1. Home
  2. Family
  3. S9N_PREPL_Peptidase_S9

S9N_PREPL_Peptidase_S9

Relationship

Family: S9N_PREPL_Peptidase_S9

Block: X

Parent Family: Peptidase_S9

Comment

a prolyl endopeptidase-like enzyme by name only; a (thio)esterase involved in mitochondrial respiratory chain function (Rosier et al.). PREPL Prolylendopeptidase-like. Prolyl oligopeptidase (EC 3.4.21.26) (also called post-proline cleaving enzyme). N-terminal domain is a 7-bladed beta-propeller. In contrast to PREP and oligopeptidase B, which require both amino- and carboxy-terminal sequences for activity, PREPL activity appeared to depend only on the carboxy-terminal domain. Deletion of PREPL was found in patients with hypotonia-cystinuria syndrome Parvari et al. 2001, Parvari et al. 2005, Jaeken et al. 2006 PREPL deficiency causes neonatal hypotonia, ptosis, neonatal feeding difficulties, childhood obesity, xerostomia, and growth hormone deficiency. Different recessive contiguous gene deletion syndromes involving PREPL and a variable combination of SLC3A1 (hypotonia-cystinuria syndrome), CAMKMT (atypical hypotonia-cystinuria syndrome), and PPM1B (2p21 deletion syndrome) have been described Regal et al. 2006

Database

Interpro : IPR004106 Peptidase S9A\/B\/C, oligopeptidase, N-terminal beta-propeller , IPR001375 Peptidase_S9

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF00326 Peptidase_S9 , PF02897 Peptidase_S9_N

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour / coloured with Mview
Alignment with MAFFT No colour / coloured with Mview
Dendrogram The dnd file

Structure Name Proteins
8RFB Cryo-EM structure of the R243C mutant of human Prolyl Endopeptidase-Like (PREPL) protein involved in Congenital myasthenic syndrome-22 (CMS22) human-PREPL
7OBM Crystal structure of the human Prolyl Endopeptidase-like protein short form (residues 90-727) human-PREPL
8ONO Modified oligopeptidase B from S. proteamaculans in intermediate conformation with 5 spermine molecule at 1.65 A resolution 9gamm-b3vi58
7YWS Modified oligopeptidase B from S. proteomaculans in intermediate conformation with 3 spermine molecules at 1.7 A resolution 9gamm-b3vi58
7YX7 Modified oligopeptidase B from S. proteomaculans in intermediate conformation with 1 spermine molecules at 1.7 A resolution 9gamm-b3vi58
7ZJZ Catalytically non active S532A mutant of oligopeptidase B from S. proteomaculans 9gamm-b3vi58
7YWZ Modified oligopeptidase B from S. proteomaculans in intermediate conformation with 4 spermine molecules at 1.75 A resolution 9gamm-b3vi58
7YWP Closed conformation of Oligopeptidase B from Serratia proteomaculans with covalently bound TCK 9gamm-b3vi58
7OB1 Oligopeptidase B from S. proteamaculans with modified hinge region with spermine (replaced 6TF5 on 2022-11-02) 9gamm-b3vi58
7NE4 E125A mutant of oligopeptidase B from S. proteomaculans with modified hinge region 9gamm-b3vi58
7NE5 Catalytically non active S532A mutant of oligopeptidase B from S. proteomaculans with modified hinge region 9gamm-b3vi58
7NE7 oligopeptidase B from S. proteomaculans with modified hinge region in complex with N-[(1S)-5-amino-1-(chloroacetyl)pentyl]-4-methylbenzenesulfonamide 9gamm-b3vi58
4BP8 Oligopeptidase B from Trypanosoma brucei - open form trybr-PEPTB
4BP9 Oligopeptidase B from Trypanosoma brucei with covalently bound antipain - closed form trybr-PEPTB
2XE4 Crystal Structure of Leishmania Major Oligopeptidase B leima-OPB

