Tat-(1-9)
DPPIV peptidase activity is inhibited by N-terminal nonapeptide Tat-(1-9) of Tat protein from human immunodeficiency virus (HIV)-1 with amino acid sequence MDPVDPNIE
General
Type : Peptide, Pyrrolidine, Sulfur Compound
Chemical_Nomenclature : (2S)-2-[[(2S,3S)-2-[[(2S)-4-amino-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-carboxypropanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-3-carboxypropanoyl]pyrrolidine-2-carbonyl]amino]-4-oxobutanoyl]amino]-3-methylpentanoyl]amino]pentanedioic acid
Canonical SMILES : CCC(C)C(C(=O)NC(CCC(=O)O)C(=O)O)NC(=O)C(CC(=O)N)NC(=O)C1CCCN1C(=O)C(CC(=O)O)NC(=O)C(C(C)C)NC(=O)C2CCCN2C(=O)C(CC(=O)O)NC(=O)C(CCSC)N
InChI : InChI=1S\/C43H68N10O17S\/c1-6-21(4)34(40(66)46-23(43(69)70)11-12-30(55)56)51-36(62)24(17-29(45)54)47-37(63)27-9-7-14-52(27)42(68)26(19-32(59)60)49-39(65)33(20(2)3)50-38(64)28-10-8-15-53(28)41(67)25(18-31(57)58)48-35(61)22(44)13-16-71-5\/h20-28,33-34H,6-19,44H2,1-5H3,(H2,45,54)(H,46,66)(H,47,63)(H,48,61)(H,49,65)(H,50,64)(H,51,62)(H,55,56)(H,57,58)(H,59,60)(H,69,70)\/t21-,22-,23-,24-,25-,26-,27-,28-,33-,34-\/m0\/s1
InChIKey : FBRBBGLUJRXRGJ-MQMIXWJCSA-N
Other name(s) : HIV-1 Tat(1-9) || HIV-1 tat Protein (1-9) || 200203-20-9 || H-Met-Asp-Pro-Val-Asp-Pro-Asn-Ile-Glu-OH || MDPVDPNIE
MW : 1029.13
Formula : C43H68N10O17S
CAS_number :
PubChem : 100915314
UniChem : FBRBBGLUJRXRGJ-MQMIXWJCSA-N
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Target
Families : Tat-(1-9) ligand of proteins in family
DPP4N_Peptidase_S9
Structure :
2BGR
Protein :
human-DPP4
References (2)
| Title : Comparative molecular dynamics reveal ligand-dependent structural and dynamic determinants of dipeptidyl peptidase IV recognition and inhibition - Eltayb_2026_J.Biomol.Struct.Dyn__1 |
| Author(s) : Eltayb WA , Abdalla M , Abdalla SF , Saikia T , Hamadi A , Barnawi J , El-Arabey AA , Zothantluanga JH |
| Ref : J Biomol Struct Dyn , :1 , 2026 |
| Abstract : |
| PubMedSearch : Eltayb_2026_J.Biomol.Struct.Dyn__1 |
| PubMedID: 42170713 |
| Gene_locus related to this paper: human-DPP4 |
| Title : Crystal structures of HIV-1 Tat-derived nonapeptides Tat-(1-9) and Trp2-Tat-(1-9) bound to the active site of dipeptidyl-peptidase IV (CD26) - Weihofen_2005_J.Biol.Chem_280_14911 |
| Author(s) : Weihofen WA , Liu J , Reutter W , Saenger W , Fan H |
| Ref : Journal of Biological Chemistry , 280 :14911 , 2005 |
| Abstract : |
| PubMedSearch : Weihofen_2005_J.Biol.Chem_280_14911 |
| PubMedID: 15695814 |
| Gene_locus related to this paper: human-DPP4 |