VG
Amiton, was described in a 1955 paper by R Ghosh and J. F. Newman, as being particularly effective against mites It was brought to market as an insecticide by the company in 1954 but was subsequently withdrawn as too toxic. called phospholine in Clinton & Dettbarn but it is not echotiophate. produces a myopathy
General
Type : Chemical Warfare Agent, Organophosphate, Nerve Agent V-series, Sulfur Compound
Chemical_Nomenclature : 2-diethoxyphosphorylsulfanyl-N,N-diethylethanamine
Canonical SMILES : CCN(CC)CCSP(=O)(OCC)OCC
InChI : InChI=1S\/C10H24NO3PS\/c1-5-11(6-2)9-10-16-15(12,13-7-3)14-8-4\/h5-10H2,1-4H3
InChIKey : PJISLFCKHOHLLP-UHFFFAOYSA-N
Other name(s) : Metramac || AMITON || Inferno || Metram || Tetram || Amiton [BSI] || DSDP || EA-1508 || Chipman 6200 || Caswell No. 333D || Rhodia-6200 || Diethyl S-2-diethylaminoethyl phosphorothioate
MW : 269.34
Formula : C10H24NO3PS
CAS_number : 78-53-5
PubChem : 6542
UniChem : PJISLFCKHOHLLP-UHFFFAOYSA-N
References (7)
| Title : The prediction of acute toxicity (LD(50)) for organophosphorus-based chemical warfare agents (V-series) using toxicology in silico methods - Noga_2023_Arch.Toxicol_98_267 |
| Author(s) : Noga M , Michalska A , Jurowski K |
| Ref : Archives of Toxicology , 98 :267 , 2023 |
| Abstract : |
| PubMedSearch : Noga_2023_Arch.Toxicol_98_267 |
| PubMedID: 38051368 |
| Title : Determination of the structural features of O-alkyl-S-2-(N,N-dialkylamino) ethyl alkylthiophosphonates from their electron ionization mass spectra - Terentyev_2016_J.Anal.Chem_71_1266 |
| Author(s) : Terentyev AG , Morozik YI , Rybal'chenko IV , Dudkin AV , Smirnov AO , Galyaev GV |
| Ref : Journal of Analytical Chemistry , 71 :1266 , 2016 |
| Abstract : |
| PubMedSearch : Terentyev_2016_J.Anal.Chem_71_1266 |
| PubMedID: |
| Title : Gas chromatographic-mass spectrometric characterisation of amiton and the recovery of amiton from concrete, paint, rubber and soil matrices - Borrett_2003_J.Chromatogr.A_1003_143 |
| Author(s) : Borrett VT , Gan TH , Lakeland BR , Leslie DR , Mathews RJ , Mattsson ER , Riddell S , Tantaro V |
| Ref : Journal of Chromatography A , 1003 :143 , 2003 |
| Abstract : |
| PubMedSearch : Borrett_2003_J.Chromatogr.A_1003_143 |
| PubMedID: 12899304 |
| Title : Prevention of phospholine-induced myopathy with d-tubocurarine, atropine sulfate, diazepam, and creatine phosphate - Clinton_1987_J.Toxicol.Environ.Health_21_435 |
| Author(s) : Clinton ME , Dettbarn WD |
| Ref : J Toxicol Environ Health , 21 :435 , 1987 |
| Abstract : |
| PubMedSearch : Clinton_1987_J.Toxicol.Environ.Health_21_435 |
| PubMedID: 3599088 |
| Title : In vivo modulation of the number of muscarinic receptors in rat brain by cholinergic ligands - Ben-Barak_1981_Eur.J.Pharmacol_74_73 |
| Author(s) : Ben-Barak J , Gazit H , Silman I , Dudai Y |
| Ref : European Journal of Pharmacology , 74 :73 , 1981 |
| Abstract : |
| PubMedSearch : Ben-Barak_1981_Eur.J.Pharmacol_74_73 |
| PubMedID: 7318895 |
| Title : Trialkyl phosphate and phosphorothiolate anti-cholinesterases. 1. Amiton analogs - |
| Author(s) : Bracha P , O'Brien RD |
| Ref : Biochemistry , 7 :1545 , 1968 |
| PubMedID: 5677842 |