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Piperidine

General

Heterocyclic amine consisting of a six-membered ring containing five methylene bridges (CH2) and one amine bridge (NH). Building block for many inhibitors of enzymes
Inhibitor Main targeted enzyme families Type Structure
CHEMBL1622595 ACHE Piperidine
CHEMBL4756662 Monoglyceridelipase_lysophospholip Piperidine Oxazine
RIV-Piperidine-Cpd6a BCHE Piperidine Derivative of Rivastigmine Carbamate
CHEMBL5176915 Monoglyceridelipase_lysophospholip Pyridine Piperidine Trifluoro
MAGL-IN-10-Cpd28 Monoglyceridelipase_lysophospholip Pyridine Piperidine Trifluoro Sulfur Compound
Galantamine-benzylpyridine-C2 ACHE BCHE Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Piperidine Pyridine Benzazepin Azepane
SCHEMBL23211786 Monoglyceridelipase_lysophospholip Piperidine Oxazine
CHEMBL5195416 ACHE Monoamine-oxidase-inhibitor Multitarget Piperidine Antioxidant
Flucopride ACHE Multitarget 5-HT-receptor-ligand Piperidine
SCHEMBL22488617 Monoglyceridelipase_lysophospholip Piperidine Trifluoro Oxazine
SCHEMBL21061872 Monoglyceridelipase_lysophospholip Benzoxazine Piperidine
SCHEMBL22491361 Monoglyceridelipase_lysophospholip Benzoxazine Piperidine Indole
SCHEMBL22462763 Monoglyceridelipase_lysophospholip Piperidine Trifluoro Oxazine
MAGL11 Monoglyceridelipase_lysophospholip Piperidine Formamide
SW-17 Epoxide_hydrolase Sulfur Compound Multitarget Thiazole Piperidine Carboxamide
Sulphostin DPP4N_Peptidase_S9 Natural Sulfur Compound Piperidine
Benzylpiperidin-methylene-methoxy-dihydro-inden-one ACHE Inden BACE1-inhibitor Derivative of Donepezil Multitarget Piperidine
Periciazine BCHE Not AlphaBeta Hydrolase target Phenothiazine Multitarget Drug Sulfur Compound Piperidine Cyanide
sEH-HDAC6-Cpd28g Epoxide_hydrolase Urea derivative Multitarget HDAC inhibitor Piperidine Carboxamide
GL-B437 Epoxide_hydrolase Urea derivative Adamantyl Piperidine Carboxamide
Contilistat Multitarget Histamine-Receptor3-H3-Antagonist Monoamine-oxidase-inhibitor Piperidine Indole HDAC inhibitor prop-2-yn-1-yl Sulfur Compound
MR33317 ACHE Multitarget 5-HT-receptor-ligand Piperidine
Ezurpimtrostat Palmitoyl-protein_thioesterase Piperidine Quinoline
Lyplal1-IN-1 LYsophospholipase_carboxylesterase Piperidine Urea derivative Triazol Morpholine Pyrimidine
75J-34n DPP4N_Peptidase_S9 Piperidine Imidazole Purine Cyanide
X20419 Thioesterase Piperazine Piperidine Pyrimidine Carboxamide Indole
ADS031 ACHE Histamine-Receptor3-H3-Antagonist Multitarget Piperidine Naphthalen
CHEMBL459756 ACHE BCHE Histamine-Receptor3-H3-Antagonist Multitarget Piperidine
FUB833 ACHE BCHE Acridine Derivative of Tacrine Alkyl linked bis-ligand Histamine-Receptor3-H3-Antagonist Multitarget Piperidine
Piperidine-4-carboxamide-alkyl-tacrine-cpd16 ACHE BCHE Acridine Derivative of Tacrine Alkyl linked bis-ligand Piperidine Carboxamide
Coumarin-dimethoxyphenyl-methylpiperidine-carboxamise-cpd3b ACHE Coumarin Piperidine Carboxamide Derivative of Donepezil Chromen