Gene_locus Name Species
9gamm-b3vi58 Serratia proteamaculans Oligopeptidase B opdB Serratia proteamaculans
9acto-d0yse1 Mobiluncus mulieris Putative oligopeptidase B Mobiluncus mulieris 28-1
9baci-q2bbg6 Bacillus sp. NRRL B-14911 protease II Bacillus sp. NRRL B-14911
9bact-q2yzv3 uncultured candidate division WS3 bacterium hypothetical protein uncultured candidate division WS3 bacterium
9bact-q26ea8 Flavobacteria bacterium BBFL7 endopeptidase (EC 3.4.21.83) Flavobacteria bacterium BBFL7
9eury-a5yt18 uncultured haloarchaeon Dipeptidyl aminopeptidases\/acylaminoacyl-peptidases uncultured haloarchaeon
9eury-e7qtc8 Haladaptatus paucihalophilus DX253 Prolyl oligopeptidase family protein Haladaptatus paucihalophilus DX253
9eury-e7qx29 Haladaptatus paucihalophilus DX253 Peptidase S9 prolyl oligopeptidase active site domain protein Haladaptatus paucihalophilus DX253
9flao-q1vth4 Psychroflexus torquis (strain ATCC 700755 \/ ACAM 623) putative peptidase Psychroflexus torquis ATCC 700755
9flao-q1w0e6 Psychroflexus torquis (strain ATCC 700755 \/ ACAM 623) peptidase s9, prolyl oligopeptidase active site region Psychroflexus torquis ATCC 700755
9gamm-q1zh90 Psychromonas sp. CNPT3 oligopeptidase b Psychromonas sp. CNPT3
9gamm-q2c8t1 Photobacterium sp. SKA34 putative protease Photobacterium sp. SKA34
9gamm-q3qm95 Shewanella amazonensis SB2B oligopeptidase b (EC 3.4.21.83) Shewanella amazonensis SB2B
9gamm-q33uy6 Shewanella sp. PV-4 oligopeptidase b (EC 3.4.21.83) Shewanella sp. PV-4
9gamm-q351p3 Alkalilimnicola ehrlichei MLHE-1 oligopeptidase b (EC 3.4.21.83) Alkalilimnicola ehrlichei MLHE-1
9micc-q4ndr6 Arthrobacter sp. FB24 oligopeptidase b (EC 3.4.21.83) Arthrobacter sp. FB24
mobas-q1ykc0 Aurantimonas manganoxydans SI85-9A1 protease II oligopeptidase Aurantimonas manganoxydans SI85-9A1
9rhiz-q3wm30 Mesorhizobium sp. BNC1 oligopeptidase b (EC 3.4.21.83) Mesorhizobium sp. BNC1
9sphn-q1n7g5 Sphingomonas sp. SKA58 oligopeptidase b Sphingomonas sp. SKA58
9sphn-q2n770 Erythrobacter litoralis HTCC2594 protease II Erythrobacter litoralis HTCC2594
9sphn-q3vbq9 Sphingopyxis alaskensis RB2256 oligopeptidase b (EC 3.4.21.83) Sphingopyxis alaskensis RB2256
9stra-f0wjy6 Albugo laibachii Nc14 Serine protease family S09A putative Albugo laibachii Nc14
9stra-f0wr05 Albugo laibachii Nc14 Serine protease family S09A putative Albugo laibachii Nc14
phoas-q1zwm5 Photobacterium angustum (strain S14 \/ CCUG 15956) putative protease Photobacterium angustum S14
9zzzz-q2lgy6 uncultured prokaryote 2B07 hypothetical protein uncultured prokaryote 2B07
acicj-a5g275 Acidiphilium cryptum, Acidiphilium multivorum, prolyl oligopeptidase family protein Acidiphilium cryptum JF-5
agrtu-PTRB Agrobacterium tumefaciens (strain C58 \/ ATCC 33970) protease II (agr_c_1636p) Agrobacterium tumefaciens
agrvi-q71ed9 Agrobacterium vitis (Rhizobium vitis) putative dipeptidyl aminopeptidase Agrobacterium vitis
ailme-d2gu97 Ailuropoda melanoleuca (Giant panda) Uncharacterized protein Ailuropoda melanoleuca
anasp-ALR3911 Anabaena sp., Anabaena variabilis peptidase s9, protease II Anabaena variabilis
arall-d7kfz1 Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress) Prolyl oligopeptidase family protein Arabidopsis lyrata subsp. lyrata
arall-d7kwx5 Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress) Prolyl oligopeptidase family protein Arabidopsis lyrata subsp. lyrata
arall-d7mld7 Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress) Predicted protein Arabidopsis lyrata subsp. lyrata
arath-F14I3.4 Arabidopsis thaliana (Mouse-ear cress) At1g50380 f14i3.4 protein Arabidopsis thaliana
arath-Q9FGD4 Arabidopsis thaliana (Mouse-ear cress) Prolyl oligopeptidase family protein K8A10.3 At5g66960 Arabidopsis thaliana
arath-T6L1.20 Arabidopsis thaliana (Mouse-ear cress) putative protease T6L1.20 At1g69020 Arabidopsis thaliana
auran-f0yge8 Aureococcus anophagefferens (Harmful bloom alga) Putative uncharacterized protein Aureococcus anophagefferens
azovi-q4j4i0 Azotobacter vinelandii AvOP oligopeptidase b (EC 3.4.21.83) Azotobacter vinelandii AvOP
barhe-q6g4a4 Bartonella henselae (Rochalimaea henselae) protease II Bartonella henselae
barqu-q6g142 Bartonella quintana (Rochalimaea quintana) protease II Bartonella quintana
bdeba-q6mii2 Bdellovibrio bacteriovorus ptrb protein (EC 3.4.21.83) Bdellovibrio bacteriovorus
biflo-PTRB Bifidobacterium longum, Bifidobacterium sp., protease II Bifidobacterium longum
braja-PTRB Bradyrhizobium japonicum protease II Bradyrhizobium japonicum
brasb-a5e9h9 Bradyrhizobium sp. BTAi1 oligopeptidase b (EC 3.4.21.83) Bradyrhizobium sp. BTAi1
brume-BMEI1365 Brucella melitensis, Brucella suis, Brucella abortus, ptrb protease II (EC 3.4.21.83) Brucella melitensis
canfa-e2qsb1 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein Canis lupus familiaris
capo3-e9c6v2 Capsaspora owczarzaki (strain ATCC 30864) Predicted protein Capsaspora owczarzaki
caucr-CC0936 Caulobacter crescentus prolyl oligopeptidase family protein Caulobacter crescentus
chick-q5zkl5 Gallus gallus (Chicken) hypothetical protein Gallus gallus
chlau-q3dyp3 Chloroflexus aurantiacus J-10-fl prolyl oligopeptidase, n-terminal beta-propeller Chloroflexus aurantiacus J-10-fl
chlva-e1zde0 Chlorella variabilis (Green alga) Putative uncharacterized protein Chlorella variabilis
chlva-e1zhu4 Chlorella variabilis (Green alga) Putative uncharacterized protein Chlorella variabilis
chrsl-q44hq6 Chromohalobacter salexigens DSM 3043 (and strain DSM 3043 \/ ATCC BAA-138 \/ NCIM 13768) oligopeptidase b (EC 3.4.21.83) Chromohalobacter salexigens
colp3-q47v81 Colwellia psychrerythraea (strain 34H \/ ATCC BAA-681) (Vibrio psychroerythus) protease II (EC 3.4.21.83) Colwellia psychrerythraea
colp3-q47yd5 Colwellia psychrerythraea (strain 34H \/ ATCC BAA-681) (Vibrio psychroerythus) prolyl oligopeptidase family protein (EC 3.4.21.26) Colwellia psychrerythraea
colp3-q47zp5 Colwellia psychrerythraea (strain 34H \/ ATCC BAA-681) (Vibrio psychroerythus)protease II (EC 3.4.21.83) Colwellia psychrerythraea
cordi-q6nfg5 Corynebacterium diphtheriae putative prolyl oligopeptidase Corynebacterium diphtheriae
coref-CE2486 Corynebacterium efficiens putative protease II Corynebacterium efficiens
corgl-CGL2596 Corynebacterium glutamicum (Brevibacterium flavum) protease II Corynebacterium glutamicum
corjk-q4jxf4 Corynebacterium jeikeium (strain K411) ptrb protein (EC 3.4.21.83) Corynebacterium jeikeium
dicdi-q54cl7 Dictyostelium discoideum (Slime mold) hypothetical protein Dictyostelium discoideum
dicpu-f0z822 Dictyostelium purpureum (Slime mold) Putative uncharacterized protein Dictyostelium purpureum
ecoli-ptrb Escherichia coli, Escherichia albertii, Escherichia fergusonii, Oligopeptidase B Peptidase, S9A family, protease II Escherichia coli
ectha-q2cw87 Halorhodospira halophila SL1 protease II Halorhodospira halophila SL1
ectsi-d8lfv2 Ectocarpus siliculosus (Brown alga) Putative uncharacterized protein Ectocarpus siliculosus
erwct-q6d4b7 Erwinia carotovora (subsp. atroseptica) (Pectobacterium atrosepticum) protease II (EC 3.4.21.83) Erwinia carotovora
flaj1-a5fgu1 Flavobacterium johnsoniae (strain ATCC 17061 \/ DSM 2064 \/ UW101) (Cytophaga johnsonae) oligopeptidase b (EC 3.4.21.83) Flavobacterium johnsoniae UW101
glovi-q7npc6 Gloeobacter violaceus oligopeptidase Gloeobacter violaceus
gluox-q5fsz2 Gluconobacter oxydans (Gluconobacter suboxydans) oligopeptidase b (EC 3.4.21.83) Gluconobacter oxydans
halbp-e4nra7 Halogeometricum borinquense (strain ATCC 700274 \/ DSM 11551 \/ JC 10706 \/ PR3) Dipeptidyl aminopeptidase\/acylaminoacyl peptidase Halogeometricum borinquense
hallt-b9lpi5 Halorubrum lacusprofundi (strain ATCC 49239 \/ DSM 5036 \/ JCM 8891 \/ ACAM 34) Peptidase S9 prolyl oligopeptidase active site domain protein Halorubrum lacusprofundi
hallt-b9ltp9 Halorubrum lacusprofundi (strain ATCC 49239 \/ DSM 5036 \/ JCM 8891 \/ ACAM 34) Peptidase S9 prolyl oligopeptidase active site domain protein Halorubrum lacusprofundi
halma-q5v0i4 Haloarcula marismortui (Halobacterium marismortui) hypothetical protein Haloarcula marismortui
halma-q5v5g0 Haloarcula marismortui (Halobacterium marismortui) prolyl oligopeptidase family protein Haloarcula marismortui
halmd-c7nwe5 Halomicrobium mukohataei (strain ATCC 700874 \/ DSM 12286 \/ JCM 9738 \/ NCIMB 13541) (Haloarcula mukohataei) Peptidase S9 prolyl oligopeptidase active site domain protein Halomicrobium mukohataei
halmd-c7p2d1 Halomicrobium mukohataei (strain ATCC 700874 \/ DSM 12286 \/ JCM 9738 \/ NCIMB 13541) (Haloarcula mukohataei) Peptidase S9 prolyl oligopeptidase active site domain protein Halomicrobium mukohataei
hals3-b0r3a9 Halobacterium salinarum (strain ATCC 29341 \/ DSM 671 \/ R1) Putative acylaminoacyl-peptidase Halobacterium salinarum
haltv-d2rzl4 Haloterrigena turkmenica (strain ATCC 51198 \/ DSM 5511 \/ NCIMB 13204 \/ VKM B-1734) (Halococcus turkmenicus) Peptidase S9 prolyl oligopeptidase active site domain protein Haloterrigena turkmenica
halvd-d4gug3 Haloferax volcanii (strain ATCC 29605 \/ DSM 3757 \/ JCM 8879 \/ NBR 14742 \/ NCIMB 2012 \/ VKM B-1768 \/ DS2) (Halobacterium volcanii) Prolyl oligopeptidase family protein Haloferax volcanii
halwd-q18hy1 Haloquadratum walsbyi (strain DSM 16790) Dipeptidyl aminopeptidases\/acylaminoacyl-peptidases Haloquadratum walsbyi
horvd-f2cu67 Hordeum vulgare var. distichum (Two-rowed barley) Predicted protein Hordeum vulgare var. distichum
horvd-f2eji1 Hordeum vulgare var. distichum (Two-rowed barley) Predicted protein Hordeum vulgare var. distichum
human-PREPL Homo sapiens (Human) PREPL Prolylendopeptidase-like KIAA0436 Homo sapiens
idilo-q5qzz6 Idiomarina loihiensis protease II Idiomarina loihiensis
leima-OPB Leishmania major Leishmania mexicana, Leishmania donovan, L. amazonensis, L. braziliensis, L. infantum, L. donovani, oligopeptidase B (EC 3.4.21.83) Leishmania major
leima-q4qj45 Leishmania major, Leishmania mexicana, L. donovani, L. amazonensis, L. braziliensis, L. infantum Oligopeptidase B-like protein Serine peptidase, clan sc, family s9a-like protein) Leishmania major
leixx-q6ah78 Leifsonia xyli (subsp. xyli) protease II Leifsonia xyli
macfa-ppcel Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Prolylendopeptidase-like Macaca fascicularis
maize-b6sw49 Zea mays (Maize) Protease 2 Zea mays
maize-b6u2a2 Zea mays (Maize) Protease 2 Zea mays
meslo-MLL7643 Rhizobium loti (Mesorhizobium loti) aminopeptidase Rhizobium loti
meslo-MLR6087 Rhizobium loti (Mesorhizobium loti) dipeptidyl aminopeptidase Rhizobium loti
micpc-c1mvx4 Micromonas pusilla (strain CCMP1545) (Picoplanktonic green alga) Predicted protein Micromonas pusilla
micsr-c1ec00 Micromonas sp. (strain RCC299 \/ NOUM17) (Picoplanktonic green alga) Predicted protein Micromonas sp.
monbe-a9uym3 Monosiga brevicollis (Choanoflagellate) Predicted protein Monosiga brevicollis
monbe-a9uyw1 Monosiga brevicollis (Choanoflagellate) Predicted protein Monosiga brevicollis
monbe-a9v3a5 Monosiga brevicollis (Choanoflagellate) Predicted protein Monosiga brevicollis
morla-ptrb Moraxella lacunata protease II Moraxella lacunata
mouse-Q8C167 Mus musculus (Mouse) PERLP unknown (protein for mgc:7980) mkiaa0436 Mus musculus
mycgi-a4t7k3 Mycobacterium gilvum (Mycobacterium flavescens), Mycobacterium sp., prolyl oligopeptidase, prolyl oligopeptidase, n-terminal beta-propeller Mycobacterium gilvum PYR-GCK
