Tetrahydrofurobenzofuran
Related to Eseroline and Physovenol. Building block of carbamates inhibitors of AChE
General
Type : Leaving group, Benzofuran
Chemical_Nomenclature : 8b-methyl-2,3a-dihydro-1H-furo[2,3-b][1]benzofuran-7-ol || (8bS)-8b-methyl-2,3a-dihydro-1H-furo[2,3-b][1]benzofuran-7-ol
Canonical SMILES : CC12CCOC1OC3=C2C=C(C=C3)O || C[C@@]12CCOC1OC3=C2C=C(C=C3)O
InChI : InChI=1S\/C11H12O3\/c1-11-4-5-13-10(11)14-9-3-2-7(12)6-8(9)11\/h2-3,6,10,12H,4-5H2,1H3 || InChI=1S\/C11H12O3\/c1-11-4-5-13-10(11)14-9-3-2-7(12)6-8(9)11\/h2-3,6,10,12H,4-5H2,1H3\/t10?,11-\/m0\/
InChIKey : AMEMXGMNMDBQGD-UHFFFAOYSA-N || AMEMXGMNMDBQGD-DTIOYNMSSA-N
Other name(s) :
MW : 192.21
Formula : C11H12O3
CAS_number :
UniChem : AMEMXGMNMDBQGD-UHFFFAOYSA-N, AMEMXGMNMDBQGD-DTIOYNMSSA-N
Target
References (3)
| Title : Accommodation of physostigmine and its analogues by acetylcholinesterase is dominated by hydrophobic interactions - Barak_2009_Biochem.J_417_213 |
| Author(s) : Barak D , Ordentlich A , Stein D , Yu QS , Greig NH , Shafferman A |
| Ref : Biochemical Journal , 417 :213 , 2009 |
| Abstract : |
| PubMedSearch : Barak_2009_Biochem.J_417_213 |
| PubMedID: 18729824 |
| Title : Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine - Luo_2005_J.Med.Chem_48_986 |
| Author(s) : Luo W , Yu QS , Zhan M , Parrish D , Deschamps JR , Kulkarni SS , Holloway HW , Alley GM , Lahiri DK , Brossi A , Greig NH |
| Ref : Journal of Medicinal Chemistry , 48 :986 , 2005 |
| Abstract : |
| PubMedSearch : Luo_2005_J.Med.Chem_48_986 |
| PubMedID: 15715468 |
| Title : Syntheses of tetrahydrofurobenzofurans and dihydromethanobenzodioxepines from 5-hydroxy-3-methyl-3H-benzofuran-2-one. Rearrangement and ring expansion under reductive conditions on treatment with hydrides - Luo_2005_J.Org.Chem_70_6171 |
| Author(s) : Luo W , Yu QS , Holloway HW , Parrish D , Greig NH , Brossi A |
| Ref : J Org Chem , 70 :6171 , 2005 |
| Abstract : |
| PubMedSearch : Luo_2005_J.Org.Chem_70_6171 |
| PubMedID: 16050674 |