Benzylpiperidin-methylsulfonyl-indol-acryloyl-phenyl-acetamide-cpd6b BCHE ACHE Multitarget Indole Carboxamide Piperidine Derivative of Donepezil Sulfur Compound
Benzylpiperidin-oxoindolin-acetamide-Cpd23 ACHE Derivative of Donepezil Piperidine Indole
Indole-piperidine-amide-cpd23a ACHE Multitarget Indole Carboxamide Derivative of Donepezil BACE1-inhibitor Piperidine
SB-1448 BCHE ACHE Multitarget Derivative of Donepezil BACE1-inhibitor Piperidine
Triazole-carbonylpiperidin-diphenylazetidin-2-one-5d Monoglyceridelipase_lysophospholip Piperidine Triazol Azetidin
Triazole-carbonylpiperidin-diphenylazetidin-2-one-5d-F28 Piperidine Triazol Azetidin
Benzo-triazole-carbonylpiperidin-benzodioxol-fluorophenylazetidin-2-one-5v Monoglyceridelipase_lysophospholip Benzodioxo Piperidine Triazol Azetidin
M-18C Monoglyceridelipase_lysophospholip Carboxamide Piperidine Indole
SCHEMBL3454366 Epoxide_hydrolase Urea derivative Piperidine
SCHEMBL3454366-Boc Epoxide_hydrolase Urea derivative tert-Butyl Piperidine
SCHEMBL3454366-Isobutyryl Epoxide_hydrolase Piperidine Urea derivative
Benzofuran-carbonyl-benzyloxy-piperidine-Cpd8 ACHE Benzofuran Piperidine Acaricide
J8-A34 ACHE Piperidine Sulfur Compound Sulfonamide Quinoline Derivative of Donepezil
Compound5d-Benzylpiperidine-Phenyl-oxadiazol-thiol ACHE anti-Abeta-aggregation Sulfur Compound BACE1-inhibitor Piperidine Multitarget Carboxamide Oxadiazol Derivative of Donepezil Cyanide
C4I-7QHE BCHE Acridine Alkyl linked bis-ligand Derivative of Tacrine Carboxamide Derivative of Donepezil Naphthalen Piperidine
C0I-7QHD BCHE Acridine Alkyl linked bis-ligand Derivative of Tacrine Carboxamide Derivative of Donepezil Indole Piperidine
JZP-MA-11 ABHD6-Lip Sulfur Compound PET probe Thiadiazol Piperidine Carbamate
4c2-AChE-IN-24 ACHE Sulfur Compound Multitarget Piperidine
AZ12756122 Thioesterase Sulfonamide Piperidine Cyanide Sulfur Compound
AA692 Piperidine Triazol tert-Butyl
Loperamide Carb_B_Chordata Piperidine Drug Not AlphaBeta Hydrolase target Opioid analgesic
DFAH-12 BCHE ACHE Piperidine Hydroxycinnamic-ester Multitarget Antioxidant Derivative of Donepezil
ZLWH-23 ACHE Piperidine GSK-3 kinase inhibitor Carboxamide Multitarget Indole Cyclopropyl beta-carboline
Chlorophenyl-sulfonyl-quinolin-piperidine-carboxamide-4d Epoxide_hydrolase Piperidine Sulfur Compound Sulfonamide Carboxamide Multitarget
m-Amino-donepezil ACHE Derivative of Donepezil Piperidine Inden
NSD1819 Monoglyceridelipase_lysophospholip Benzodioxo Piperidine Triazol Azetidin
MAGL23 Monoglyceridelipase_lysophospholip Piperidine
MAGL17b Monoglyceridelipase_lysophospholip Piperidine
Lalistat-alkyne-probe Acidic_Lipase 6_AlphaBeta_hydrolase Cutinase Hormone-sensitive_lipase_like Monoglyceridelipase_lysophospholip Piperidine Lipase inhibitor Sulfur Compound Thiadiazol Alkyne ABPP-Probe
ML226 ABHD11-Acetyl_transferase Lipase_3 Triazol Piperidine
Fotagliptin DPP4N_Peptidase_S9 Gliptin Cyanide Piperidine Triazine
