S9N_PREPL_Peptidase_S9

Relationship

Family: S9N_PREPL_Peptidase_S9

Block: X

Parent Family: Peptidase_S9

Comment

a prolyl endopeptidase-like enzyme by name only; a (thio)esterase involved in mitochondrial respiratory chain function (Rosier et al.). PREPL Prolylendopeptidase-like. Prolyl oligopeptidase (EC 3.4.21.26) (also called post-proline cleaving enzyme). N-terminal domain is a 7-bladed beta-propeller. In contrast to PREP and oligopeptidase B, which require both amino- and carboxy-terminal sequences for activity, PREPL activity appeared to depend only on the carboxy-terminal domain. Deletion of PREPL was found in patients with hypotonia-cystinuria syndrome Parvari et al. (2001, 2005) Jaeken et al. (2006)

Database

Interpro : IPR004106 Peptidase S9A\/B\/C, oligopeptidase, N-terminal beta-propeller , IPR001375 Peptidase_S9

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF00326 Peptidase_S9 , PF02897 Peptidase_S9_N

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour / coloured with Mview
Alignment with MAFFT No colour / coloured with Mview
Dendrogram The dnd file

Structure Name Proteins
8RFB Cryo-EM structure of the R243C mutant of human Prolyl Endopeptidase-Like (PREPL) protein involved in Congenital myasthenic syndrome-22 (CMS22) human-PREPL
7OBM Crystal structure of the human Prolyl Endopeptidase-like protein short form (residues 90-727) human-PREPL
8ONO Modified oligopeptidase B from S. proteamaculans in intermediate conformation with 5 spermine molecule at 1.65 A resolution 9gamm-b3vi58
7YWS Modified oligopeptidase B from S. proteomaculans in intermediate conformation with 3 spermine molecules at 1.7 A resolution 9gamm-b3vi58
7YX7 Modified oligopeptidase B from S. proteomaculans in intermediate conformation with 1 spermine molecules at 1.7 A resolution 9gamm-b3vi58
7ZJZ Catalytically non active S532A mutant of oligopeptidase B from S. proteomaculans 9gamm-b3vi58
7YWZ Modified oligopeptidase B from S. proteomaculans in intermediate conformation with 4 spermine molecules at 1.75 A resolution 9gamm-b3vi58
7YWP Closed conformation of Oligopeptidase B from Serratia proteomaculans with covalently bound TCK 9gamm-b3vi58
7OB1 Oligopeptidase B from S. proteamaculans with modified hinge region with spermine (replaced 6TF5 on 2022-11-02) 9gamm-b3vi58
7NE4 E125A mutant of oligopeptidase B from S. proteomaculans with modified hinge region 9gamm-b3vi58
7NE5 Catalytically non active S532A mutant of oligopeptidase B from S. proteomaculans with modified hinge region 9gamm-b3vi58
7NE7 oligopeptidase B from S. proteomaculans with modified hinge region in complex with N-[(1S)-5-amino-1-(chloroacetyl)pentyl]-4-methylbenzenesulfonamide 9gamm-b3vi58
4BP8 Oligopeptidase B from Trypanosoma brucei - open form trybr-PEPTB
4BP9 Oligopeptidase B from Trypanosoma brucei with covalently bound antipain - closed form trybr-PEPTB
2XE4 Crystal Structure of Leishmania Major Oligopeptidase B leima-OPB

