Triflupromazine

Dopaminergic antagonist, an antiemetic, a first generation antipsychotic and an anticoronaviral agent

General

Type : Phenothiazine, Sulfur Compound, Trifluoro, Not A\/B H target

Chemical_Nomenclature : N,N-dimethyl-3-[2-(trifluoromethyl)phenothiazin-10-yl]propan-1-amine

Canonical SMILES : CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)C(F)(F)F

InChI : InChI=1S\/C18H19F3N2S\/c1-22(2)10-5-11-23-14-6-3-4-7-16(14)24-17-9-8-13(12-15(17)23)18(19,20)21\/h3-4,6-9,12H,5,10-11H2,1-2H3

InChIKey : XSCGXQMFQXDFCW-UHFFFAOYSA-N

Other name(s) : triflupromazine  ||  Fluopromazine  ||  Trifluopromazine  ||  Vesprin  ||  Adazine  ||  CHEBI:9711  ||  CHEMBL570  ||  SCHEMBL44085  ||  ZINC538507


MW : 352.4

Formula : C18H19F3N2S

CAS_number : 146-54-3

PubChem : 5568

UniChem : XSCGXQMFQXDFCW-UHFFFAOYSA-N

Target

References (4)

Title : Inactivation of cholinesterase induced by chlorpromazine cation radicals - Muraoka_2003_Pharmacol.Toxicol_92_100
Author(s) : Muraoka S , Miura T
Ref : Pharmacol Toxicol , 92 :100 , 2003
Abstract :
PubMedSearch : Muraoka_2003_Pharmacol.Toxicol_92_100
PubMedID: 12747580

Title : Inhibition of butyrylcholinesterase by phenothiazine derivatives - Debord_2002_J.Enzyme.Inhib.Med.Chem_17_197
Author(s) : Debord J , Merle L , Bollinger JC , Dantoine T
Ref : J Enzyme Inhib Med Chem , 17 :197 , 2002
Abstract :
PubMedSearch : Debord_2002_J.Enzyme.Inhib.Med.Chem_17_197
PubMedID: 12443046

Title : Influence of dietary protein on the effect of coumaphos and triflupromazine interaction in sheep - Gopal_1976_Am.J.Vet.Res_37_1143
Author(s) : Gopal T , Oehme FW , Omer S
Ref : American Journal of Veterinary Research , 37 :1143 , 1976
Abstract :
PubMedSearch : Gopal_1976_Am.J.Vet.Res_37_1143
PubMedID: 984539

Title : Central and peripheral actions of anticholinergic drugs when administered with triflupromazine -
Author(s) : Brimblecombe RW , Green DM , Aldous FA , Thompson PB
Ref : Neuropharmacology , 10 :93 , 1971
PubMedID: 5569310