMedID: 15039077 |
Gene_locus related to this paper: human-DPP8 |
Title : Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases - Qi_2003_Biochem.J_373_179 |
Author(s) : Qi SY , Riviere PJ , Trojnar J , Junien JL , Akinsanya KO |
Ref : Biochemical Journal , 373 :179 , 2003 |
Abstract : |
PubMedSearch : Qi_2003_Biochem.J_373_179 |
PubMedID: 12662155 |
Gene_locus related to this paper: human-DPP8 , human-DPP9 , human-DPP10 , mouse-dpp9 , mouse-dpp10 |
Title : Structural requirements for catalysis, expression, and dimerization in the CD26\/DPIV gene family - Ajami_2003_Biochemistry_42_694 |
Author(s) : Ajami K , Abbott CA , Obradovic M , Gysbers V , Kahne T , McCaughan GW , Gorrell MD |
Ref : Biochemistry , 42 :694 , 2003 |
Abstract : |
PubMedSearch : Ajami_2003_Biochemistry_42_694 |
PubMedID: 12534281 |
Gene_locus related to this paper: human-DPP8 , human-DPP9 |
Title : Cloning, expression and chromosomal localization of a novel human dipeptidyl peptidase (DPP) IV homolog, DPP8 - Abbott_2000_Eur.J.Biochem_267_6140 |
Author(s) : Abbott CA , Yu DM , Woollatt E , Sutherland GR , McCaughan GW , Gorrell MD |
Ref : European Journal of Biochemistry , 267 :6140 , 2000 |
Abstract : |
PubMedSearch : Abbott_2000_Eur.J.Biochem_267_6140 |
PubMedID: 11012666 |
Gene_locus related to this paper: human-DPP8 |