CHEMBL57478 Pectinacetylesterase-Notum Fragment inhibitor of Notum Piperidine Indole
3-butyl-6-benzyloxyphthalide-Mannich-base-7d ACHE Monoamine-oxidase-inhibitor Multitarget Piperidine Benzofuran
TPPU-6-Chlorotacrine-12c Epoxide_hydrolase ACHE Multitarget Derivative of Tacrine Trifluoro Piperidine Urea derivative Alkyl linked bis-ligand
Fragment-886 Pectinacetylesterase-Notum Fragment inhibitor of Notum Piperidine Pyrazole
Fragment-201 Pectinacetylesterase-Notum Fragment inhibitor of Notum Piperidine Oxadiazol
Fragment-634 Pectinacetylesterase-Notum Fragment inhibitor of Notum Cyanide Piperidine
Piperine Pectinacetylesterase-Notum Fragment inhibitor of Notum Piperidine Natural Benzodioxo
Benzothiazole-analogue-13f Epoxide_hydrolase Benzothiazol Piperidine Sulfur Compound Sulfonamide Carboxamide
FAAH_sEH_4.5 Epoxide_hydrolase Multitarget FAAH inhibitor Benzothiazol Piperidine Sulfur Compound Carboxamide
CHEMBL2313198 Epoxide_hydrolase Piperidine Sulfur Compound Sulfonamide Carboxamide Trifluoro
CHEMBL3233607-S0G-3WKA Epoxide_hydrolase Piperidine Pyrimidine
H0L-7D9O ACHE Inden Piperidine Derivative of Donepezil
H1R-7D9Q ACHE Inden Piperidine Derivative of Donepezil
H0R-7D9P ACHE Inden Piperidine Derivative of Donepezil
WAY-121898 Cholesterol_esterase Carbamate Piperidine Phenoxyphenyl
XP7-7L4U Monoglyceridelipase_lysophospholip Piperidine Pyrrolidine
MAGL-2305 Monoglyceridelipase_lysophospholip PET probe Piperidine Azaspiro
SCHEMBL19421059 Monoglyceridelipase_lysophospholip Azaspiro Piperidine
SCHEMBL19834081 Monoglyceridelipase_lysophospholip Benzoxazine Piperidine
ABC47 abh_upf0017 CGI-58_ABHD5_ABHD4 Carbamate Piperidine N-hydroxyhydantoin Phenoxyphenyl
ABC51 CGI-58_ABHD5_ABHD4 Carbamate Piperidine N-hydroxyhydantoin Phenoxyphenyl
JJH251 Carbamate Piperidine N-hydroxyhydantoin
WHP313 S9N_PREPL_Peptidase_S9 Piperidine
JJH221 Carbamate Piperidine N-hydroxyhydantoin tert-Butyloxycarbonyl tert-Butyl
ABC44 Palmitoyl-protein_thioesterase Carbamate Piperidine N-hydroxyhydantoin
DH376 Lipase_3 Piperidine Triazol Urea derivative
ML211 LYsophospholipase_carboxylesterase ABHD11-Acetyl_transferase Piperidine Triazol tert-Butyl
KT185 ABHD6-Lip Piperidine Triazol
KT203 ABHD6-Lip Piperidine Triazol
KT182 ABHD6-Lip Piperidine Triazol
Pyranone-carbamate-cpd7p BCHE Carbamate Piperidine Antioxidant
6SAM-cpd13 BCHE Multitarget Piperidine Inden Monoamine-oxidase-inhibitor Carbamate
6RUA-3a BCHE Sulfur Compound Sulfonamide Coumarin Piperidine Carboxamide Naphthalen Chromen
JU5 BCHE Coumarin Piperidine Carboxamide Naphthalen Sulfur Compound Chromen
JUB BCHE Piperidine Piperazine NBD-nitro-benzoxadiazol-fluorescent Benzoxadiazole Sulfur Compound Sulfonamide Naphthalen
75M-5T4F DPP4N_Peptidase_S9 Piperidine Quinazoline Cyanide Purine
75L-5T4E DPP4N_Peptidase_S9 Piperidine Pyrimidine Quinazoline Purine
75N-5T4B DPP4N_Peptidase_S9 Piperidine Quinazoline Purine
TUPS Epoxide_hydrolase Piperidine Urea derivative Trifluoro Sulfur Compound Sulfonamide