Gene_locus Name Species
9gamm-b3vi58 Serratia proteamaculans Oligopeptidase B opdB Serratia proteamaculans
9acto-d0yse1 Mobiluncus mulieris Putative oligopeptidase B Mobiluncus mulieris 28-1
9baci-q2bbg6 Bacillus sp. NRRL B-14911 protease II Bacillus sp. NRRL B-14911
9bact-q2yzv3 uncultured candidate division WS3 bacterium hypothetical protein uncultured candidate division WS3 bacterium
9bact-q26ea8 Flavobacteria bacterium BBFL7 endopeptidase (EC 3.4.21.83) Flavobacteria bacterium BBFL7
9eury-a5yt18 uncultured haloarchaeon Dipeptidyl aminopeptidases\/acylaminoacyl-peptidases uncultured haloarchaeon
9eury-e7qtc8 Haladaptatus paucihalophilus DX253 Prolyl oligopeptidase family protein Haladaptatus paucihalophilus DX253
9eury-e7qx29 Haladaptatus paucihalophilus DX253 Peptidase S9 prolyl oligopeptidase active site domain protein Haladaptatus paucihalophilus DX253
9flao-q1vth4 Psychroflexus torquis (strain ATCC 700755 \/ ACAM 623) putative peptidase Psychroflexus torquis ATCC 700755
9flao-q1w0e6 Psychroflexus torquis (strain ATCC 700755 \/ ACAM 623) peptidase s9, prolyl oligopeptidase active site region Psychroflexus torquis ATCC 700755
9gamm-q1zh90 Psychromonas sp. CNPT3 oligopeptidase b Psychromonas sp. CNPT3
9gamm-q2c8t1 Photobacterium sp. SKA34 putative protease Photobacterium sp. SKA34
9gamm-q3qm95 Shewanella amazonensis SB2B oligopeptidase b (EC 3.4.21.83) Shewanella amazonensis SB2B
9gamm-q33uy6 Shewanella sp. PV-4 oligopeptidase b (EC 3.4.21.83) Shewanella sp. PV-4
9gamm-q351p3 Alkalilimnicola ehrlichei MLHE-1 oligopeptidase b (EC 3.4.21.83) Alkalilimnicola ehrlichei MLHE-1
9micc-q4ndr6 Arthrobacter sp. FB24 oligopeptidase b (EC 3.4.21.83) Arthrobacter sp. FB24
mobas-q1ykc0 Aurantimonas manganoxydans SI85-9A1 protease II oligopeptidase Aurantimonas manganoxydans SI85-9A1
9rhiz-q3wm30 Mesorhizobium sp. BNC1 oligopeptidase b (EC 3.4.21.83) Mesorhizobium sp. BNC1
9sphn-q1n7g5 Sphingomonas sp. SKA58 oligopeptidase b Sphingomonas sp. SKA58
9sphn-q2n770 Erythrobacter litoralis HTCC2594 protease II Erythrobacter litoralis HTCC2594
9sphn-q3vbq9 Sphingopyxis alaskensis RB2256 oligopeptidase b (EC 3.4.21.83) Sphingopyxis alaskensis RB2256
9stra-f0wjy6 Albugo laibachii Nc14 Serine protease family S09A putative Albugo laibachii Nc14
9stra-f0wr05 Albugo laibachii Nc14 Serine protease family S09A putative Albugo laibachii Nc14
phoas-q1zwm5 Photobacterium angustum (strain S14 \/ CCUG 15956) putative protease Photobacterium angustum S14
9zzzz-q2lgy6 uncultured prokaryote 2B07 hypothetical protein uncultured prokaryote 2B07
acicj-a5g275 Acidiphilium cryptum, Acidiphilium multivorum, prolyl oligopeptidase family protein Acidiphilium cryptum JF-5
agrtu-PTRB Agrobacterium tumefaciens (strain C58 \/ ATCC 33970) protease II (agr_c_1636p) Agrobacterium tumefaciens
agrvi-q71ed9 Agrobacterium vitis (Rhizobium vitis) putative dipeptidyl aminopeptidase Agrobacterium vitis
ailme-d2gu97 Ailuropoda melanoleuca (Giant panda) Uncharacterized protein Ailuropoda melanoleuca
anasp-ALR3911 Anabaena sp., Anabaena variabilis peptidase s9, protease II Anabaena variabilis
arall-d7kfz1 Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress) Prolyl oligopeptidase family protein Arabidopsis lyrata subsp. lyrata
arall-d7kwx5 Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress) Prolyl oligopeptidase family protein Arabidopsis lyrata subsp. lyrata
arall-d7mld7 Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress) Predicted protein Arabidopsis lyrata subsp. lyrata
arath-F14I3.4 Arabidopsis thaliana (Mouse-ear cress) At1g50380 f14i3.4 protein Arabidopsis thaliana
arath-Q9FGD4 Arabidopsis thaliana (Mouse-ear cress) Prolyl oligopeptidase family protein K8A10.3 At5g66960 Arabidopsis thaliana
arath-T6L1.20 Arabidopsis thaliana (Mouse-ear cress) putative protease T6L1.20 At1g69020 Arabidopsis thaliana
auran-f0yge8 Aureococcus anophagefferens (Harmful bloom alga) Putative uncharacterized protein Aureococcus anophagefferens
azovi-q4j4i0 Azotobacter vinelandii AvOP oligopeptidase b (EC 3.4.21.83) Azotobacter vinelandii AvOP
barhe-q6g4a4 Bartonella henselae (Rochalimaea henselae) protease II Bartonella henselae
barqu-q6g142 Bartonella quintana (Rochalimaea quintana) protease II Bartonella quintana
bdeba-q6mii2 Bdellovibrio bacteriovorus ptrb protein (EC 3.4.21.83) Bdellovibrio bacteriovorus
biflo-PTRB Bifidobacterium longum, Bifidobacterium sp., protease II Bifidobacterium longum
braja-PTRB Bradyrhizobium japonicum protease II Bradyrhizobium japonicum
brasb-a5e9h9 Bradyrhizobium sp. BTAi1 oligopeptidase b (EC 3.4.21.83) Bradyrhizobium sp. BTAi1
brume-BMEI1365 Brucella melitensis, Brucella suis, Brucella abortus, ptrb protease II (EC 3.4.21.83) Brucella melitensis
canfa-e2qsb1 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein Canis lupus familiaris
capo3-e9c6v2 Capsaspora owczarzaki (strain ATCC 30864) Predicted protein Capsaspora owczarzaki
caucr-CC0936 Caulobacter crescentus prolyl oligopeptidase family protein Caulobacter crescentus
chick-q5zkl5 Gallus gallus (Chicken) hypothetical protein Gallus gallus
chlau-q3dyp3 Chloroflexus aurantiacus J-10-fl prolyl oligopeptidase, n-terminal beta-propeller Chloroflexus aurantiacus J-10-fl
chlva-e1zde0 Chlorella variabilis (Green alga) Putative uncharacterized protein Chlorella variabilis
chlva-e1zhu4 Chlorella variabilis (Green alga) Putative uncharacterized protein Chlorella variabilis
chrsl-q44hq6 Chromohalobacter salexigens DSM 3043 (and strain DSM 3043 \/ ATCC BAA-138 \/ NCIM 13768) oligopeptidase b (EC 3.4.21.83) Chromohalobacter salexigens
colp3-q47v81 Colwellia psychrerythraea (strain 34H \/ ATCC BAA-681) (Vibrio psychroerythus) protease II (EC 3.4.21.83) Colwellia psychrerythraea
colp3-q47yd5 Colwellia psychrerythraea (strain 34H \/ ATCC BAA-681) (Vibrio psychroerythus) prolyl oligopeptidase family protein (EC 3.4.21.26) Colwellia psychrerythraea
colp3-q47zp5 Colwellia psychrerythraea (strain 34H \/ ATCC BAA-681) (Vibrio psychroerythus)protease II (EC 3.4.21.83) Colwellia psychrerythraea
cordi-q6nfg5 Corynebacterium diphtheriae putative prolyl oligopeptidase Corynebacterium diphtheriae
coref-CE2486 Corynebacterium efficiens putative protease II Corynebacterium efficiens
corgl-CGL2596 Corynebacterium glutamicum (Brevibacterium flavum) protease II Corynebacterium glutamicum
corjk-q4jxf4 Corynebacterium jeikeium (strain K411) ptrb protein (EC 3.4.21.83) Corynebacterium jeikeium
dicdi-q54cl7 Dictyostelium discoideum (Slime mold) hypothetical protein Dictyostelium discoideum
dicpu-f0z822 Dictyostelium purpureum (Slime mold) Putative uncharacterized protein Dictyostelium purpureum
ecoli-ptrb Escherichia coli, Escherichia albertii, Escherichia fergusonii, Oligopeptidase B Peptidase, S9A family, protease II Escherichia coli
ectha-q2cw87 Halorhodospira halophila SL1 protease II Halorhodospira halophila SL1
ectsi-d8lfv2 Ectocarpus siliculosus (Brown alga) Putative uncharacterized protein Ectocarpus siliculosus
erwct-q6d4b7 Erwinia carotovora (subsp. atroseptica) (Pectobacterium atrosepticum) protease II (EC 3.4.21.83) Erwinia carotovora
flaj1-a5fgu1 Flavobacterium johnsoniae (strain ATCC 17061 \/ DSM 2064 \/ UW101) (Cytophaga johnsonae) oligopeptidase b (EC 3.4.21.83) Flavobacterium johnsoniae UW101
glovi-q7npc6 Gloeobacter violaceus oligopeptidase Gloeobacter violaceus
gluox-q5fsz2 Gluconobacter oxydans (Gluconobacter suboxydans) oligopeptidase b (EC 3.4.21.83) Gluconobacter oxydans
halbp-e4nra7 Halogeometricum borinquense (strain ATCC 700274 \/ DSM 11551 \/ JC 10706 \/ PR3) Dipeptidyl aminopeptidase\/acylaminoacyl peptidase Halogeometricum borinquense
