Triflupromazine
Dopaminergic antagonist, an antiemetic, a first generation antipsychotic and an anticoronaviral agent. Triflupromazine binds to the dopamine D1 and dopamine D2 receptors and inhibits their activity. Also binds the muscarinic acetylcholine receptors (M1 and M2) and the tryptamine D receptors (5HT2B). IC50 eqBChE 7.4 microM (Tasso et al.) Ki 3.01 microM (Debord et al.)
General
Type : Phenothiazine, Sulfur Compound, Trifluoro, Not A\/B H target
Chemical_Nomenclature : N,N-dimethyl-3-[2-(trifluoromethyl)phenothiazin-10-yl]propan-1-amine
Canonical SMILES : CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)C(F)(F)F
InChI : InChI=1S\/C18H19F3N2S\/c1-22(2)10-5-11-23-14-6-3-4-7-16(14)24-17-9-8-13(12-15(17)23)18(19,20)21\/h3-4,6-9,12H,5,10-11H2,1-2H3
InChIKey : XSCGXQMFQXDFCW-UHFFFAOYSA-N
Other name(s) : triflupromazine || Fluopromazine || Trifluopromazine || Vesprin || Adazine || CHEBI:9711 || CHEMBL570 || SCHEMBL44085 || ZINC538507
MW : 352.4
Formula : C18H19F3N2S
CAS_number : 146-54-3
PubChem : 5568
UniChem : XSCGXQMFQXDFCW-UHFFFAOYSA-N
Target
References (5)
| Title : Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease - Tasso_2011_Eur.J.Med.Chem_46_2170 |
| Author(s) : Tasso B , Catto M , Nicolotti O , Novelli F , Tonelli M , Giangreco I , Pisani L , Sparatore A , Boido V , Carotti A , Sparatore F |
| Ref : Eur Journal of Medicinal Chemistry , 46 :2170 , 2011 |
| Abstract : |
| PubMedSearch : Tasso_2011_Eur.J.Med.Chem_46_2170 |
| PubMedID: 21459491 |
| Title : Inactivation of cholinesterase induced by chlorpromazine cation radicals - Muraoka_2003_Pharmacol.Toxicol_92_100 |
| Author(s) : Muraoka S , Miura T |
| Ref : Pharmacol Toxicol , 92 :100 , 2003 |
| Abstract : |
| PubMedSearch : Muraoka_2003_Pharmacol.Toxicol_92_100 |
| PubMedID: 12747580 |
| Title : Inhibition of butyrylcholinesterase by phenothiazine derivatives - Debord_2002_J.Enzyme.Inhib.Med.Chem_17_197 |
| Author(s) : Debord J , Merle L , Bollinger JC , Dantoine T |
| Ref : J Enzyme Inhib Med Chem , 17 :197 , 2002 |
| Abstract : |
| PubMedSearch : Debord_2002_J.Enzyme.Inhib.Med.Chem_17_197 |
| PubMedID: 12443046 |
| Title : Influence of dietary protein on the effect of coumaphos and triflupromazine interaction in sheep - Gopal_1976_Am.J.Vet.Res_37_1143 |
| Author(s) : Gopal T , Oehme FW , Omer S |
| Ref : American Journal of Veterinary Research , 37 :1143 , 1976 |
| Abstract : |
| PubMedSearch : Gopal_1976_Am.J.Vet.Res_37_1143 |
| PubMedID: 984539 |
| Title : Central and peripheral actions of anticholinergic drugs when administered with triflupromazine - |
| Author(s) : Brimblecombe RW , Green DM , Aldous FA , Thompson PB |
| Ref : Neuropharmacology , 10 :93 , 1971 |
| PubMedID: 5569310 |