UW-MD-71 ACHE BCHE Cholinesterase Piperidine Quinazoline Multitarget Histamine-Receptor3-H3-Antagonist
FG1912 ACHE GSK-3 kinase inhibitor Multitarget Pyridine Piperidine Cyclopropyl Carboxamide Derivative of Donepezil
GD29 ACHE GSK-3 kinase inhibitor Multitarget Thiazole Pyridine Piperidine Cyclopropyl Carboxamide Sulfur Compound Derivative of Donepezil
Donecopride ACHE Multitarget 5-HT-receptor-ligand Derivative of Donepezil Piperidine
RS67333 ACHE Multitarget 5-HT-receptor-ligand Piperidine
Phenolic-deriv-Donecopride-4 ACHE Multitarget 5-HT-receptor-ligand Derivative of Donepezil Piperidine
Phenolic-deriv-Donecopride-20 ACHE Carbamate Multitarget 5-HT-receptor-ligand Derivative of Donepezil Piperidine
Sigma1R-ACHE-6a ACHE Multitarget 5-HT-receptor-ligand Piperidine Sigma1R Indole Derivative of Donepezil
Sigma1R-ACHE-6b ACHE Multitarget 5-HT-receptor-ligand Piperidine Sigma1R Indole Derivative of Donepezil
AS2586144 Epoxide_hydrolase Piperidine Benzoate Cyclopropyl
6F7Q-cpd11 BCHE Multitarget Antioxidant Piperidine Quinoline Metal ion chelator Inden Carboxamide
Lalistat-1 Acidic_Lipase Hormone-sensitive_lipase_like Monoglyceridelipase_lysophospholip Cutinase 6_AlphaBeta_hydrolase Piperidine Lipase inhibitor Sulfur Compound Thiadiazol
Lalistat-2 Acidic_Lipase Hormone-sensitive_lipase_like Monoglyceridelipase_lysophospholip Cutinase 6_AlphaBeta_hydrolase Piperidine Lipase inhibitor Sulfur Compound Thiadiazol
5LKR-6yc BCHE Piperidine Carboxamide Naphthalen
Donepezil-derivative-DZ7 ACHE Piperidine Derivative of Donepezil Inden
Donepezil-derivative-DZ0 ACHE Piperidine Derivative of Donepezil Inden
5DYT-5hb BCHE Piperidine Derivative of Donepezil Sulfonamide Sulfur Compound Naphthalen
5DYY-5hh BCHE Piperidine Derivative of Donepezil Sulfonamide Sulfur Compound Naphthalen
TAM1 Thioesterase Piperidine Benzofuran
Coumestan-cpd32 Thioesterase Piperidine Benzofuran
Coumestan-cpd8 Thioesterase Piperidine Benzofuran Chromen
TAM16 Thioesterase Piperidine Carboxamide Benzofuran
CHEMBL3687984 DPP4N_Peptidase_S9 Cyanide Piperidine Purine
CHEMBL3112966 DPP4N_Peptidase_S9 Piperidine
CHEMBL1951424 DPP4N_Peptidase_S9 Piperidine Cyanide Quinoline Pyrrolidine
Piperidinyl-1,2,3-triazole-urea-inhibitor-11 LYsophospholipase_carboxylesterase Piperidine Urea derivative Triazol
Piperidinyl-1,2,3-triazole-urea-inhibitor-12 LYsophospholipase_carboxylesterase Piperidine Urea derivative Triazol
Piperidinyl-1,2,3-triazole-urea-inhibitor-2 LYsophospholipase_carboxylesterase Carb_B_Chordata ABHD11-Acetyl_transferase PAF-Acetylhydrolase Cholesterol_esterase Piperidine Urea derivative Triazol
SCHEMBL13923509 DPP4N_Peptidase_S9 Pyrrolidine Piperidine
TPPU-methyl Epoxide_hydrolase Trifluoro Piperidine Urea derivative
SCHEMBL15272467 Epoxide_hydrolase Trifluoro Piperidine Urea derivative
TPPU Epoxide_hydrolase Trifluoro Piperidine Urea derivative
CHEMBL469792 Epoxide_hydrolase Piperidine Sulfur Compound Carboxamide Sulfonyl
CHEMBL2392714 Epoxide_hydrolase Trifluoro Piperidine Carboxamide Triazine