hallt-b9lpi5 Halorubrum lacusprofundi (strain ATCC 49239 \/ DSM 5036 \/ JCM 8891 \/ ACAM 34) Peptidase S9 prolyl oligopeptidase active site domain protein Halorubrum lacusprofundi
hallt-b9ltp9 Halorubrum lacusprofundi (strain ATCC 49239 \/ DSM 5036 \/ JCM 8891 \/ ACAM 34) Peptidase S9 prolyl oligopeptidase active site domain protein Halorubrum lacusprofundi
halma-q5v0i4 Haloarcula marismortui (Halobacterium marismortui) hypothetical protein Haloarcula marismortui
halma-q5v5g0 Haloarcula marismortui (Halobacterium marismortui) prolyl oligopeptidase family protein Haloarcula marismortui
halmd-c7nwe5 Halomicrobium mukohataei (strain ATCC 700874 \/ DSM 12286 \/ JCM 9738 \/ NCIMB 13541) (Haloarcula mukohataei) Peptidase S9 prolyl oligopeptidase active site domain protein Halomicrobium mukohataei
halmd-c7p2d1 Halomicrobium mukohataei (strain ATCC 700874 \/ DSM 12286 \/ JCM 9738 \/ NCIMB 13541) (Haloarcula mukohataei) Peptidase S9 prolyl oligopeptidase active site domain protein Halomicrobium mukohataei
hals3-b0r3a9 Halobacterium salinarum (strain ATCC 29341 \/ DSM 671 \/ R1) Putative acylaminoacyl-peptidase Halobacterium salinarum
haltv-d2rzl4 Haloterrigena turkmenica (strain ATCC 51198 \/ DSM 5511 \/ NCIMB 13204 \/ VKM B-1734) (Halococcus turkmenicus) Peptidase S9 prolyl oligopeptidase active site domain protein Haloterrigena turkmenica
halvd-d4gug3 Haloferax volcanii (strain ATCC 29605 \/ DSM 3757 \/ JCM 8879 \/ NBR 14742 \/ NCIMB 2012 \/ VKM B-1768 \/ DS2) (Halobacterium volcanii) Prolyl oligopeptidase family protein Haloferax volcanii
halwd-q18hy1 Haloquadratum walsbyi (strain DSM 16790) Dipeptidyl aminopeptidases\/acylaminoacyl-peptidases Haloquadratum walsbyi
horvd-f2cu67 Hordeum vulgare var. distichum (Two-rowed barley) Predicted protein Hordeum vulgare var. distichum
horvd-f2eji1 Hordeum vulgare var. distichum (Two-rowed barley) Predicted protein Hordeum vulgare var. distichum
human-PREPL Homo sapiens (Human) PREPL Prolylendopeptidase-like KIAA0436 Homo sapiens
idilo-q5qzz6 Idiomarina loihiensis protease II Idiomarina loihiensis
leima-OPB Leishmania major Leishmania mexicana, Leishmania donovan, L. amazonensis, L. braziliensis, L. infantum, L. donovani, oligopeptidase B (EC 3.4.21.83) Leishmania major
leima-q4qj45 Leishmania major, Leishmania mexicana, L. donovani, L. amazonensis, L. braziliensis, L. infantum Oligopeptidase B-like protein Serine peptidase, clan sc, family s9a-like protein) Leishmania major
leixx-q6ah78 Leifsonia xyli (subsp. xyli) protease II Leifsonia xyli
macfa-ppcel Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Prolylendopeptidase-like Macaca fascicularis
maize-b6sw49 Zea mays (Maize) Protease 2 Zea mays
maize-b6u2a2 Zea mays (Maize) Protease 2 Zea mays
meslo-MLL7643 Rhizobium loti (Mesorhizobium loti) aminopeptidase Rhizobium loti
meslo-MLR6087 Rhizobium loti (Mesorhizobium loti) dipeptidyl aminopeptidase Rhizobium loti
micpc-c1mvx4 Micromonas pusilla (strain CCMP1545) (Picoplanktonic green alga) Predicted protein Micromonas pusilla
micsr-c1ec00 Micromonas sp. (strain RCC299 \/ NOUM17) (Picoplanktonic green alga) Predicted protein Micromonas sp.
monbe-a9uym3 Monosiga brevicollis (Choanoflagellate) Predicted protein Monosiga brevicollis
monbe-a9uyw1 Monosiga brevicollis (Choanoflagellate) Predicted protein Monosiga brevicollis
monbe-a9v3a5 Monosiga brevicollis (Choanoflagellate) Predicted protein Monosiga brevicollis
morla-ptrb Moraxella lacunata protease II Moraxella lacunata
mouse-Q8C167 Mus musculus (Mouse) PERLP unknown (protein for mgc:7980) mkiaa0436 Mus musculus
mycgi-a4t7k3 Mycobacterium gilvum (Mycobacterium flavescens), Mycobacterium sp., prolyl oligopeptidase, prolyl oligopeptidase, n-terminal beta-propeller Mycobacterium gilvum PYR-GCK
mycle-PTRB Mycobacterium leprae ptrb (protease II) Mycobacterium leprae
mycpa-q743h0 Mycobacterium paratuberculosis ptrba Mycobacterium paratuberculosis
mycss-q1b371 Mycobacterium sp. oligopeptidase b (EC 3.4.21.83) Mycobacterium sp. JLS
myctu-RV0782 Mycobacterium tuberculosis and Mycobacterium bovis hypothetical 60.9 kda protein cy369.26 probable protease II ptrbb (EC 3.4.21.83) RV0782 Mycobacterium tuberculosis
mycvn-q25w99 Mycobacterium vanbaalenii PYR-1 oligopeptidase b (EC 3.4.21.83) Mycobacterium vanbaalenii PYR-1
naegr-d2uyn1 Naegleria gruberi (Amoeba) Predicted protein Naegleria gruberi
naegr-d2vha2 Naegleria gruberi (Amoeba) Predicted protein Naegleria gruberi
natmm-d3syc7 Natrialba magadii (strain ATCC 43099 \/ DSM 3394 \/ NCIMB 2190 \/ MS3) (Natronobacterium magadii) Peptidase S9 prolyl oligopeptidase active site domain protein Natrialba magadii
natmm-d3syn7 Natrialba magadii (strain ATCC 43099 \/ DSM 3394 \/ NCIMB 2190 \/ MS3) (Natronobacterium magadii) Peptidase S9 prolyl oligopeptidase active site domain protein Natrialba magadii
nemve-a7skr3 Nematostella vectensis (Starlet sea anemone) Predicted protein Nematostella vectensis
nithx-q1qjc7 Nitrobacter hamburgensis (strain X14 \/ DSM 10229) oligopeptidase b (EC 3.4.21.83) Nitrobacter hamburgensis
nitwn-q3spr7 Nitrobacter winogradskyi (strain Nb-255 \/ ATCC 25391 and Nitrobacter sp. Nb-311A) peptidase s9, prolyl oligopeptidase (EC 3.4.21.83) Nitrobacter winogradskyi
nocfa-q5z2d3 Nocardia farcinica putative protease Nocardia farcinica
nocsj-a1skz6 Nocardioides sp. (strain BAA-499 \/ JS614) oligopeptidase b (EC 3.4.21.83) Nocardioides sp. JS614
novad-q2gb88 Novosphingobium aromaticivorans (strain DSM 12444) oligopeptidase b (EC 3.4.21.83) Novosphingobium aromaticivorans
oceih-OB0462 Oceanobacillus iheyensis (strain DSM 14371 \/ JCM 11309 \/ KCTC 3954 \/ HTE831) acylamino-acid-releasing enzyme Oceanobacillus iheyensis
orysa-q5z417 Oryza sativa (japonica cultivar-group and subsp. indica) putative oligopeptidase b Oryza sativa
orysa-q67uz1 Oryza sativa (japonica cultivar-group and subsp. indica) putative oligopeptidase Oryza sativa
orysa-q651z3 Oryza sativa (japonica cultivar-group and subsp. indica) protease II-like Oryza sativa
ostlu-a4s7z5 Ostreococcus lucimarinus (strain CCE9901) Predicted protein Ostreococcus lucimarinus
pelub-q4fp88 Pelagibacter ubique Candidatus Pelagibacter ubique HTCC1002 oligopeptidase b (EC 3.4.21.83) Pelagibacter ubique
perm5-c5kek0 Perkinsus marinus (strain ATCC 50983 \/ TXsc) Oligopeptidase b, putative Perkinsus marinus
phatc-b7gee0 Phaeodactylum tricornutum (strain CCAP 1055\/1) Predicted protein Phaeodactylum tricornutum
pholl-q7n3k0 Photorhabdus luminescens (subsp. laumondii) protease II (oligopeptidase b) Photorhabdus luminescens
phopr-q1yyd8 Photobacterium profundum 3TCK hypothetical protease II Photobacterium profundum 3TCK
phopr-q6lim9 Photobacterium profundum (Photobacterium sp. (strain SS9)) hypothetical protease II Photobacterium profundum
phyit-d0nj14 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Serine protease family S09A, putative Phytophthora infestans
phyit-d0nwm8 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Serine protease family S09A, putative Phytophthora infestans
phypa-a9rbi6 Physcomitrella patens subsp. patens (Moss) Predicted protein Physcomitrella patens subsp. patens
phypa-a9tsl1 Physcomitrella patens subsp. patens (Moss) Predicted protein Physcomitrella patens subsp. patens
pig-f1s5k3 Sus scrofa (Pig) Uncharacterized protein Sus scrofa
polpa-d3bsr4 Polysphondylium pallidum (Cellular slime mold) Oligopeptidase B Polysphondylium pallidum
ponpy-q5rak4 Pongo pygmaeus (Orangutan) hypothetical protein dkfzp469k171 dkfzp459d0226 dkfzp459d1630 Pongo pygmaeus
