Piperidine

General

Heterocyclic amine consisting of a six-membered ring containing five methylene bridges (CH2) and one amine bridge (NH). Building block for many inhibitors of enzymes
Inhibitor Main targeted enzyme familyes Type Structure
MR33317 ACHE Multitarget 5-HT-receptor-ligand Piperidine
Ezurpimtrostat Palmitoyl-protein_thioesterase Piperidine Quinoline
Lyplal1-IN-1 LYsophospholipase_carboxylesterase Piperidine Urea derivative Triazol Morpholine Pyrimidine
75J-34n DPP4N_Peptidase_S9 Piperidine Imidazole Purine Cyanide
X20419 Thioesterase Piperazine Piperidine Pyrimidine Carboxamide Indole
ADS031 Histamine-Receptor3-H3-Antagonist Multitarget Piperidine Naphthalen
CHEMBL459756 ACHE BCHE Histamine-Receptor3-H3-Antagonist Multitarget Piperidine
FUB833 ACHE BCHE Acridine Derivative of Tacrine Alkyl linked bis-ligand Histamine-Receptor3-H3-Antagonist Multitarget Piperidine
Piperidine-4-carboxamide-alkyl-tacrine-cpd16 ACHE BCHE Acridine Derivative of Tacrine Alkyl linked bis-ligand Piperidine Carboxamide
Coumarin-dimethoxyphenyl-methylpiperidine-carboxamise-cpd3b ACHE Coumarin Piperidine Carboxamide Derivative of Donepezil Chromen
Benzylpiperidin-oxoindolin-acetamide-Cpd23 Derivative of Donepezil Piperidine Indole
Indole-piperidine-amide-cpd23a ACHE Multitarget Indole Carboxamide Derivative of Donepezil BACE1-inhibitor Piperidine
SB-1448 BCHE ACHE Multitarget Derivative of Donepezil BACE1-inhibitor Piperidine
Triazole-carbonylpiperidin-diphenylazetidin-2-one-5d Monoglyceridelipase_lysophospholip Piperidine Triazol Azetidin
Benzo-triazole-carbonylpiperidin-benzodioxol-fluorophenylazetidin-2-one-5v Monoglyceridelipase_lysophospholip Benzodioxo Piperidine Triazol Azetidin
M-18C Monoglyceridelipase_lysophospholip Carboxamide Piperidine Indole
SCHEMBL3454366 Epoxide_hydrolase Urea derivative Piperidine
SCHEMBL3454366-Boc Epoxide_hydrolase Urea derivative tert-Butyl Piperidine
SCHEMBL3454366-Isobutyryl Epoxide_hydrolase Piperidine Urea derivative
Benzofuran-carbonyl-benzyloxy-piperidine-Cpd8 ACHE Benzofuran Piperidine Acaricide
J8-A34 ACHE Piperidine Sulfur Compound Sulfonamide Quinoline Derivative of Donepezil
Compound5d-Benzylpiperidine-Phenyl-oxadiazol-thiol ACHE anti-Abeta-aggregation Sulfur Compound BACE1-inhibitor Piperidine Multitarget Carboxamide Oxadiazol Derivative of Donepezil Cyanide
C4I-7QHE BCHE Acridine Alkyl linked bis-ligand Derivative of Tacrine Carboxamide Derivative of Donepezil Naphthalen Piperidine
C0I-7QHD BCHE Acridine Alkyl linked bis-ligand Derivative of Tacrine Carboxamide Derivative of Donepezil Indole Piperidine
JZP-MA-11 ABHD6-Lip Sulfur Compound PET probe Thiadiazol Piperidine Carbamate
4c2-AChE-IN-24 ACHE Sulfur Compound Multitarget Piperidine
AZ12756122 Thioesterase Sulfonamide Piperidine Cyanide Sulfur Compound
AA692 Piperidine Triazol tert-Butyl
Loperamide Carb_B_Chordata Piperidine Drug Not A\/B H target Opioid analgesic
DFAH-12 BCHE ACHE Piperidine Hydroxycinnamic-ester Multitarget Antioxidant Derivative of Donepezil