mycle-PTRB Mycobacterium leprae ptrb (protease II) Mycobacterium leprae
mycpa-q743h0 Mycobacterium paratuberculosis ptrba Mycobacterium paratuberculosis
mycss-q1b371 Mycobacterium sp. oligopeptidase b (EC 3.4.21.83) Mycobacterium sp. JLS
myctu-RV0782 Mycobacterium tuberculosis and Mycobacterium bovis hypothetical 60.9 kda protein cy369.26 probable protease II ptrbb (EC 3.4.21.83) RV0782 Mycobacterium tuberculosis
mycvn-q25w99 Mycobacterium vanbaalenii PYR-1 oligopeptidase b (EC 3.4.21.83) Mycobacterium vanbaalenii PYR-1
naegr-d2uyn1 Naegleria gruberi (Amoeba) Predicted protein Naegleria gruberi
naegr-d2vha2 Naegleria gruberi (Amoeba) Predicted protein Naegleria gruberi
natmm-d3syc7 Natrialba magadii (strain ATCC 43099 \/ DSM 3394 \/ NCIMB 2190 \/ MS3) (Natronobacterium magadii) Peptidase S9 prolyl oligopeptidase active site domain protein Natrialba magadii
natmm-d3syn7 Natrialba magadii (strain ATCC 43099 \/ DSM 3394 \/ NCIMB 2190 \/ MS3) (Natronobacterium magadii) Peptidase S9 prolyl oligopeptidase active site domain protein Natrialba magadii
nemve-a7skr3 Nematostella vectensis (Starlet sea anemone) Predicted protein Nematostella vectensis
nithx-q1qjc7 Nitrobacter hamburgensis (strain X14 \/ DSM 10229) oligopeptidase b (EC 3.4.21.83) Nitrobacter hamburgensis
nitwn-q3spr7 Nitrobacter winogradskyi (strain Nb-255 \/ ATCC 25391 and Nitrobacter sp. Nb-311A) peptidase s9, prolyl oligopeptidase (EC 3.4.21.83) Nitrobacter winogradskyi
nocfa-q5z2d3 Nocardia farcinica putative protease Nocardia farcinica
nocsj-a1skz6 Nocardioides sp. (strain BAA-499 \/ JS614) oligopeptidase b (EC 3.4.21.83) Nocardioides sp. JS614
novad-q2gb88 Novosphingobium aromaticivorans (strain DSM 12444) oligopeptidase b (EC 3.4.21.83) Novosphingobium aromaticivorans
oceih-OB0462 Oceanobacillus iheyensis (strain DSM 14371 \/ JCM 11309 \/ KCTC 3954 \/ HTE831) acylamino-acid-releasing enzyme Oceanobacillus iheyensis
orysa-q5z417 Oryza sativa (japonica cultivar-group and subsp. indica) putative oligopeptidase b Oryza sativa
orysa-q67uz1 Oryza sativa (japonica cultivar-group and subsp. indica) putative oligopeptidase Oryza sativa
orysa-q651z3 Oryza sativa (japonica cultivar-group and subsp. indica) protease II-like Oryza sativa
ostlu-a4s7z5 Ostreococcus lucimarinus (strain CCE9901) Predicted protein Ostreococcus lucimarinus
pelub-q4fp88 Pelagibacter ubique Candidatus Pelagibacter ubique HTCC1002 oligopeptidase b (EC 3.4.21.83) Pelagibacter ubique
perm5-c5kek0 Perkinsus marinus (strain ATCC 50983 \/ TXsc) Oligopeptidase b, putative Perkinsus marinus
phatc-b7gee0 Phaeodactylum tricornutum (strain CCAP 1055\/1) Predicted protein Phaeodactylum tricornutum
pholl-q7n3k0 Photorhabdus luminescens (subsp. laumondii) protease II (oligopeptidase b) Photorhabdus luminescens
phopr-q1yyd8 Photobacterium profundum 3TCK hypothetical protease II Photobacterium profundum 3TCK
phopr-q6lim9 Photobacterium profundum (Photobacterium sp. (strain SS9)) hypothetical protease II Photobacterium profundum
phyit-d0nj14 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Serine protease family S09A, putative Phytophthora infestans
phyit-d0nwm8 Phytophthora infestans (strain T30-4) (Potato late blight fungus) Serine protease family S09A, putative Phytophthora infestans
phypa-a9rbi6 Physcomitrella patens subsp. patens (Moss) Predicted protein Physcomitrella patens subsp. patens
phypa-a9tsl1 Physcomitrella patens subsp. patens (Moss) Predicted protein Physcomitrella patens subsp. patens
pig-f1s5k3 Sus scrofa (Pig) Uncharacterized protein Sus scrofa
polpa-d3bsr4 Polysphondylium pallidum (Cellular slime mold) Oligopeptidase B Polysphondylium pallidum
ponpy-q5rak4 Pongo pygmaeus (Orangutan) hypothetical protein dkfzp469k171 dkfzp459d0226 dkfzp459d1630 Pongo pygmaeus
poptr-b9hef3 Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa) Prolyl endopeptidase Populus trichocarpa
poptr-b9hg83 Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa) Predicted protein Populus trichocarpa
pse14-q48lb6 Pseudomonas syringae pv. phaseolicola (strain 1448A \/ Race 6) protease II Pseudomonas syringae pv. phaseolicola
pseae-PA1304 Pseudomonas aeruginosa probable oligopeptidase Pseudomonas aeruginosa
psef5-q4kgj9 Pseudomonas fluorescens (strain Pf-5 \/ ATCC BAA-477) protease II Pseudomonas fluorescens
pseht-q3if93 Pseudoalteromonas haloplanktis (strain TAC 125) oligopeptidase (protease II) (EC 3.4.21.83) Pseudoalteromonas haloplanktis
pseht-q3ik03 Pseudoalteromonas haloplanktis (strain TAC 125) oligopeptidase, type b (EC 3.4.21.83) Pseudoalteromonas haloplanktis
psepf-q3kgg4 Pseudomonas fluorescens (strain PfO-1) oligopeptidase b (EC 3.4.21.83) Pseudomonas fluorescens
psepu-PP4583 Pseudomonas putida, peptidase, putative Pseudomonas putida
psesp-DAP Pseudomonas sp dipeptidyl aminopeptidase Pseudomonas sp.
psesy-PSPTO3911 Pseudomonas syringae (pv. tomato) protease II Pseudomonas syringae
pseu2-q4zw50 Pseudomonas syringae pv. syringae (strain B728a) oligopeptidase b (EC 3.4.21.83) Pseudomonas syringae pv. syringae
ratno-q5hza6 Rattus norvegicus (Rat) similar to riken cdna d030028o16 (predicted) Rattus norvegicus
rhiec-q2kav5 Rhizobium etli, Rhizobium leguminosarum bv. viciae, bv. trifolii, protease II protein (EC 3.4.21.83) Rhizobium etli
rhime-PTRB Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) protein (EC 3.4.21.83) Sinorhizobium meliloti
rhisn-y4qf Rhizobium sp. (strain NGR234) probable peptidase y4qf (EC 3.4.21.-) Rhizobium sp.
rhisn-y4so Rhizobium sp. (strain NGR234) probable peptidase y4so (EC 3.4.21.-) Rhizobium sp.
rhop2-q2it08 Rhodopseudomonas palustris (strain HaA2) oligopeptidase b (EC 3.4.21.83) Rhodopseudomonas palustris
rhopa-q6n9h9 Rhodopseudomonas palustris putative aminopeptidase Rhodopseudomonas palustris
rhopa-q37bq0 Rhodopseudomonas palustris BisA53 oligopeptidase b (EC 3.4.21.83) Rhodopseudomonas palustris BisA53
rhopa-q37g96 Rhodopseudomonas palustris BisB5 oligopeptidase b (EC 3.4.21.83) Rhodopseudomonas palustris BisB5
rhopb-q219p2 Rhodopseudomonas palustris (strain BisB18) oligopeptidase b (EC 3.4.21.83) Rhodopseudomonas palustris
ricco-b9rgi7 Ricinus communis (Castor bean) Oligopeptidase B, putative Ricinus communis
ricco-b9rlg6 Ricinus communis (Castor bean) Oligopeptidase B, putative Ricinus communis
ricco-b9s8p2 Ricinus communis (Castor bean) Oligopeptidase B, putative Ricinus communis
ricco-b9t4l4 Ricinus communis (Castor bean) Oligopeptidase B, putative Ricinus communis
ricco-PTRB Rickettsia conorii, Rickettsia sibirica, Rickettsia peacockii, R. felis (Rickettsia azadi) R. bellii (strain RML369-C), R. typhi, R. prowazekii, R. massiliae, R. rickettsii, R. endosymbiont of Ixodes scapularis, R. africae protease II oligopeptidase b (EC 3.4.21.83) Rickettsia conorii
salen-OPDB Salmonella enterica subsp. enterica, Salmonella typhimurium, S. arizonae, S. paratyphi, S. schwarzengrund, S. enteritidis, S. dublin, S. gallinarum, S. agona, S. heidelberg, S. newport, oligopeptidase B (EC 3.4.21.83) Salmonella enterica
sals5-f2um62 Salpingoeca rosetta Putative uncharacterized protein Salpingoeca rosetta
selml-d8rpr1 Selaginella moellendorffii (Spikemoss) Putative uncharacterized protein Selaginella moellendorffii
selml-d8rpy0 Selaginella moellendorffii (Spikemoss) Putative uncharacterized protein Selaginella moellendorffii
selml-d8rzp6 Selaginella moellendorffii (Spikemoss) Putative uncharacterized protein Selaginella moellendorffii
selml-d8rzy7 Selaginella moellendorffii (Spikemoss) Putative uncharacterized protein Selaginella moellendorffii
sheon-PTRB Shewanella oneidensis, Shewanella sp., Shewanella putrefaciens, protease II (EC 3.4.21.83) Shewanella oneidensis
shifl-PTRB Other Species: Shigella sonnei, Shigella flexneri, Shigella dysenteriae protease II Shigella flexneri
sodgm-q2nth7 Sodalis glossinidius (strain morsitans) protease II Sodalis glossinidius
solue-q020h3 Solibacter usitatus (strain Ellin6076) oligopeptidase b precursor (EC 3.4.21.83) Solibacter usitatus Ellin6076
sorbi-c5x290 Sorghum bicolor (Sorghum) (Sorghum vulgare) Putative uncharacterized protein Sb02g026420 Sorghum bicolor
sorbi-c5x345 Sorghum bicolor (Sorghum) (Sorghum vulgare) Putative uncharacterized protein Sb02g027475 Sorghum bicolor
sorbi-c5z2m6 Sorghum bicolor (Sorghum) (Sorghum vulgare) Putative uncharacterized protein Sb10g031180 Sorghum bicolor
tetts-q246d1 Tetrahymena thermophila SB210 prolyl oligopeptidase family protein Tetrahymena thermophila SB210
thaps-b8bq57 Thalassiosira pseudonana (Marine diatom) (Cyclotella nana) Predicted protein Thalassiosira pseudonana
thaps-b8c9t6 Thalassiosira pseudonana (Marine diatom) (Cyclotella nana) Oligopeptidase Thalassiosira pseudonana
theha-e4mwx5 Thellungiella halophila (Salt cress) mRNA, clone: RTFL01-16-E02 Thellungiella halophila
trede-Q93EK3 Treponema denticola opdb protease II (EC 3.4.21.83) Treponema denticola
triad-b3scr3 Trichoplax adhaerens (Trichoplax reptans) Putative uncharacterized protein Trichoplax adhaerens
trowh-PTRB Tropheryma whipplei (strain Twist) (Whipple's bacillus) protease II (EC 3.4.21.83) Tropheryma whipplei
tryb2-q57xb0 Trypanosoma brucei , Trypanosoma brucei gambiense, oligopeptidase b protein, putative (EC 3.4.21.-) Trypanosoma brucei
trybr-PEPTB Trypanosoma brucei brucei, Trypanosoma evansi, Trypanosoma brucei gambiense, oligopeptidase b Trypanosoma brucei
trycr-q4d6h1 Trypanosoma cruzi oligopeptidase b, putative (EC 3.4.21.83) Trypanosoma cruzi
trycr-q4d786 Trypanosoma cruzi oligopeptidase b-like protein, putative Trypanosoma cruzi
trycr-Q94795 Trypanosoma cruzi peptidase A, oligopeptidase b, putative (EC 3.4.21.83) Trypanosoma cruzi
vibal-q1v593 Vibrio alginolyticus 12G01 putative protease Vibrio alginolyticus 12G01
vibal-q1vfi9 Vibrio alginolyticus 12G01 protease II Vibrio alginolyticus 12G01
vibch-VCA0063 Vibrio cholerae protease II Vibrio cholerae
vibf1-q5e0p3 Vibrio fischeri (strain ATCC 700601 \/ ES114) protease II (EC 3.4.21.83) Vibrio fischeri
vibpa-VPA0167 Vibrio parahaemolyticus putative protease Vibrio parahaemolyticus
vibpa-VPA1467 Vibrio parahaemolyticus, Vibrio alginolyticus, Vibrio sp., protease II Vibrio parahaemolyticus
vibsp-a3ulj6 Vibrio splendidus 12B01 Protease II Vibrio splendidus 12B01
vibvu-VV21548 Vibrio vulnificus protease II Vibrio vulnificus
vibvy-q7mff9 Vibrio vulnificus (strain YJ016) protease II Vibrio vulnificus
vitvi-a5ama3 Vitis vinifera (Grape) Putative uncharacterized protein Vitis vinifera
volca-d8tr92 Volvox carteri (Green alga) Putative uncharacterized protein Volvox carteri
wheat-q0wyn8 Triticum aestivum (Wheat) Oligopeptidase B Triticum aestivum
xanax-PTRB Xanthomonas axonopodis, Xanthomonas campestris, Xanthomonas oryzae, Xanthomonas fuscans, Xanthomonas vesicatoria, Xanthomonas perforans, protease II Xanthomonas axonopodis
xanp2-q26nv4 Xanthobacter sp. (strain Py2) putative aminopeptidase Xanthobacter sp.
xenla-q5u4i8 Xenopus laevis (African clawed frog) loc495490 protein (fragment) Xenopus laevis
xenla-q32n48 Xenopus laevis (African clawed frog) hypothetical protein Xenopus laevis
xylfa-XF1479 Xylella fastidiosa and Xylella fastidiosa Ann-1 Xylella fastidiosa Dixon peptidase Xylella fastidiosa
yerpe-PTRB Yersinia pestis, Yersinia pseudotuberculosis, oligopeptidase b (EC 3.4.21.83) Yersinia pestis
zymmo-q5nq91 Zymomonas mobilis protease II (EC 3.4.21.83) Zymomonas mobilis