poptr-b9hef3 Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa) Prolyl endopeptidase Populus trichocarpa
poptr-b9hg83 Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa) Predicted protein Populus trichocarpa
pse14-q48lb6 Pseudomonas syringae pv. phaseolicola (strain 1448A \/ Race 6) protease II Pseudomonas syringae pv. phaseolicola
pseae-PA1304 Pseudomonas aeruginosa probable oligopeptidase Pseudomonas aeruginosa
psef5-q4kgj9 Pseudomonas fluorescens (strain Pf-5 \/ ATCC BAA-477) protease II Pseudomonas fluorescens
pseht-q3if93 Pseudoalteromonas haloplanktis (strain TAC 125) oligopeptidase (protease II) (EC 3.4.21.83) Pseudoalteromonas haloplanktis
pseht-q3ik03 Pseudoalteromonas haloplanktis (strain TAC 125) oligopeptidase, type b (EC 3.4.21.83) Pseudoalteromonas haloplanktis
psepf-q3kgg4 Pseudomonas fluorescens (strain PfO-1) oligopeptidase b (EC 3.4.21.83) Pseudomonas fluorescens
psepu-PP4583 Pseudomonas putida, peptidase, putative Pseudomonas putida
psesp-DAP Pseudomonas sp dipeptidyl aminopeptidase Pseudomonas sp.
psesy-PSPTO3911 Pseudomonas syringae (pv. tomato) protease II Pseudomonas syringae
pseu2-q4zw50 Pseudomonas syringae pv. syringae (strain B728a) oligopeptidase b (EC 3.4.21.83) Pseudomonas syringae pv. syringae
ratno-q5hza6 Rattus norvegicus (Rat) similar to riken cdna d030028o16 (predicted) Rattus norvegicus
rhiec-q2kav5 Rhizobium etli, Rhizobium leguminosarum bv. viciae, bv. trifolii, protease II protein (EC 3.4.21.83) Rhizobium etli
rhime-PTRB Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) protein (EC 3.4.21.83) Sinorhizobium meliloti
rhisn-y4qf Rhizobium sp. (strain NGR234) probable peptidase y4qf (EC 3.4.21.-) Rhizobium sp.
rhisn-y4so Rhizobium sp. (strain NGR234) probable peptidase y4so (EC 3.4.21.-) Rhizobium sp.
rhop2-q2it08 Rhodopseudomonas palustris (strain HaA2) oligopeptidase b (EC 3.4.21.83) Rhodopseudomonas palustris
rhopa-q6n9h9 Rhodopseudomonas palustris putative aminopeptidase Rhodopseudomonas palustris
rhopa-q37bq0 Rhodopseudomonas palustris BisA53 oligopeptidase b (EC 3.4.21.83) Rhodopseudomonas palustris BisA53
rhopa-q37g96 Rhodopseudomonas palustris BisB5 oligopeptidase b (EC 3.4.21.83) Rhodopseudomonas palustris BisB5
rhopb-q219p2 Rhodopseudomonas palustris (strain BisB18) oligopeptidase b (EC 3.4.21.83) Rhodopseudomonas palustris
ricco-b9rgi7 Ricinus communis (Castor bean) Oligopeptidase B, putative Ricinus communis
ricco-b9rlg6 Ricinus communis (Castor bean) Oligopeptidase B, putative Ricinus communis
ricco-b9s8p2 Ricinus communis (Castor bean) Oligopeptidase B, putative Ricinus communis
ricco-b9t4l4 Ricinus communis (Castor bean) Oligopeptidase B, putative Ricinus communis
ricco-PTRB Rickettsia conorii, Rickettsia sibirica, Rickettsia peacockii, R. felis (Rickettsia azadi) R. bellii (strain RML369-C), R. typhi, R. prowazekii, R. massiliae, R. rickettsii, R. endosymbiont of Ixodes scapularis, R. africae protease II oligopeptidase b (EC 3.4.21.83) Rickettsia conorii
salen-OPDB Salmonella enterica subsp. enterica, Salmonella typhimurium, S. arizonae, S. paratyphi, S. schwarzengrund, S. enteritidis, S. dublin, S. gallinarum, S. agona, S. heidelberg, S. newport, oligopeptidase B (EC 3.4.21.83) Salmonella enterica
sals5-f2um62 Salpingoeca rosetta Putative uncharacterized protein Salpingoeca rosetta
selml-d8rpr1 Selaginella moellendorffii (Spikemoss) Putative uncharacterized protein Selaginella moellendorffii
selml-d8rpy0 Selaginella moellendorffii (Spikemoss) Putative uncharacterized protein Selaginella moellendorffii
selml-d8rzp6 Selaginella moellendorffii (Spikemoss) Putative uncharacterized protein Selaginella moellendorffii
selml-d8rzy7 Selaginella moellendorffii (Spikemoss) Putative uncharacterized protein Selaginella moellendorffii
sheon-PTRB Shewanella oneidensis, Shewanella sp., Shewanella putrefaciens, protease II (EC 3.4.21.83) Shewanella oneidensis
shifl-PTRB Other Species: Shigella sonnei, Shigella flexneri, Shigella dysenteriae protease II Shigella flexneri
sodgm-q2nth7 Sodalis glossinidius (strain morsitans) protease II Sodalis glossinidius
solue-q020h3 Solibacter usitatus (strain Ellin6076) oligopeptidase b precursor (EC 3.4.21.83) Solibacter usitatus Ellin6076
sorbi-c5x290 Sorghum bicolor (Sorghum) (Sorghum vulgare) Putative uncharacterized protein Sb02g026420 Sorghum bicolor
sorbi-c5x345 Sorghum bicolor (Sorghum) (Sorghum vulgare) Putative uncharacterized protein Sb02g027475 Sorghum bicolor
sorbi-c5z2m6 Sorghum bicolor (Sorghum) (Sorghum vulgare) Putative uncharacterized protein Sb10g031180 Sorghum bicolor
tetts-q246d1 Tetrahymena thermophila SB210 prolyl oligopeptidase family protein Tetrahymena thermophila SB210
thaps-b8bq57 Thalassiosira pseudonana (Marine diatom) (Cyclotella nana) Predicted protein Thalassiosira pseudonana
thaps-b8c9t6 Thalassiosira pseudonana (Marine diatom) (Cyclotella nana) Oligopeptidase Thalassiosira pseudonana
theha-e4mwx5 Thellungiella halophila (Salt cress) mRNA, clone: RTFL01-16-E02 Thellungiella halophila
trede-Q93EK3 Treponema denticola opdb protease II (EC 3.4.21.83) Treponema denticola
triad-b3scr3 Trichoplax adhaerens (Trichoplax reptans) Putative uncharacterized protein Trichoplax adhaerens
trowh-PTRB Tropheryma whipplei (strain Twist) (Whipple's bacillus) protease II (EC 3.4.21.83) Tropheryma whipplei
tryb2-q57xb0 Trypanosoma brucei , Trypanosoma brucei gambiense, oligopeptidase b protein, putative (EC 3.4.21.-) Trypanosoma brucei
trybr-PEPTB Trypanosoma brucei brucei, Trypanosoma evansi, Trypanosoma brucei gambiense, oligopeptidase b Trypanosoma brucei
trycr-q4d6h1 Trypanosoma cruzi oligopeptidase b, putative (EC 3.4.21.83) Trypanosoma cruzi
trycr-q4d786 Trypanosoma cruzi oligopeptidase b-like protein, putative Trypanosoma cruzi
trycr-Q94795 Trypanosoma cruzi peptidase A, oligopeptidase b, putative (EC 3.4.21.83) Trypanosoma cruzi
vibal-q1v593 Vibrio alginolyticus 12G01 putative protease Vibrio alginolyticus 12G01
vibal-q1vfi9 Vibrio alginolyticus 12G01 protease II Vibrio alginolyticus 12G01
vibch-VCA0063 Vibrio cholerae protease II Vibrio cholerae
vibf1-q5e0p3 Vibrio fischeri (strain ATCC 700601 \/ ES114) protease II (EC 3.4.21.83) Vibrio fischeri
vibpa-VPA0167 Vibrio parahaemolyticus putative protease Vibrio parahaemolyticus
vibpa-VPA1467 Vibrio parahaemolyticus, Vibrio alginolyticus, Vibrio sp., protease II Vibrio parahaemolyticus
vibsp-a3ulj6 Vibrio splendidus 12B01 Protease II Vibrio splendidus 12B01
vibvu-VV21548 Vibrio vulnificus protease II Vibrio vulnificus
vibvy-q7mff9 Vibrio vulnificus (strain YJ016) protease II Vibrio vulnificus
vitvi-a5ama3 Vitis vinifera (Grape) Putative uncharacterized protein Vitis vinifera
volca-d8tr92 Volvox carteri (Green alga) Putative uncharacterized protein Volvox carteri
wheat-q0wyn8 Triticum aestivum (Wheat) Oligopeptidase B Triticum aestivum
xanax-PTRB Xanthomonas axonopodis, Xanthomonas campestris, Xanthomonas oryzae, Xanthomonas fuscans, Xanthomonas vesicatoria, Xanthomonas perforans, protease II Xanthomonas axonopodis
xanp2-q26nv4 Xanthobacter sp. (strain Py2) putative aminopeptidase Xanthobacter sp.
xenla-q5u4i8 Xenopus laevis (African clawed frog) loc495490 protein (fragment) Xenopus laevis
xenla-q32n48 Xenopus laevis (African clawed frog) hypothetical protein Xenopus laevis
xylfa-XF1479 Xylella fastidiosa and Xylella fastidiosa Ann-1 Xylella fastidiosa Dixon peptidase Xylella fastidiosa
yerpe-PTRB Yersinia pestis, Yersinia pseudotuberculosis, oligopeptidase b (EC 3.4.21.83) Yersinia pestis
zymmo-q5nq91 Zymomonas mobilis protease II (EC 3.4.21.83) Zymomonas mobilis