ZLWH-23 ACHE Piperidine GSK-3 kinase inhibitor Carboxamide Multitarget Indole Cyclopropyl beta-carboline
NSD1819 Monoglyceridelipase_lysophospholip Benzodioxo Piperidine Triazol Azetidin
MAGL17b Monoglyceridelipase_lysophospholip Piperidine
Lalistat-alkyne-probe Acidic_Lipase 6_AlphaBeta_hydrolase Cutinase Hormone-sensitive_lipase_like Monoglyceridelipase_lysophospholip Piperidine Lipase inhibitor Sulfur Compound Thiadiazol Alkyne ABPP-Probe
ML226 ABHD11-Acetyl_transferase Lipase_3 Triazol Piperidine
Fotagliptin DPP4N_Peptidase_S9 Gliptin Cyanide Piperidine Triazine
CHEMBL57478 Pectinacetylesterase-Notum Fragment inhibitor of Notum Piperidine Indole
3-butyl-6-benzyloxyphthalide-Mannich-base-7d ACHE Monoamine-oxidase-inhibitor Multitarget Piperidine Benzofuran
TPPU-6-Chlorotacrine-12c Epoxide_hydrolase ACHE Multitarget Derivative of Tacrine Trifluoro Piperidine Urea derivative Alkyl linked bis-ligand
Fragment-886 Pectinacetylesterase-Notum Fragment inhibitor of Notum Piperidine Pyrazole
Fragment-201 Pectinacetylesterase-Notum Fragment inhibitor of Notum Piperidine Oxadiazol
Fragment-634 Pectinacetylesterase-Notum Fragment inhibitor of Notum Cyanide Piperidine
Piperine Pectinacetylesterase-Notum Fragment inhibitor of Notum Piperidine Natural Benzodioxo
Benzothiazole-analogue-13f Epoxide_hydrolase Benzothiazol Piperidine Sulfur Compound Sulfonamide Carboxamide
FAAH_sEH_4.5 Epoxide_hydrolase Benzothiazol Piperidine Sulfur Compound Carboxamide
CHEMBL2313198 Epoxide_hydrolase Piperidine Sulfur Compound Sulfonamide Carboxamide Trifluoro
CHEMBL3233607-S0G-3WKA Epoxide_hydrolase Piperidine Pyrimidine
H0L-7D9O ACHE Inden Piperidine
H1R-7D9Q ACHE Inden Piperidine
H0R-7D9P ACHE Inden Piperidine
WAY-121898 Cholesterol_esterase Carbamate Piperidine Phenoxyphenyl
XP7-7L4U Monoglyceridelipase_lysophospholip Piperidine Pyrrolidine
SCHEMBL19421059 Monoglyceridelipase_lysophospholip Azaspiro Piperidine
SCHEMBL19834081 Monoglyceridelipase_lysophospholip Piperidine
ABC47 abh_upf0017 CGI-58_ABHD5_ABHD4 Carbamate Piperidine N-hydroxyhydantoin Phenoxyphenyl
ABC51 CGI-58_ABHD5_ABHD4 Carbamate Piperidine N-hydroxyhydantoin Phenoxyphenyl
JJH251 Carbamate Piperidine N-hydroxyhydantoin
WHP313 S9N_PREPL_Peptidase_S9 Piperidine
JJH221 Carbamate Piperidine N-hydroxyhydantoin tert-Butyloxycarbonyl tert-Butyl
ABC44 Palmitoyl-protein_thioesterase Carbamate Piperidine N-hydroxyhydantoin
DH376 Lipase_3 Piperidine Triazol Urea derivative
ML211 LYsophospholipase_carboxylesterase ABHD11-Acetyl_transferase Piperidine Triazol tert-Butyl
KT185 ABHD6-Lip Piperidine Triazol
KT203 ABHD6-Lip Piperidine Triazol
KT182 ABHD6-Lip Piperidine Triazol
Pyranone-carbamate-cpd7p BCHE Carbamate Piperidine Antioxidant
6SAM-cpd13 BCHE Multitarget Piperidine Inden Monoamine-oxidase-inhibitor Carbamate
6RUA-3a BCHE Sulfur Compound Sulfonamide Coumarin Piperidine Carboxamide Naphthalen Chromen
JU5 BCHE Coumarin Piperidine Carboxamide Naphthalen Sulfur Compound Chromen