Gene_locus_frgt Name Species
brafl-c3zkm2 Branchiostoma floridae (Florida lancelet) (Amphioxus) Putative uncharacterized protein Branchiostoma floridae
chlre-a8iqu9 Chlamydomonas reinhardtii (Chlamydomonas smithii) Oligopeptidase Chlamydomonas reinhardtii
ectsi-d7ftr4 Ectocarpus siliculosus (Brown alga) Putative uncharacterized protein Ectocarpus siliculosus
neocl-f0vpn9 Neospora caninum (strain Liverpool) Putative uncharacterized protein Neospora caninum
sals5-f2ul93 Salpingoeca rosetta Putative uncharacterized protein Salpingoeca rosetta
tetng-q4sqk3 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) chromosome 17 scaf14532, whole genome shotgun sequence Tetraodon nigroviridis

Substrate Chemical Nomenclature Proteins
Z-KR-pNA benzyl N-[(2S)-6-amino-1-[[(2S)-5-(diaminomethylideneamino)-1-(4-nitroanilino)-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]carbamate 9gamm-b3vi58
Z-RR-pNA benzyl N-[5-(diaminomethylideneamino)-1-[[5-(diaminomethylideneamino)-1-(4-nitroanilino)-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate 9gamm-b3vi58
BAPNA N-[5-(diaminomethylideneamino)-1-(4-nitroanilino)-1-oxopentan-2-yl]benzamide 9gamm-b3vi58
Z-Gly-Gly-Arg-AMC benzyl N-[2-[[2-[[(2S)-5-(diaminomethylideneamino)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]carbamate
Bz-Arg-AMC N-[(2S)-5-(diaminomethylideneamino)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]benzamide
Z-Phe-Arg-AMC benzyl N-[1-[[5-(diaminomethylideneamino)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate
Z-Arg-Arg-AMC benzyl N-[5-(diaminomethylideneamino)-1-[[5-(diaminomethylideneamino)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate
Boc-Gly-Arg-Arg-AMC tert-butyl N-[2-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-2-oxoethyl]carbamate
Paranitrophenylthioacetate O-(4-nitrophenyl) ethanethioate human-PREPL