CHEMBL1615216 Epoxide_hydrolase Piperidine Urea derivative Cyclopropyl Carboxamide Oxadiazol
TAK-802 ACHE Piperidine
Z-Pro-Prolinal-derived S9N_PPCE_Peptidase_S9 Benzyloxycarbonyl Piperidine Peptide Pyrrolidine Carboxamide Carbamate
GSK237826A Prolylcarboxypeptidase Piperidine
N-piperidinopropylgalanthamine ACHE Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Piperidine Benzazepin Azepane
24D Epoxide_hydrolase Piperidine Pyrimidine Carboxamide
Piperidine-fused-benzimidazole-25 DPP4N_Peptidase_S9 Trifluoro Piperidine Sulfur Compound Imidazole Benzimidazole Sulfonyl
Piperidine-fused-benzimidazole-34 DPP4N_Peptidase_S9 Trifluoro Piperidine Benzimidazole
JJKK-048 Monoglyceridelipase_lysophospholip Benzodioxo Piperidine Triazol
Gemigliptin DPP4N_Peptidase_S9 Drug Piperidine Pyrimidine Gliptin Trifluoro
Gosogliptin DPP4N_Peptidase_S9 Drug Piperidine Pyrimidine Gliptin
Trelagliptin DPP4N_Peptidase_S9 Drug Piperidine Pyrimidine Cyanide Gliptin
CHEMBL4465514 Epoxide_hydrolase Piperidine Carboxamide Sulfur Compound Thiophen
5ALH-4UA Epoxide_hydrolase Sulfonamide Carboxamide Sulfur Compound Piperidine Sulfonyl
5ALZ-XQ9 Epoxide_hydrolase Urea derivative Adamantyl Piperidine Sulfur Compound Sulfonyl Sulfonamide
5AM1-I5T Epoxide_hydrolase Piperidine Carboxamide Cyclopropyl Chromen
Triazolopiperazine-based-beta-amino-acid DPP4N_Peptidase_S9 Piperidine Trifluoro Triazol
GVB DPP4N_Peptidase_S9 Piperidine
Piperidinone-constrained-phenethylamine-31 DPP4N_Peptidase_S9 Benzodioxo Trifluoro Piperidine
Piperidine-constrained-phenethylamine-42 DPP4N_Peptidase_S9 Trifluoro Sulfur Compound Pyrimidine Piperidine
LIR DPP4N_Peptidase_S9 Cyanide Piperidine Imidazole
Xanthine-inhibitor-4 DPP4N_Peptidase_S9 Pyrimidine Piperidine Cyanide Purine
6Z8 DPP4N_Peptidase_S9 Purine Piperidine Gliptin Peptide
LASSBio-767 ACHE Natural Derivative of Spectaline Piperidine
LASSBio-822 ACHE Natural Derivative of Spectaline Piperidine tert-Butyl
CHEMBL4293015 BCHE Indole Piperidine Derivative of Donepezil Alkyl linked bis-ligand
CB2R-BCHE-x BCHE Multitarget Cannabinoid-Receptor-ligand Piperidine Imidazole Carboxamide
CB2R-BCHE-20a BCHE Multitarget Cannabinoid-Receptor-ligand Piperidine Imidazole Carboxamide
Contilisant ACHE BCHE Multitarget Histamine-Receptor3-H3-Antagonist Monoamine-oxidase-inhibitor Piperidine Indole prop-2-yn-1-yl
ASS234 ACHE Multitarget Monoamine-oxidase-inhibitor Alkyl linked bis-ligand Piperidine Indole
DL0410 ACHE BCHE Piperidine Biphenyl
5DYW-5hf-C11 BCHE Piperidine Derivative of Donepezil Sulfur Compound Sulfonamide PET probe Naphthalen
5DYW-5hf-F BCHE Piperidine Derivative of Donepezil Sulfur Compound Sulfonamide PET probe
5DYW-5hf BCHE Piperidine Derivative of Donepezil Sulfur Compound Sulfonamide Naphthalen
5NN0-cpd3 BCHE Piperidine Inden
6FSE-15 ACHE Piperidine Piperazine
6FSD-10 ACHE Piperidine
STK133938 ACHE Piperidine Piperazine
Mebbpp ACHE Derivative of Donepezil Multitarget Sulfur Compound Piperidine
Selenepezil ACHE Organoselenium Thiol-reactive Derivative of Donepezil Piperidine