Gene_locus_frgt Name Species
brafl-c3zkm2 Branchiostoma floridae (Florida lancelet) (Amphioxus) Putative uncharacterized protein Branchiostoma floridae
chlre-a8iqu9 Chlamydomonas reinhardtii (Chlamydomonas smithii) Oligopeptidase Chlamydomonas reinhardtii
ectsi-d7ftr4 Ectocarpus siliculosus (Brown alga) Putative uncharacterized protein Ectocarpus siliculosus
neocl-f0vpn9 Neospora caninum (strain Liverpool) Putative uncharacterized protein Neospora caninum
sals5-f2ul93 Salpingoeca rosetta Putative uncharacterized protein Salpingoeca rosetta
tetng-q4sqk3 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) chromosome 17 scaf14532, whole genome shotgun sequence Tetraodon nigroviridis

Substrate Chemical Nomenclature Proteins
Z-KR-pNA benzyl N-[(2S)-6-amino-1-[[(2S)-5-(diaminomethylideneamino)-1-(4-nitroanilino)-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]carbamate 9gamm-b3vi58
Z-RR-pNA benzyl N-[5-(diaminomethylideneamino)-1-[[5-(diaminomethylideneamino)-1-(4-nitroanilino)-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate 9gamm-b3vi58
BAPNA N-[5-(diaminomethylideneamino)-1-(4-nitroanilino)-1-oxopentan-2-yl]benzamide 9gamm-b3vi58
Z-Gly-Gly-Arg-AMC benzyl N-[2-[[2-[[(2S)-5-(diaminomethylideneamino)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]carbamate
Bz-Arg-AMC N-[(2S)-5-(diaminomethylideneamino)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]benzamide
Z-Phe-Arg-AMC benzyl N-[1-[[5-(diaminomethylideneamino)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate
Z-Arg-Arg-AMC benzyl N-[5-(diaminomethylideneamino)-1-[[5-(diaminomethylideneamino)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate
Boc-Gly-Arg-Arg-AMC tert-butyl N-[2-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-2-oxoethyl]carbamate
Paranitrophenylthioacetate O-(4-nitrophenyl) ethanethioate human-PREPL

