TAK-802

General

Type : Piperidine

Chemical_Nomenclature : 8-[3-[1-[(3-fluorophenyl)methyl]-4-piperidinyl]-1-oxopropyl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinoline-4-one

Canonical SMILES : C1CN(CCC1CCC(=O)C2=CC3=C4C(=C2)CCN4C(=O)CC3)CC5=CC(=CC=C5)F

InChI : InChI=1S\/C26H29FN2O2\/c27-23-3-1-2-19(14-23)17-28-11-8-18(9-12-28)4-6-24(30)22-15-20-5-7-25(31)29-13-10-21(16-22)26(20)29\/h1-3,14-16,18H,4-13,17H2

InChIKey : RAYMNBAAUXRZHA-UHFFFAOYSA-N

Other name(s) : SCHEMBL4487158


MW : 420.52

Formula : C26H29FN2O2

CAS_number :

PubChem : 9888392

UniChem : RAYMNBAAUXRZHA-UHFFFAOYSA-N

Target

Families : TAK-802 ligand of proteins in family
ACHE

Protein :
human-ACHE

References (9)

Title : The effects of the concentration-dependent erythrocyte distribution of TAK-802, a potent acetylcholinesterase inhibitor, on rat pharmacokinetics - Kakehi_2016_Biopharm.Drug.Dispos_37_467
Author(s) : Kakehi M , Tagawa Y , Goto A , Kondo T , Asahi S
Ref : Biopharmaceutics & Drug Disposition , 37 :467 , 2016
Abstract :
PubMedSearch : Kakehi_2016_Biopharm.Drug.Dispos_37_467
PubMedID: 27554287

Title : Main metabolic pathways of TAK-802, a novel drug candidate for voiding dysfunction, in humans: the involvement of carbonyl reduction by 11beta-hydroxysteroid dehydrogenase 1 - Nishihara_2014_Drug.Res.(Stuttg)_64_476
Author(s) : Nishihara M , Takahashi J , Kondo T , Mouri K , Asahi S
Ref : Drug Res (Stuttg) , 64 :476 , 2014
Abstract :
PubMedSearch : Nishihara_2014_Drug.Res.(Stuttg)_64_476
PubMedID: 24357138

Title : Disposition of the new potent acetylcholinesterase inhibitor 8-[3-[1-[(3-fluorophenyl)methyl]-4-piperidiny]-1-oxopropyl]-1, 2, 5, 6-tetrahydro-4H-pyrrolo [3, 2, 1-ij] quinolin-4-one (TAK-802) in rats, dogs and monkeys - Kakehi_2013_Drug.Res.(Stuttg)_63_293
Author(s) : Kakehi M , Tagawa Y , Kondo T , Asahi S
Ref : Drug Res (Stuttg) , 63 :293 , 2013
Abstract :
PubMedSearch : Kakehi_2013_Drug.Res.(Stuttg)_63_293
PubMedID: 23585302

Title : Effects of the selective acetylcholinesterase inhibitor TAK-802 on the voiding behavior and bladder mass increase in rats with partial bladder outlet obstruction - Hashimoto_2005_J.Urol_174_1137
Author(s) : Hashimoto T , Nagabukuro H , Doi T
Ref : J Urol , 174 :1137 , 2005
Abstract :
PubMedSearch : Hashimoto_2005_J.Urol_174_1137
PubMedID: 16094081

Title : Novel acetylcholinesterase inhibitor as increasing agent on rhythmic bladder contractions: SAR of 8-{3-[1-(3-fluorobenzyl)piperidin-4-yl]propanoyl}-1,2,5,6-tetrahydro-4H-pyrrolo[3 ,2,1-ij]quinolin-4-one (TAK-802) and related compounds - Ishichi_2005_Bioorg.Med.Chem_13_1901
Author(s) : Ishichi Y , Sasaki M , Setoh M , Tsukamoto T , Miwatashi S , Nagabukuro H , Okanishi S , Imai S , Saikawa R , Doi T , Ishihara Y
Ref : Bioorganic & Medicinal Chemistry , 13 :1901 , 2005
Abstract :
PubMedSearch : Ishichi_2005_Bioorg.Med.Chem_13_1901
PubMedID: 15727846

Title : Effects of TAK-802, a novel acetylcholinesterase inhibitor, and tamsulosin, an alpha1-adrenoceptor antagonist, and their synergistic effects on the urodynamic characteristics in a guinea-pig model of functional bladder outlet obstruction - Nagabukuro_2005_BJU.Int_95_1071
Author(s) : Nagabukuro H , Hashimoto T , Iwata M , Doi T
Ref : BJU Int , 95 :1071 , 2005
Abstract :
PubMedSearch : Nagabukuro_2005_BJU.Int_95_1071
PubMedID: 15839935

Title : Differential effects of TAK-802, a selective acetylcholinesterase inhibitor, and carbamate acetylcholinesterase inhibitors on contraction of the detrusor smooth muscle of the guinea pig - Nagabukuro_2005_Life.Sci_77_3276
Author(s) : Nagabukuro H , Doi T
Ref : Life Sciences , 77 :3276 , 2005
Abstract :
PubMedSearch : Nagabukuro_2005_Life.Sci_77_3276
PubMedID: 15978636

Title : Effects of TAK-802, a novel acetylcholinesterase inhibitor, on distension-induced rhythmic bladder contractions in rats and guinea pigs - Nagabukuro_2004_Eur.J.Pharmacol_485_299
Author(s) : Nagabukuro H , Okanishi S , Imai S , Ishichi Y , Ishihara Y , Doi T
Ref : European Journal of Pharmacology , 485 :299 , 2004
Abstract :
PubMedSearch : Nagabukuro_2004_Eur.J.Pharmacol_485_299
PubMedID: 14757154

Title : Effects of TAK-802, a novel acetylcholinesterase inhibitor, and various cholinomimetics on the urodynamic characteristics in anesthetized guinea pigs - Nagabukuro_2004_Eur.J.Pharmacol_494_225
Author(s) : Nagabukuro H , Okanishi S , Doi T
Ref : European Journal of Pharmacology , 494 :225 , 2004
Abstract :
PubMedSearch : Nagabukuro_2004_Eur.J.Pharmacol_494_225
PubMedID: 15212979