Inhibitor Chemical Nomenclature Proteins
WHP313 human-PREPL
Tosyl-L-lysine-chloromethyl-ketone N-[(3S)-7-amino-1-chloro-2-oxoheptan-3-yl]-4-methylbenzenesulfonamide entcl-PRBA    human-BCHE    9gamm-b3vi58
Z-Gly-Pro-CHN2 N-Benzyloxycarbonylglycyl-proline diazomethyl ketone
Spermine N,N'-bis(3-aminopropyl)butane-1,4-diamine 9gamm-b3vi58
Leupeptin (2S)-2-acetamido-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-4-methylpentanamide
HDFP 1-(ethoxy-fluoro-oxidophosphaniumyl)hexadecane human-PREPL
AEBSF 4-(2-aminoethyl)benzenesulfonyl fluoride pig-dpp4    leima-OPB    halo1-d0lmj0    human-FAP    myctu-ym24
Antipain 2-[[5-(diaminomethylideneamino)-1-[[1-[[5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopentan-2-yl]carbamoylamino]-3-phenylpropanoic acid trybr-PEPTB    leima-OPB    wheat-cbp02
Palmostatin-M (3S,4S)-3-decyl-4-[4-[3-(dimethylamino)propylsulfonyl]butyl]oxetan-2-one human-LYPLA1    human-LYPLA2    human-PREPL
Palmostatin-B (3S,4S)-3-decyl-4-[2-(3,4-dimethoxyphenyl)ethyl]oxetan-2-one human-ABHD16A    human-ABHD6    human-FASN    human-ABHD17A    human-ABHD17B    human-ABHD17C    human-LYPLA1    human-LYPLA2    human-PREPL
SMR000042088 1-(2-methylpropyl)-3-oxo-2,5,6,7-tetrahydrocyclopenta[c]pyridine-4-carbonitrile human-PREPL
VX-Biotin human-CTSA    human-ACHE    human-BCHE
PMSF Phenylmethylsulfonyl fluoride theet-q3ch51    emeni-q5avy9    human-ABHD10    human-PREPL    myctu-Rv1430    psefl-cxest    9bact-E40    thefu-q6a0i4    ecoli-Aes    orysj-Q10QA5    bac25-mglp    9bact-Q0GMU2    bacsu-FENB    psepu-clcd1    thema-TM0077    bacsu-RsbQ    ecoli-bioh    drome-CG9542    human-FAP    tubmm-TmEst2    human-NOTUM    cutac-e6dae5    9gamm-urc15994    9baci-EstD9    geost-est30    pholl-AntI