Inhibitor Chemical Nomenclature Proteins
WHP313 human-PREPL
Tosyl-L-lysine-chloromethyl-ketone N-[(3S)-7-amino-1-chloro-2-oxoheptan-3-yl]-4-methylbenzenesulfonamide entcl-PRBA    human-BCHE    9gamm-b3vi58
Z-Gly-Pro-CHN2 N-Benzyloxycarbonylglycyl-proline diazomethyl ketone
Spermine N,N'-bis(3-aminopropyl)butane-1,4-diamine 9gamm-b3vi58
Leupeptin (2S)-2-acetamido-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-4-methylpentanamide
HDFP 1-(ethoxy-fluoro-oxidophosphaniumyl)hexadecane human-PREPL
AEBSF 4-(2-aminoethyl)benzenesulfonyl fluoride pig-dpp4    leima-OPB    halo1-d0lmj0    human-FAP    myctu-ym24
Antipain 2-[[5-(diaminomethylideneamino)-1-[[1-[[5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopentan-2-yl]carbamoylamino]-3-phenylpropanoic acid trybr-PEPTB    leima-OPB    wheat-cbp02
Palmostatin-M (3S,4S)-3-decyl-4-[4-[3-(dimethylamino)propylsulfonyl]butyl]oxetan-2-one human-LYPLA1    human-LYPLA2    human-PREPL
Palmostatin-B (3S,4S)-3-decyl-4-[2-(3,4-dimethoxyphenyl)ethyl]oxetan-2-one human-ABHD16A    human-ABHD6    human-FASN    human-ABHD17A    human-ABHD17B    human-ABHD17C    human-LYPLA1    human-LYPLA2    human-PREPL
SMR000042088 1-(2-methylpropyl)-3-oxo-2,5,6,7-tetrahydrocyclopenta[c]pyridine-4-carbonitrile human-PREPL
VX-Biotin human-CTSA    human-ACHE    human-BCHE
PMSF Phenylmethylsulfonyl fluoride theet-q3ch51    emeni-q5avy9    human-ABHD10    human-PREPL    myctu-Rv1430    psefl-cxest    9bact-E40    thefu-q6a0i4    ecoli-Aes    orysj-Q10QA5    bac25-mglp    9bact-Q0GMU2    bacsu-FENB    psepu-clcd1    thema-TM0077    bacsu-RsbQ    ecoli-bioh    drome-CG9542    human-FAP    tubmm-TmEst2    human-NOTUM    cutac-e6dae5    9gamm-urc15994    9baci-EstD9    geost-est30    pholl-AntI