CHEMBL3114611 Epoxide_hydrolase Cyclopropyl Piperidine Urea derivative Carboxamide
AM6580 Monoglyceridelipase_lysophospholip Piperazine Piperidine Fluoren Triazol Urea derivative
SA-57 Monoglyceridelipase_lysophospholip Carbamate Piperidine
MGL-Inhibitor-26 Monoglyceridelipase_lysophospholip Piperidine Carboxamide Pyrazole
B401 Epoxide_hydrolase Urea derivative Adamantyl Piperidine
EC5026 Epoxide_hydrolase Urea derivative Trifluoro Piperidine Drug
CHEMBL1938516 Prolylcarboxypeptidase Piperidine
CHEMBL1684295 Prolylcarboxypeptidase Pyrrolidine Imidazole Pyridine Oxadiazol Piperidine Benzimidazole
GTPL9797 PAF-Acetylhydrolase Trifluoro Piperidine Sulfur Compound Sulfonamide Benzenesulfonamide
Rilapladib PAF-Acetylhydrolase Trifluoro Piperidine Sulfur Compound
UAMC00039 Prolylcarboxypeptidase Piperidine
Alogliptin DPP4N_Peptidase_S9 Drug Piperidine Pyrimidine Cyanide Gliptin
Sitagliptin DPP4N_Peptidase_S9 Drug Piperidine Gliptin Triazol Trifluoro
CHEMBL238787 Hormone-sensitive_lipase_like Carb_B_Chordata ABHD6-Lip Trifluoro Carbamate Piperidine
BAY-59-9435 Hormone-sensitive_lipase_like Piperidine Urea derivative
JZL184 Monoglyceridelipase_lysophospholip Carb_B_Chordata ABHD6-Lip Piperidine Benzodioxo FAAH inhibitor Multitarget pNP
64D Monoglyceridelipase_lysophospholip Piperidine PET probe Sulfonyl Sulfur Compound
KML29 Monoglyceridelipase_lysophospholip Plasmodium_subtelomeric_PST-A Halo ketone Piperidine Benzodioxo Carbamate Trifluoro
KT195 ABHD6-Lip Piperidine Biphenyl Triazol
KT172 Lipase_3 Carb_B_Chordata ABHD6-Lip Piperidine Biphenyl Triazol
Cpd-2-ABHD2 abh_upf0017 Piperidine
KT109 Lipase_3 Carb_B_Chordata ABHD6-Lip abh_upf0017 Piperidine Biphenyl Triazol
WWL229 Carb_B_Chordata pNP Carbamate Piperidine
C7653 ACHE Piperidine Derivative of Donepezil
4-piperidino-piperidine Carb_B_Chordata Leaving group Derivative of Irinotecan Piperidine
40V BCHE Piperidine Quinoline Multitarget Carboxamide Metal ion chelator Inden
3F9 BCHE Piperidine Inden Carboxamide Naphthalen
E2030 ACHE BCHE Piperidine Benzoxazine Oxazine
T-82(1) ACHE Piperidine Quinoline
Aricept~Donepezil~E2020 ACHE Derivative of Donepezil Piperidine Drug Inden
Biscarbamate-Cpd16 BCHE Derivative of Bambuterol Carbamate Piperidine
KW-5092 ACHE Piperidine Imidazole
Meperidine BCHE Carboxylesterase Carb_B_Chordata Piperidine Drug Not AlphaBeta Hydrolase target Opioid analgesic
Fluoro-piperidin-ethyl-carbazole-15g BCHE Piperidine Carbazol beta-carboline
Ethylpiperidinyl-ethyl-indole-Cpd19 BCHE Indole Piperidine Natural
N-benzylpiperidine-carbazol-9c BCHE Piperidine Carbazol beta-carboline Derivative of Donepezil Multitarget
Pitofenone ACHE Piperidine Benzoate
TAK-147 ACHE Piperidine Derivative of Donepezil Transition state analogue Benzazepin
Icopezil ACHE Piperidine Derivative of Donepezil Benzoxazol
Vecuronium BCHE Neuromuscular Nondepolarizing Agents Nicotinic antagonist Aminosteroid Piperidine Drug Acetate Not AlphaBeta Hydrolase target