S9N_PREPL_Peptidase_S9

Relationship

Family: S9N_PREPL_Peptidase_S9

Block: X

Parent Family: Peptidase_S9

Comment

a prolyl endopeptidase-like enzyme by name only; a (thio)esterase involved in mitochondrial respiratory chain function (Rosier et al.). PREPL Prolylendopeptidase-like. Prolyl oligopeptidase (EC 3.4.21.26) (also called post-proline cleaving enzyme). N-terminal domain is a 7-bladed beta-propeller. In contrast to PREP and oligopeptidase B, which require both amino- and carboxy-terminal sequences for activity, PREPL activity appeared to depend only on the carboxy-terminal domain. Deletion of PREPL was found in patients with hypotonia-cystinuria syndrome Parvari et al. (2001, 2005) Jaeken et al. (2006)

Database

Interpro : IPR004106 Peptidase S9A\/B\/C, oligopeptidase, N-terminal beta-propeller , IPR001375 Peptidase_S9

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF00326 Peptidase_S9 , PF02897 Peptidase_S9_N

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (15)

Genes Proteins in S9N_PREPL_Peptidase_S9 family (204)

Fragments of genes in S9N_PREPL_Peptidase_S9 family (6)

Structures in S9N_PREPL_Peptidase_S9 family (15)

Substrates in S9N_PREPL_Peptidase_S9 family (9)

Inhibitors in S9N_PREPL_Peptidase_S9 family (13)

References (21)

Title : Prolyl endopeptidase-like is a (thio)esterase involved in mitochondrial respiratory chain function - Rosier_2021_iScience_24_103460
Author(s) : Rosier K , McDevitt MT , Smet J , Floyd BJ , Verschoore M , Marcaida MJ , Bingman CA , Lemmens I , Dal Peraro M , Tavernier J , Cravatt BF , Gounko NV , Vints K , Monnens Y , Bhalla K , Aerts L , Rashan EH , Vanlander AV , Van Coster R , Regal L , Pagliarini DJ , Creemers JWM
Ref : iScience , 24 :103460 , 2021
PubMedID: 34888501
Gene_locus related to this paper: human-PREPL

Title : Prolyl Endopeptidase-Like Facilitates the alpha-Synuclein Aggregation Seeding, and This Effect Is Reverted by Serine Peptidase Inhibitor PMSF - Santos_2020_Biomolecules_10_
Author(s) : Santos GS , Oyadomari WY , Carvalho EA , Torquato RS , Oliveira V
Ref : Biomolecules , 10 : , 2020
PubMedID: 32630529
Gene_locus related to this paper: human-PREPL

Title : PREPL deficiency: delineation of the phenotype and development of a functional blood assay - Regal_2018_Genet.Med_20_109
Author(s) : Regal L , Martensson E , Maystadt I , Voermans N , Lederer D , Burlina A , Juan Fita MJ , Hoogeboom AJM , Olsson Engman M , Hollemans T , Schouten M , Meulemans S , Jonson T , Francois I , Gil Ortega D , Kamsteeg EJ , Creemers JWM
Ref : Genet Med , 20 :109 , 2018
PubMedID: 28726805
Gene_locus related to this paper: human-PREPL

Title : The Dipeptidyl Peptidase Family, Prolyl Oligopeptidase, and Prolyl Carboxypeptidase in the Immune System and Inflammatory Disease, Including Atherosclerosis - Waumans_2015_Front.Immunol_6_387
Author(s) : Waumans Y , Baerts L , Kehoe K , Lambeir AM , De Meester I
Ref : Front Immunol , 6 :387 , 2015
PubMedID: 26300881

Title : PREPL deficiency with or without cystinuria causes a novel myasthenic syndrome - Regal_2014_Neurology_82_1254
Author(s) : Regal L , Shen XM , Selcen D , Verhille C , Meulemans S , Creemers JW , Engel AG
Ref : Neurology , 82 :1254 , 2014
PubMedID: 24610330
Gene_locus related to this paper: human-PREPL

Title : Deletion of PREPl causes growth impairment and hypotonia in mice - Lone_2014_PLoS.One_9_e89160
Author(s) : Lone AM , Leidl M , McFedries AK , Horner JW , Creemers J , Saghatelian A
Ref : PLoS ONE , 9 :e89160 , 2014
PubMedID: 24586561
Gene_locus related to this paper: human-PREPL

Title : Trans-Golgi network morphology and sorting is regulated by prolyl-oligopeptidase-like protein PREPL and the AP-1 complex subunit 1A - Radhakrishnan_2013_J.Cell.Sci_126_1155
Author(s) : Radhakrishnan K , Baltes J , Creemers JW , Schu P
Ref : Journal of Cell Science , 126 :1155 , 2013
PubMedID: 23321636
Gene_locus related to this paper: human-PREPL

Title : Cellular and ultra structural evidence for cytoskeletal localization of prolyl endopeptidase-like protein in neurons - Morawski_2013_Neurosci_242_128
Author(s) : Morawski M , Nuytens K , Juhasz T , Zeitschel U , Seeger G , Waelkens E , Regal L , Schulz I , Arendt T , Szeltner Z , Creemers J , Rossner S
Ref : Neuroscience , 242 :128 , 2013
PubMedID: 23485813
Gene_locus related to this paper: human-PREPL