References (21)

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Abstract :
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Gene_locus related to this paper: human-PREPL

Title : Prolyl Endopeptidase-Like Facilitates the alpha-Synuclein Aggregation Seeding, and This Effect Is Reverted by Serine Peptidase Inhibitor PMSF - Santos_2020_Biomolecules_10_
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Abstract :
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PubMedID: 32630529
Gene_locus related to this paper: human-PREPL

Title : PREPL deficiency: delineation of the phenotype and development of a functional blood assay - Regal_2018_Genet.Med_20_109
Author(s) : Regal L , Martensson E , Maystadt I , Voermans N , Lederer D , Burlina A , Juan Fita MJ , Hoogeboom AJM , Olsson Engman M , Hollemans T , Schouten M , Meulemans S , Jonson T , Francois I , Gil Ortega D , Kamsteeg EJ , Creemers JWM
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Gene_locus related to this paper: human-PREPL

Title : The Dipeptidyl Peptidase Family, Prolyl Oligopeptidase, and Prolyl Carboxypeptidase in the Immune System and Inflammatory Disease, Including Atherosclerosis - Waumans_2015_Front.Immunol_6_387
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Title : PREPL deficiency with or without cystinuria causes a novel myasthenic syndrome - Regal_2014_Neurology_82_1254
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PubMedSearch : Regal_2014_Neurology_82_1254
PubMedID: 24610330
Gene_locus related to this paper: human-PREPL

Title : Deletion of PREPl causes growth impairment and hypotonia in mice - Lone_2014_PLoS.One_9_e89160
Author(s) : Lone AM , Leidl M , McFedries AK , Horner JW , Creemers J , Saghatelian A
Ref : PLoS ONE , 9 :e89160 , 2014
Abstract :
PubMedSearch : Lone_2014_PLoS.One_9_e89160
PubMedID: 24586561
Gene_locus related to this paper: human-PREPL

Title : Trans-Golgi network morphology and sorting is regulated by prolyl-oligopeptidase-like protein PREPL and the AP-1 complex subunit 1A - Radhakrishnan_2013_J.Cell.Sci_126_1155
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Abstract :
PubMedSearch : Radhakrishnan_2013_J.Cell.Sci_126_1155
PubMedID: 23321636
Gene_locus related to this paper: human-PREPL

Title : Cellular and ultra structural evidence for cytoskeletal localization of prolyl endopeptidase-like protein in neurons - Morawski_2013_Neurosci_242_128
Author(s) : Morawski M , Nuytens K , Juhasz T , Zeitschel U , Seeger G , Waelkens E , Regal L , Schulz I , Arendt T , Szeltner Z , Creemers J , Rossner S
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PubMedID: 23485813
Gene_locus related to this paper: human-PREPL