JUB BCHE Piperidine Piperazine NBD-nitro-benzoxadiazol-fluorescent Benzoxadiazole Sulfur Compound Sulfonamide Naphthalen
75M-5T4F DPP4N_Peptidase_S9 Piperidine Quinazoline Cyanide Purine
75L-5T4E DPP4N_Peptidase_S9 Piperidine Pyrimidine Quinazoline Purine
75N-5T4B DPP4N_Peptidase_S9 Piperidine Quinazoline Purine
TUPS Epoxide_hydrolase Piperidine Urea derivative Trifluoro Sulfur Compound Sulfonamide
UW-MD-71 ACHE BCHE Cholinesterase Piperidine Quinazoline Multitarget Histamine-Receptor3-H3-Antagonist
FG1912 GSK-3 kinase inhibitor Multitarget Pyridine Piperidine Cyclopropyl Carboxamide Derivative of Donepezil
GD29 ACHE GSK-3 kinase inhibitor Multitarget Thiazole Pyridine Piperidine Cyclopropyl Carboxamide Derivative of Donepezil
Donecopride ACHE Multitarget 5-HT-receptor-ligand Derivative of Donepezil Piperidine
RS67333 ACHE Multitarget 5-HT-receptor-ligand Piperidine
Phenolic-deriv-Donecopride-4 Multitarget 5-HT-receptor-ligand Derivative of Donepezil Piperidine
Phenolic-deriv-Donecopride-20 Carbamate Multitarget 5-HT-receptor-ligand Derivative of Donepezil Piperidine
Sigma1R-ACHE-6a ACHE Multitarget 5-HT-receptor-ligand Piperidine Sigma1R Indole Derivative of Donepezil
Sigma1R-ACHE-6b ACHE Multitarget 5-HT-receptor-ligand Piperidine Sigma1R Indole Derivative of Donepezil
AS2586144 Epoxide_hydrolase Piperidine Benzoate Cyclopropyl
6F7Q-cpd11 BCHE Multitarget Antioxidant Piperidine Quinoline Metal ion chelator Inden Carboxamide
Lalistat-1 Acidic_Lipase Hormone-sensitive_lipase_like Monoglyceridelipase_lysophospholip Cutinase 6_AlphaBeta_hydrolase Piperidine Lipase inhibitor Sulfur Compound Thiadiazol
Lalistat-2 Acidic_Lipase Hormone-sensitive_lipase_like Monoglyceridelipase_lysophospholip Cutinase 6_AlphaBeta_hydrolase Piperidine Lipase inhibitor Sulfur Compound Thiadiazol
5LKR-6yc BCHE Piperidine Carboxamide Naphthalen
Donepezil-derivative-DZ7 ACHE Piperidine Derivative of Donepezil Inden
Donepezil-derivative-DZ0 ACHE Piperidine Derivative of Donepezil Inden
5DYT-5hb BCHE Piperidine Derivative of Donepezil Sulfonamide Sulfur Compound Naphthalen
5DYY-5hh BCHE Piperidine Derivative of Donepezil Sulfonamide Sulfur Compound Naphthalen
TAM1 Thioesterase Piperidine Benzofuran
Coumestan-cpd32 Thioesterase Piperidine Benzofuran
Coumestan-cpd8 Thioesterase Piperidine Benzofuran Chromen
TAM16 Thioesterase Piperidine Carboxamide Benzofuran
CHEMBL3687984 DPP4N_Peptidase_S9 Cyanide Piperidine Purine
CHEMBL3112966 DPP4N_Peptidase_S9 Piperidine
CHEMBL1951424 DPP4N_Peptidase_S9 Piperidine Cyanide Quinoline Pyrrolidine
Piperidinyl-1,2,3-triazole-urea-inhibitor-11 LYsophospholipase_carboxylesterase Piperidine Urea derivative Triazol
Piperidinyl-1,2,3-triazole-urea-inhibitor-12 LYsophospholipase_carboxylesterase Piperidine Urea derivative Triazol
Piperidinyl-1,2,3-triazole-urea-inhibitor-2 LYsophospholipase_carboxylesterase Carb_B_Chordata ABHD11-Acetyl_transferase PAF-Acetylhydrolase Cholesterol_esterase Piperidine Urea derivative Triazol