References (34)

Title : Similar metabolic pathways are affected in both Congenital Myasthenic Syndrome-22 and Prader-Willi Syndrome - Bhalla_2024_Biochim.Biophys.Acta.Mol.Basis.Dis__167175
Author(s) : Bhalla K , Rosier K , Monnens Y , Meulemans S , Vervoort E , Thorrez L , Agostinis P , Meier DT , Rochtus A , Resnick JL , Creemers JWM
Ref : Biochimica & Biophysica Acta Mol Basis Dis , :167175 , 2024
Abstract :
PubMedSearch : Bhalla_2024_Biochim.Biophys.Acta.Mol.Basis.Dis__167175
PubMedID: 38626828

Title : Prolyl Endopeptidase-like Deficiency Associated with Growth Hormone Deficiency - Sayol-Torres_2023_J.Clin.Res.Pediatr.Endocrinol_15_205
Author(s) : Sayol-Torres L , Valenzuela MI , Tomasini R , Fernandez-Alvarez P , Clemente M , Yeste D
Ref : J Clin Res Pediatr Endocrinol , 15 :205 , 2023
Abstract :
PubMedSearch : Sayol-Torres_2023_J.Clin.Res.Pediatr.Endocrinol_15_205
PubMedID: 34693706
Gene_locus related to this paper: human-PREPL

Title : Clinical and Pathologic Features of Congenital Myasthenic Syndromes Caused by 35 Genes-A Comprehensive Review - Ohno_2023_Int.J.Mol.Sci_24_
Author(s) : Ohno K , Ohkawara B , Shen XM , Selcen D , Engel AG
Ref : Int J Mol Sci , 24 : , 2023
Abstract :
PubMedSearch : Ohno_2023_Int.J.Mol.Sci_24_
PubMedID: 36835142
Gene_locus related to this paper: human-PREPL

Title : Multiomics Analyses Identify Proline Endopeptidase-Like Protein As a Key Regulator of Protein Trafficking, a Pathway Underlying Alzheimer's Disease Pathogenesis - Duarte_2023_Mol.Pharmacol_104_1
Author(s) : Duarte ML , Wang M , Gomes I , Liu C , Sharma A , Fakira AK , Gupta A , Mack SM , Zhang B , Devi LA
Ref : Molecular Pharmacology , 104 :1 , 2023
Abstract :
PubMedSearch : Duarte_2023_Mol.Pharmacol_104_1
PubMedID: 37147110
Gene_locus related to this paper: human-PREPL

Title : Prolyl endopeptidase-like is a (thio)esterase involved in mitochondrial respiratory chain function - Rosier_2021_iScience_24_103460
Author(s) : Rosier K , McDevitt MT , Smet J , Floyd BJ , Verschoore M , Marcaida MJ , Bingman CA , Lemmens I , Dal Peraro M , Tavernier J , Cravatt BF , Gounko NV , Vints K , Monnens Y , Bhalla K , Aerts L , Rashan EH , Vanlander AV , Van Coster R , Regal L , Pagliarini DJ , Creemers JWM
Ref : iScience , 24 :103460 , 2021
Abstract :
PubMedSearch : Rosier_2021_iScience_24_103460
PubMedID: 34888501
Gene_locus related to this paper: human-PREPL

Title : Hypotonia-cystinuria 2p21 deletion syndrome: Intrafamilial variability of clinical expression - Towheed_2021_Ann.Clin.Transl.Neurol_8_2199
Author(s) : Towheed A , Hietanen CL , Kamath VG , Singh LN , Ho A , Engelstad K , Cornett K , Montes J , De Vivo D
Ref : Ann Clin Transl Neurol , 8 :2199 , 2021
Abstract :
PubMedSearch : Towheed_2021_Ann.Clin.Transl.Neurol_8_2199
PubMedID: 34612606
Gene_locus related to this paper: human-PREPL

