XEN445
IC50 0.237 muM human-LIPG
General
Chemical_Nomenclature : 2-[(3S)-3-(pyridin-2-ylmethoxy)pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acid
Canonical SMILES : C1CN(CC1OCC2=CC=CC=N2)C3=C(C=C(C=C3)C(F)(F)F)C(=O)O
InChI : InChI=1S\/C18H17F3N2O3\/c19-18(20,21)12-4-5-16(15(9-12)17(24)25)23-8-6-14(10-23)26-11-13-3-1-2-7-22-13\/h1-5,7,9,14H,6,8,10-11H2,(H,24,25)\/t14-\/m0\/s1
InChIKey : NBGRERFNOKZQLO-AWEZNQCLSA-N
Other name(s) : XEN-445 || XEN 445 || CHEMBL3093392 || ZINC103252336
MW : 366.3
Formula : C18H17F3N2O3
CAS_number : 1515856-92-4
PubChem : 72736173
UniChem : NBGRERFNOKZQLO-AWEZNQCLSA-N
Target
Families : XEN445 ligand of proteins in family
Lipoprotein_Lipase
Protein :
human-LIPG
References (1)
| Title : Discovery of XEN445: A potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice - Sun_2013_Bioorg.Med.Chem_21_7724 |
| Author(s) : Sun S , Dean R , Jia Q , Zenova A , Zhong J , Grayson C , Xie C , Lindgren A , Samra P , Sojo L , van Heek M , Lin L , Percival D , Fu JM , Winther MD , Zhang Z |
| Ref : Bioorganic & Medicinal Chemistry , 21 :7724 , 2013 |
| Abstract : |
| PubMedSearch : Sun_2013_Bioorg.Med.Chem_21_7724 |
| PubMedID: 24211162 |
| Gene_locus related to this paper: human-LIPG |