SCHEMBL13923509 DPP4N_Peptidase_S9 Pyrrolidine Piperidine
TPPU-methyl Epoxide_hydrolase Trifluoro Piperidine Urea derivative
SCHEMBL15272467 Epoxide_hydrolase Trifluoro Piperidine Urea derivative
TPPU Epoxide_hydrolase Trifluoro Piperidine Urea derivative
CHEMBL469792 Epoxide_hydrolase Piperidine Sulfur Compound Carboxamide Sulfonyl
CHEMBL2392714 Epoxide_hydrolase Trifluoro Piperidine Carboxamide Triazine
CHEMBL1615216 Epoxide_hydrolase Piperidine Urea derivative Cyclopropyl Carboxamide Oxadiazol
TAK-802 ACHE Piperidine
Z-Pro-Prolinal-derived S9N_PPCE_Peptidase_S9 Benzyloxycarbonyl Piperidine Peptide Pyrrolidine Carboxamide Carbamate
GSK237826A Prolylcarboxypeptidase Piperidine
N-piperidinopropylgalanthamine ACHE Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Piperidine Benzazepin Azepine
24D Epoxide_hydrolase Piperidine Pyrimidine Carboxamide
Piperidine-fused-benzimidazole-25 DPP4N_Peptidase_S9 Trifluoro Piperidine Sulfur Compound Imidazole Benzimidazole Sulfonyl
Piperidine-fused-benzimidazole-34 DPP4N_Peptidase_S9 Trifluoro Piperidine Benzimidazole
JJKK-048 Monoglyceridelipase_lysophospholip Benzodioxo Piperidine Triazol
Gemigliptin DPP4N_Peptidase_S9 Drug Piperidine Pyrimidine Gliptin Trifluoro
Gosogliptin DPP4N_Peptidase_S9 Drug Piperidine Pyrimidine Gliptin
Trelagliptin DPP4N_Peptidase_S9 Drug Piperidine Pyrimidine Cyanide Gliptin
CHEMBL4465514 Epoxide_hydrolase Piperidine Carboxamide Sulfur Compound
5ALH-4UA Epoxide_hydrolase Sulfonamide Carboxamide Sulfur Compound Piperidine Sulfonyl
5ALZ-XQ9 Epoxide_hydrolase Urea derivative Adamantyl Piperidine Sulfur Compound Sulfonyl Sulfonamide
5AM1-I5T Epoxide_hydrolase Piperidine Carboxamide Cyclopropyl Chromen
Triazolopiperazine-based-beta-amino-acid DPP4N_Peptidase_S9 Piperidine Trifluoro Triazol
GVB DPP4N_Peptidase_S9 Piperidine
Piperidinone-constrained-phenethylamine-31 DPP4N_Peptidase_S9 Benzodioxo Trifluoro Piperidine
Piperidine-constrained-phenethylamine-42 DPP4N_Peptidase_S9 Trifluoro Sulfur Compound Pyrimidine Piperidine
LIR DPP4N_Peptidase_S9 Cyanide Piperidine Imidazole
Xanthine-inhibitor-4 DPP4N_Peptidase_S9 Pyrimidine Piperidine Cyanide Purine
6Z8 DPP4N_Peptidase_S9 Purine Piperidine Gliptin Peptide
LASSBio-767 ACHE Natural Derivative of Spectaline Piperidine
LASSBio-822 ACHE Natural Derivative of Spectaline Piperidine tert-Butyl
CHEMBL4293015 BCHE Indole Piperidine Derivative of Donepezil Alkyl linked bis-ligand
CB2R-BCHE-x BCHE Multitarget Cannabinoid-Receptor-ligand Piperidine Imidazole Carboxamide
CB2R-BCHE-20a BCHE Multitarget Cannabinoid-Receptor-ligand Piperidine Imidazole Carboxamide
Contilisant ACHE BCHE Multitarget Histamine-Receptor3-H3-Antagonist Monoamine-oxidase-inhibitor Piperidine Indole
ASS234 ACHE Multitarget Monoamine-oxidase-inhibitor Alkyl linked bis-ligand Piperidine Indole
DL0410 ACHE BCHE Piperidine Biphenyl
5DYW-5hf-C11 BCHE Piperidine Derivative of Donepezil Sulfur Compound Sulfonamide PET probe Naphthalen