Title : A Family Case of Congenital Myasthenic Syndrome-22 Induced by Different Combinations of Molecular Causes in Siblings - Shchagina_2020_Genes.(Basel)_11_821
Author(s) : Shchagina O , Bessonova L , Bychkov I , Beskorovainaya T , Poliakov A
Ref : Genes (Basel) , 11 :821 , 2020
Abstract :
PubMedSearch : Shchagina_2020_Genes.(Basel)_11_821
PubMedID: 32707643
Gene_locus related to this paper: human-PREPL

Title : Prolyl Endopeptidase-Like Facilitates the alpha-Synuclein Aggregation Seeding, and This Effect Is Reverted by Serine Peptidase Inhibitor PMSF - Santos_2020_Biomolecules_10_
Author(s) : Santos GS , Oyadomari WY , Carvalho EA , Torquato RS , Oliveira V
Ref : Biomolecules , 10 : , 2020
Abstract :
PubMedSearch : Santos_2020_Biomolecules_10_
PubMedID: 32630529
Gene_locus related to this paper: human-PREPL

Title : PREPL Deficiency: A Homozygous Splice Site PREPL Mutation in a Patient With Congenital Myasthenic Syndrome and Absence of Ovaries and Hypoplasia of Uterus - Yang_2020_Front.Genet_11_198
Author(s) : Yang Q , Hua R , Qian J , Yi S , Shen F , Zhang Q , Li M , Luo J , Fan X
Ref : Front Genet , 11 :198 , 2020
Abstract :
PubMedSearch : Yang_2020_Front.Genet_11_198
PubMedID: 32218803
Gene_locus related to this paper: human-PREPL

Title : First maternal uniparental disomy for chromosome 2 with PREPL novel frameshift mutation of congenital myasthenic syndrome 22 in an infant - Zhang_2020_Mol.Genet.Genomic.Med_8_e1144
Author(s) : Zhang P , Wu B , Lu Y , Ni Q , Liu R , Zhou W , Wang H
Ref : Mol Genet Genomic Med , 8 :e1144 , 2020
Abstract :
PubMedSearch : Zhang_2020_Mol.Genet.Genomic.Med_8_e1144
PubMedID: 31985178
Gene_locus related to this paper: human-PREPL

Title : Clinical Application of Whole Exome Sequencing to Identify Rare but Remediable Neurologic Disorders - Kim_2020_J.Clin.Med_9_3724
Author(s) : Kim MJ , Yum MS , Seo GH , Lee Y , Jang HN , Ko TS , Lee BH
Ref : J Clin Med , 9 : , 2020
Abstract :
PubMedSearch : Kim_2020_J.Clin.Med_9_3724
PubMedID: 33233562
Gene_locus related to this paper: human-PREPL

Title : Isolated PREPL deficiency associated with congenital myasthenic syndrome-22 -
Author(s) : Laugwitz L , Redler S , Buchert R , Sturm M , Zeile I , Schara U , Wieczorek D , Haack T , Distelmaier F
Ref : Klin Padiatr , 230 :281 , 2018
PubMedID: 29913539
Gene_locus related to this paper: human-PREPL

Title : The second point mutation in PREPL: a case report and literature review - Silva_2018_J.Hum.Genet_63_677
Author(s) : Silva S , Miyake N , Tapia C , Matsumoto N
Ref : J Hum Genet , 63 :677 , 2018
Abstract :
PubMedSearch : Silva_2018_J.Hum.Genet_63_677
PubMedID: 29483676
Gene_locus related to this paper: human-PREPL

Title : PREPL deficiency: delineation of the phenotype and development of a functional blood assay - Regal_2018_Genet.Med_20_109
Author(s) : Regal L , Martensson E , Maystadt I , Voermans N , Lederer D , Burlina A , Juan Fita MJ , Hoogeboom AJM , Olsson Engman M , Hollemans T , Schouten M , Meulemans S , Jonson T , Francois I , Gil Ortega D , Kamsteeg EJ , Creemers JWM
Ref : Genet Med , 20 :109 , 2018
Abstract :
PubMedSearch : Regal_2018_Genet.Med_20_109
PubMedID: 28726805
Gene_locus related to this paper: human-PREPL

Title : The Dipeptidyl Peptidase Family, Prolyl Oligopeptidase, and Prolyl Carboxypeptidase in the Immune System and Inflammatory Disease, Including Atherosclerosis - Waumans_2015_Front.Immunol_6_387
Author(s) : Waumans Y , Baerts L , Kehoe K , Lambeir AM , De Meester I
Ref : Front Immunol , 6 :387 , 2015
Abstract :
PubMedSearch : Waumans_2015_Front.Immunol_6_387
PubMedID: 26300881

Title : PREPL deficiency with or without cystinuria causes a novel myasthenic syndrome - Regal_2014_Neurology_82_1254
Author(s) : Regal L , Shen XM , Selcen D , Verhille C , Meulemans S , Creemers JW , Engel AG
Ref : Neurology , 82 :1254 , 2014
Abstract :
PubMedSearch : Regal_2014_Neurology_82_1254
PubMedID: 24610330
Gene_locus related to this paper: human-PREPL

Title : Deletion of PREPl causes growth impairment and hypotonia in mice - Lone_2014_PLoS.One_9_e89160
Author(s) : Lone AM , Leidl M , McFedries AK , Horner JW , Creemers J , Saghatelian A
Ref : PLoS ONE , 9 :e89160 , 2014
Abstract :
PubMedSearch : Lone_2014_PLoS.One_9_e89160
PubMedID: 24586561
Gene_locus related to this paper: human-PREPL

Title : Trans-Golgi network morphology and sorting is regulated by prolyl-oligopeptidase-like protein PREPL and the AP-1 complex subunit 1A - Radhakrishnan_2013_J.Cell.Sci_126_1155
Author(s) : Radhakrishnan K , Baltes J , Creemers JW , Schu P
Ref : Journal of Cell Science , 126 :1155 , 2013
Abstract :
PubMedSearch : Radhakrishnan_2013_J.Cell.Sci_126_1155
PubMedID: 23321636
Gene_locus related to this paper: human-PREPL

Title : Cellular and ultra structural evidence for cytoskeletal localization of prolyl endopeptidase-like protein in neurons - Morawski_2013_Neurosci_242_128
Author(s) : Morawski M , Nuytens K , Juhasz T , Zeitschel U , Seeger G , Waelkens E , Regal L , Schulz I , Arendt T , Szeltner Z , Creemers J , Rossner S
Ref : Neuroscience , 242 :128 , 2013
Abstract :
PubMedSearch : Morawski_2013_Neurosci_242_128
PubMedID: 23485813
Gene_locus related to this paper: human-PREPL