Title : PREPL, a prolyl endopeptidase-like enzyme by name only?--Lessons from patients - Boonen_2011_CNS.Neurol.Disord.Drug.Targets_10_355
Author(s) : Boonen K , Regal L , Jaeken J , Creemers JW
Ref : CNS Neurol Disord Drug Targets , 10 :355 , 2011
PubMedID: 21222627
Gene_locus related to this paper: human-PREPL

Title : A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors - Lone_2011_J.Am.Chem.Soc_133_11665
Author(s) : Lone AM , Bachovchin DA , Westwood DB , Speers AE , Spicer TP , Fernandez-Vega V , Chase P , Hodder PS , Rosen H , Cravatt BF , Saghatelian A
Ref : Journal of the American Chemical Society , 133 :11665 , 2011
PubMedID: 21692504
Gene_locus related to this paper: human-PREPL

Title : Crystal structure of Leishmania major oligopeptidase B gives insight into the enzymatic properties of a trypanosomatid virulence factor - McLuskey_2010_J.Biol.Chem_285_39249
Author(s) : McLuskey K , Paterson NG , Bland ND , Isaacs NW , Mottram JC
Ref : Journal of Biological Chemistry , 285 :39249 , 2010
PubMedID: 20926390
Gene_locus related to this paper: leima-OPB

Title : Deletion of C2orf34, PREPL and SLC3A1 causes atypical hypotonia-cystinuria syndrome - Chabrol_2009_BMJ.Case.Rep_2009_
Author(s) : Chabrol B , Martens K , Meulemans S , Cano A , Jaeken J , Matthijs G , Creemers JW
Ref : BMJ Case Rep , 2009 : , 2009
PubMedID: 21686663

Title : Deletion of C2orf34, PREPL and SLC3A1 causes atypical hypotonia-cystinuria syndrome - Chabrol_2008_J.Med.Genet_45_314
Author(s) : Chabrol B , Martens K , Meulemans S , Cano A , Jaeken J , Matthijs G , Creemers JW
Ref : Journal of Medical Genetics , 45 :314 , 2008
PubMedID: 18234729
Gene_locus related to this paper: human-PREPL

Title : Deletion of PREPL, a gene encoding a putative serine oligopeptidase, in patients with hypotonia-cystinuria syndrome - Jaeken_2006_Am.J.Hum.Genet_78_38
Author(s) : Jaeken J , Martens K , Francois I , Eyskens F , Lecointre C , Derua R , Meulemans S , Slootstra JW , Waelkens E , de Zegher F , Creemers JW , Matthijs G
Ref : American Journal of Human Genetics , 78 :38 , 2006
PubMedID: 16385448
Gene_locus related to this paper: human-PREPL

Title : PREPL: a putative novel oligopeptidase propelled into the limelight - Martens_2006_Biol.Chem_387_879
Author(s) : Martens K , Derua R , Meulemans S , Waelkens E , Jaeken J , Matthijs G , Creemers JW
Ref : Biol Chem , 387 :879 , 2006
PubMedID: 16913837
Gene_locus related to this paper: human-PREPL

Title : Oligopeptidase B from Trypanosoma evansi. A parasite peptidase that inactivates atrial natriuretic factor in the bloodstream of infected hosts - Morty_2005_J.Biol.Chem_280_10925
Author(s) : Morty RE , Pelle R , Vadasz I , Uzcanga GL , Seeger W , Bubis J
Ref : Journal of Biological Chemistry , 280 :10925 , 2005
PubMedID: 15644339
Gene_locus related to this paper: trybr-PEPTB

Title : The prolyl oligopeptidase family - Polgar_2002_Cell.Mol.Life.Sci_59_349
Author(s) : Polgar L
Ref : Cell Mol Life Sciences , 59 :349 , 2002
PubMedID: 11915948

Title : Catalysis of serine oligopeptidases is controlled by a gating filter mechanism - Fulop_2000_EMBO.Rep_1_277
Author(s) : Fulop V , Szeltner Z , Polgar L
Ref : EMBO Rep , 1 :277 , 2000
PubMedID: 11256612
Gene_locus related to this paper: pig-ppce

Title : Oligopeptidase B from Trypanosoma brucei, a new member of an emerging subgroup of serine oligopeptidases - Morty_1999_J.Biol.Chem_274_26149
Author(s) : Morty RE , Lonsdale-Eccles JD , Morehead J , Caler EV , Mentele R , Auerswald EA , Coetzer TH , Andrews NW , Burleigh BA
Ref : Journal of Biological Chemistry , 274 :26149 , 1999
PubMedID: 10473566
Gene_locus related to this paper: leima-OPB , trybr-PEPTB

Title : Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis - Fulop_1998_Cell_94_161
Author(s) : Fulop V , Bocskei Z , Polgar L
Ref : Cell , 94 :161 , 1998
PubMedID: 9695945
Gene_locus related to this paper: pig-ppce

Title : Structural relationship between lipases and peptidases of the prolyl oligopeptidase family - Polgar_1992_FEBS.Lett_311_281
Author(s) : Polgar L
Ref : FEBS Letters , 311 :281 , 1992
PubMedID: 1397329