5DYW-5hf-F BCHE Piperidine Derivative of Donepezil Sulfur Compound Sulfonamide PET probe
5DYW-5hf BCHE Piperidine Derivative of Donepezil Sulfur Compound Sulfonamide Naphthalen
5NN0-cpd3 BCHE Piperidine Inden
6FSE-15 ACHE Piperidine
6FSD-10 ACHE Piperidine
STK133938 ACHE Piperidine Piperazine
Mebbpp ACHE Derivative of Donepezil Multitarget Sulfur Compound Piperidine
Selenepezil ACHE Organoselenium Thiol-reactive Derivative of Donepezil Piperidine
CHEMBL3114611 Epoxide_hydrolase Cyclopropyl Piperidine Urea derivative Carboxamide
AM6580 Monoglyceridelipase_lysophospholip Piperazine Piperidine Fluoren Triazol Urea derivative
SA-57 Monoglyceridelipase_lysophospholip Carbamate Piperidine
MGL-Inhibitor-26 Monoglyceridelipase_lysophospholip Piperidine Carboxamide Pyrazole
B401 Epoxide_hydrolase Urea derivative Adamantyl Piperidine
EC5026 Epoxide_hydrolase Urea derivative Trifluoro Piperidine
CHEMBL1938516 Prolylcarboxypeptidase Piperidine
CHEMBL1684295 Prolylcarboxypeptidase Pyrrolidine Imidazole Pyridine Oxadiazol Piperidine Benzimidazole
GTPL9797 PAF-Acetylhydrolase Trifluoro Piperidine Sulfur Compound Sulfonamide Benzenesulfonamide
Rilapladib PAF-Acetylhydrolase Trifluoro Piperidine Sulfur Compound
UAMC00039 Prolylcarboxypeptidase Piperidine
Alogliptin DPP4N_Peptidase_S9 Drug Piperidine Pyrimidine Cyanide Gliptin
Sitagliptin DPP4N_Peptidase_S9 Drug Piperidine Gliptin Triazol Trifluoro
CHEMBL238787 Hormone-sensitive_lipase_like Carb_B_Chordata ABHD6-Lip Trifluoro Carbamate Piperidine
BAY Hormone-sensitive_lipase_like Piperidine Urea derivative
JZL184 Monoglyceridelipase_lysophospholip Carb_B_Chordata ABHD6-Lip Piperidine Benzodioxo FAAH inhibitor Multitarget pNP
64D Monoglyceridelipase_lysophospholip Piperidine PET probe Sulfonyl Sulfur Compound
KML29 Monoglyceridelipase_lysophospholip Plasmodium_subtelomeric_PST-A Halo ketone Piperidine Benzodioxo Carbamate Trifluoro
KT195 ABHD6-Lip Piperidine Biphenyl Triazol
KT172 Lipase_3 Carb_B_Chordata ABHD6-Lip Piperidine Biphenyl Triazol
KT109 Lipase_3 Carb_B_Chordata ABHD6-Lip Piperidine Biphenyl Triazol
WWL229 Carb_B_Chordata pNP Carbamate Piperidine
C7653 ACHE Piperidine Derivative of Donepezil
4-piperidino-piperidine Carb_B_Chordata Leaving group Derivative of Irinotecan Piperidine
40V BCHE Piperidine Quinoline Multitarget Carboxamide Metal ion chelator Inden
3F9 BCHE Piperidine Inden Carboxamide Naphthalen
T-82(1) ACHE Piperidine Quinoline
Aricept~Donepezil~E2020 ACHE Derivative of Donepezil Piperidine Drug Inden
Biscarbamate-Cpd16 Derivative of Bambuterol Carbamate Piperidine
KW-5092 ACHE Piperidine Imidazole
Meperidine BCHE Carboxylesterase Carb_B_Chordata Piperidine Drug Not A\/B H target Opioid analgesic
Pitofenone ACHE Piperidine Benzoate
TAK-147 ACHE Piperidine Derivative of Donepezil Transition state analogue Benzazepin
Icopezil ACHE Piperidine Derivative of Donepezil
Vecuronium BCHE Neuromuscular Nondepolarizing Agents Nicotinic antagonist Aminosteroid Piperidine Drug Acetate Not A\/B H target