Title : PREPL, a prolyl endopeptidase-like enzyme by name only?--Lessons from patients - Boonen_2011_CNS.Neurol.Disord.Drug.Targets_10_355
Author(s) : Boonen K , Regal L , Jaeken J , Creemers JW
Ref : CNS Neurol Disord Drug Targets , 10 :355 , 2011
Abstract :
PubMedSearch : Boonen_2011_CNS.Neurol.Disord.Drug.Targets_10_355
PubMedID: 21222627
Gene_locus related to this paper: human-PREPL

Title : A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors - Lone_2011_J.Am.Chem.Soc_133_11665
Author(s) : Lone AM , Bachovchin DA , Westwood DB , Speers AE , Spicer TP , Fernandez-Vega V , Chase P , Hodder PS , Rosen H , Cravatt BF , Saghatelian A
Ref : Journal of the American Chemical Society , 133 :11665 , 2011
Abstract :
PubMedSearch : Lone_2011_J.Am.Chem.Soc_133_11665
PubMedID: 21692504
Gene_locus related to this paper: human-PREPL

Title : Crystal structure of Leishmania major oligopeptidase B gives insight into the enzymatic properties of a trypanosomatid virulence factor - McLuskey_2010_J.Biol.Chem_285_39249
Author(s) : McLuskey K , Paterson NG , Bland ND , Isaacs NW , Mottram JC
Ref : Journal of Biological Chemistry , 285 :39249 , 2010
Abstract :
PubMedSearch : McLuskey_2010_J.Biol.Chem_285_39249
PubMedID: 20926390
Gene_locus related to this paper: leima-OPB

Title : Deletion of C2orf34, PREPL and SLC3A1 causes atypical hypotonia-cystinuria syndrome - Chabrol_2009_BMJ.Case.Rep_2009_
Author(s) : Chabrol B , Martens K , Meulemans S , Cano A , Jaeken J , Matthijs G , Creemers JW
Ref : BMJ Case Rep , 2009 : , 2009
Abstract :
PubMedSearch : Chabrol_2009_BMJ.Case.Rep_2009_
PubMedID: 21686663

Title : Deletion of C2orf34, PREPL and SLC3A1 causes atypical hypotonia-cystinuria syndrome - Chabrol_2008_J.Med.Genet_45_314
Author(s) : Chabrol B , Martens K , Meulemans S , Cano A , Jaeken J , Matthijs G , Creemers JW
Ref : Journal of Medical Genetics , 45 :314 , 2008
Abstract :
PubMedSearch : Chabrol_2008_J.Med.Genet_45_314
PubMedID: 18234729
Gene_locus related to this paper: human-PREPL

Title : Deletion of PREPL, a gene encoding a putative serine oligopeptidase, in patients with hypotonia-cystinuria syndrome - Jaeken_2006_Am.J.Hum.Genet_78_38
Author(s) : Jaeken J , Martens K , Francois I , Eyskens F , Lecointre C , Derua R , Meulemans S , Slootstra JW , Waelkens E , de Zegher F , Creemers JW , Matthijs G
Ref : American Journal of Human Genetics , 78 :38 , 2006
Abstract :
PubMedSearch : Jaeken_2006_Am.J.Hum.Genet_78_38
PubMedID: 16385448
Gene_locus related to this paper: human-PREPL

Title : PREPL: a putative novel oligopeptidase propelled into the limelight - Martens_2006_Biol.Chem_387_879
Author(s) : Martens K , Derua R , Meulemans S , Waelkens E , Jaeken J , Matthijs G , Creemers JW
Ref : Biol Chem , 387 :879 , 2006
Abstract :
PubMedSearch : Martens_2006_Biol.Chem_387_879
PubMedID: 16913837
Gene_locus related to this paper: human-PREPL

Title : The 2p21 deletion syndrome: characterization of the transcription content - Parvari_2005_Genomics_86_195
Author(s) : Parvari R , Gonen Y , Alshafee I , Buriakovsky S , Regev K , Hershkovitz E
Ref : Genomics , 86 :195 , 2005
Abstract :
PubMedSearch : Parvari_2005_Genomics_86_195
PubMedID: 15913950
Gene_locus related to this paper: human-PREPL

Title : Oligopeptidase B from Trypanosoma evansi. A parasite peptidase that inactivates atrial natriuretic factor in the bloodstream of infected hosts - Morty_2005_J.Biol.Chem_280_10925
Author(s) : Morty RE , Pelle R , Vadasz I , Uzcanga GL , Seeger W , Bubis J
Ref : Journal of Biological Chemistry , 280 :10925 , 2005
Abstract :
PubMedSearch : Morty_2005_J.Biol.Chem_280_10925
PubMedID: 15644339
Gene_locus related to this paper: trybr-PEPTB

Title : The prolyl oligopeptidase family - Polgar_2002_Cell.Mol.Life.Sci_59_349
Author(s) : Polgar L
Ref : Cell Mol Life Sciences , 59 :349 , 2002
Abstract :
PubMedSearch : Polgar_2002_Cell.Mol.Life.Sci_59_349
PubMedID: 11915948

Title : A recessive contiguous gene deletion of chromosome 2p16 associated with cystinuria and a mitochondrial disease - Parvari_2001_Am.J.Hum.Genet_69_869
Author(s) : Parvari R , Brodyansky I , Elpeleg O , Moses S , Landau D , Hershkovitz E
Ref : American Journal of Human Genetics , 69 :869 , 2001
Abstract :
PubMedSearch : Parvari_2001_Am.J.Hum.Genet_69_869
PubMedID: 11524703
Gene_locus related to this paper: human-PREPL

Title : Catalysis of serine oligopeptidases is controlled by a gating filter mechanism - Fulop_2000_EMBO.Rep_1_277
Author(s) : Fulop V , Szeltner Z , Polgar L
Ref : EMBO Rep , 1 :277 , 2000
Abstract :
PubMedSearch : Fulop_2000_EMBO.Rep_1_277
PubMedID: 11256612
Gene_locus related to this paper: pig-ppce

Title : Oligopeptidase B from Trypanosoma brucei, a new member of an emerging subgroup of serine oligopeptidases - Morty_1999_J.Biol.Chem_274_26149
Author(s) : Morty RE , Lonsdale-Eccles JD , Morehead J , Caler EV , Mentele R , Auerswald EA , Coetzer TH , Andrews NW , Burleigh BA
Ref : Journal of Biological Chemistry , 274 :26149 , 1999
Abstract :
PubMedSearch : Morty_1999_J.Biol.Chem_274_26149
PubMedID: 10473566
Gene_locus related to this paper: leima-OPB , trybr-PEPTB

Title : Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis - Fulop_1998_Cell_94_161
Author(s) : Fulop V , Bocskei Z , Polgar L
Ref : Cell , 94 :161 , 1998
Abstract :
PubMedSearch : Fulop_1998_Cell_94_161
PubMedID: 9695945
Gene_locus related to this paper: pig-ppce

Title : Structural relationship between lipases and peptidases of the prolyl oligopeptidase family - Polgar_1992_FEBS.Lett_311_281
Author(s) : Polgar L
Ref : FEBS Letters , 311 :281 , 1992
Abstract :
PubMedSearch : Polgar_1992_FEBS.Lett_311_281
PubMedID: 1397329