Spermine
Spermine is a spermidine-derived biogenic polyamine polyazaalkane found as a polycation at all pH values. Found in various tissues and organisms, it often acts as an essential growth factor in some bacterial species. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure. interactant with many enzymes
General
Type : Natural
Chemical_Nomenclature : N,N'-bis(3-aminopropyl)butane-1,4-diamine
Canonical SMILES : C(CCNCCCN)CNCCCN
InChI : InChI=1S\/C10H26N4\/c11-5-3-9-13-7-1-2-8-14-10-4-6-12\/h13-14H,1-12H2
InChIKey : PFNFFQXMRSDOHW-UHFFFAOYSA-N
Other name(s) : musculamine || neuridine || gerontine || CHEMBL23194 || CHEBI:15746 || SCHEMBL14965 || ZINC1532734
MW : 202.34
Formula : C10H26N4
CAS_number : 71-44-3
PubChem : 1103
UniChem : PFNFFQXMRSDOHW-UHFFFAOYSA-N
Target
Families : Spermine ligand of proteins in family
S9N_PREPL_Peptidase_S9
Structure :
8ONO
7YWS
7YX7
7YWZ
7OB1
Protein :
9gamm-b3vi58
References (4)
| Title : Elucidation of the Conformational Transition of Oligopeptidase B by an Integrative Approach Based on the Combination of X-ray, SAXS, and Essential Dynamics Sampling Simulation - Britikov_2022_Crystals_12_712 |
| Author(s) : Britikov VV , Timofeev VI , Petrenko DE , Britikova EV , Nikolaeva AY , Vlaskina AV , Boyko KM , Mikhailova AG , Rakitina TV |
| Ref : Crystals , 12 :712 , 2022 |
| Abstract : |
| PubMedSearch : Britikov_2022_Crystals_12_712 |
| PubMedID: |
| Gene_locus related to this paper: 9gamm-b3vi58 |
| Title : First Crystal Structure of Bacterial Oligopeptidase B in an Intermediate State: The Roles of the Hinge Region Modification and Spermine - Petrenko_2021_Biology.(Basel)_10_1021 |
| Author(s) : Petrenko DE , Timofeev VI , Britikov VV , Britikova EV , Kleymenov SY , Vlaskina AV , Kuranova IP , Mikhailova AG , Rakitina TV |
| Ref : Biology (Basel) , 10 : , 2021 |
| Abstract : |
| PubMedSearch : Petrenko_2021_Biology.(Basel)_10_1021 |
| PubMedID: 34681120 |
| Gene_locus related to this paper: 9gamm-b3vi58 |
| Title : Regulation of prolyl oligopeptidase activity in regenerating rat liver - Yamakawa_1994_Biochim.Biophys.Acta_1199_279 |
| Author(s) : Yamakawa N , Shimeno H , Soeda S , Nagamatsu A |
| Ref : Biochimica & Biophysica Acta , 1199 :279 , 1994 |
| Abstract : |
| PubMedSearch : Yamakawa_1994_Biochim.Biophys.Acta_1199_279 |
| PubMedID: 8161566 |
| Title : Effects of polyamines on proline endopeptidase activity in rat brain - Soeda_1986_J.Neurochem_46_1304 |
| Author(s) : Soeda S , Yamakawa N , Shimeno H , Nagamatsu A |
| Ref : Journal of Neurochemistry , 46 :1304 , 1986 |
| Abstract : |
| PubMedSearch : Soeda_1986_J.Neurochem_46_1304 |
| PubMedID: 3512777 |