Title : A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors - Lone_2011_J.Am.Chem.Soc_133_11665
Author(s) : Lone AM , Bachovchin DA , Westwood DB , Speers AE , Spicer TP , Fernandez-Vega V , Chase P , Hodder PS , Rosen H , Cravatt BF , Saghatelian A
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Abstract :
PubMedSearch : Lone_2011_J.Am.Chem.Soc_133_11665
PubMedID: 21692504
Gene_locus related to this paper: human-PREPL

Title : PREPL, a prolyl endopeptidase-like enzyme by name only?--Lessons from patients - Boonen_2011_CNS.Neurol.Disord.Drug.Targets_10_355
Author(s) : Boonen K , Regal L , Jaeken J , Creemers JW
Ref : CNS Neurol Disord Drug Targets , 10 :355 , 2011
Abstract :
PubMedSearch : Boonen_2011_CNS.Neurol.Disord.Drug.Targets_10_355
PubMedID: 21222627
Gene_locus related to this paper: human-PREPL

Title : Crystal structure of Leishmania major oligopeptidase B gives insight into the enzymatic properties of a trypanosomatid virulence factor - McLuskey_2010_J.Biol.Chem_285_39249
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Abstract :
PubMedSearch : McLuskey_2010_J.Biol.Chem_285_39249
PubMedID: 20926390
Gene_locus related to this paper: leima-OPB

Title : Deletion of C2orf34, PREPL and SLC3A1 causes atypical hypotonia-cystinuria syndrome - Chabrol_2009_BMJ.Case.Rep_2009_
Author(s) : Chabrol B , Martens K , Meulemans S , Cano A , Jaeken J , Matthijs G , Creemers JW
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Abstract :
PubMedSearch : Chabrol_2009_BMJ.Case.Rep_2009_
PubMedID: 21686663

Title : Deletion of C2orf34, PREPL and SLC3A1 causes atypical hypotonia-cystinuria syndrome - Chabrol_2008_J.Med.Genet_45_314
Author(s) : Chabrol B , Martens K , Meulemans S , Cano A , Jaeken J , Matthijs G , Creemers JW
Ref : Journal of Medical Genetics , 45 :314 , 2008
Abstract :
PubMedSearch : Chabrol_2008_J.Med.Genet_45_314
PubMedID: 18234729
Gene_locus related to this paper: human-PREPL

Title : Deletion of PREPL, a gene encoding a putative serine oligopeptidase, in patients with hypotonia-cystinuria syndrome - Jaeken_2006_Am.J.Hum.Genet_78_38
Author(s) : Jaeken J , Martens K , Francois I , Eyskens F , Lecointre C , Derua R , Meulemans S , Slootstra JW , Waelkens E , de Zegher F , Creemers JW , Matthijs G
Ref : American Journal of Human Genetics , 78 :38 , 2006
Abstract :
PubMedSearch : Jaeken_2006_Am.J.Hum.Genet_78_38
PubMedID: 16385448
Gene_locus related to this paper: human-PREPL

Title : PREPL: a putative novel oligopeptidase propelled into the limelight - Martens_2006_Biol.Chem_387_879
Author(s) : Martens K , Derua R , Meulemans S , Waelkens E , Jaeken J , Matthijs G , Creemers JW
Ref : Biol Chem , 387 :879 , 2006
Abstract :
PubMedSearch : Martens_2006_Biol.Chem_387_879
PubMedID: 16913837
Gene_locus related to this paper: human-PREPL

Title : Oligopeptidase B from Trypanosoma evansi. A parasite peptidase that inactivates atrial natriuretic factor in the bloodstream of infected hosts - Morty_2005_J.Biol.Chem_280_10925
Author(s) : Morty RE , Pelle R , Vadasz I , Uzcanga GL , Seeger W , Bubis J
Ref : Journal of Biological Chemistry , 280 :10925 , 2005
Abstract :
PubMedSearch : Morty_2005_J.Biol.Chem_280_10925
PubMedID: 15644339
Gene_locus related to this paper: trybr-PEPTB

Title : The prolyl oligopeptidase family - Polgar_2002_Cell.Mol.Life.Sci_59_349
Author(s) : Polgar L
Ref : Cell Mol Life Sciences , 59 :349 , 2002
Abstract :
PubMedSearch : Polgar_2002_Cell.Mol.Life.Sci_59_349
PubMedID: 11915948

Title : Catalysis of serine oligopeptidases is controlled by a gating filter mechanism - Fulop_2000_EMBO.Rep_1_277
Author(s) : Fulop V , Szeltner Z , Polgar L
Ref : EMBO Rep , 1 :277 , 2000
Abstract :
PubMedSearch : Fulop_2000_EMBO.Rep_1_277
PubMedID: 11256612
Gene_locus related to this paper: pig-ppce

Title : Oligopeptidase B from Trypanosoma brucei, a new member of an emerging subgroup of serine oligopeptidases - Morty_1999_J.Biol.Chem_274_26149
Author(s) : Morty RE , Lonsdale-Eccles JD , Morehead J , Caler EV , Mentele R , Auerswald EA , Coetzer TH , Andrews NW , Burleigh BA
Ref : Journal of Biological Chemistry , 274 :26149 , 1999
Abstract :
PubMedSearch : Morty_1999_J.Biol.Chem_274_26149
PubMedID: 10473566
Gene_locus related to this paper: leima-OPB , trybr-PEPTB

Title : Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis - Fulop_1998_Cell_94_161
Author(s) : Fulop V , Bocskei Z , Polgar L
Ref : Cell , 94 :161 , 1998
Abstract :
PubMedSearch : Fulop_1998_Cell_94_161
PubMedID: 9695945
Gene_locus related to this paper: pig-ppce

Title : Structural relationship between lipases and peptidases of the prolyl oligopeptidase family - Polgar_1992_FEBS.Lett_311_281
Author(s) : Polgar L
Ref : FEBS Letters , 311 :281 , 1992
Abstract :
PubMedSearch : Polgar_1992_FEBS.Lett_311_281
PubMedID: 1397329